Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients
Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycaemia and dyslipidaemia, which places diabetics at increased risk of cardiovascular disease. We strongly believed that LDL cholesterol (LDLC), triglycerides (TG) and apolipoprotein E (apo E) genotype are closely related in...
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| Format: | Monograph |
| Language: | English |
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Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2001
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| Online Access: | http://eprints.usm.my/44985/ http://eprints.usm.my/44985/1/GP...Characterisation%20Of%20Low%20Density%20Lipoprotien%20Subfraction%20Profile%20And%20APOE%20Genotype%20Among%20Diabetic%20Patiens...2003...-OCR.pdf |
| _version_ | 1848880205936984064 |
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| author | Bebakar, Wan Mohamad Wan |
| author_facet | Bebakar, Wan Mohamad Wan |
| author_sort | Bebakar, Wan Mohamad Wan |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycaemia and dyslipidaemia, which
places diabetics at increased risk of cardiovascular disease. We strongly believed that LDL cholesterol (LDLC),
triglycerides (TG) and apolipoprotein E (apo E) genotype are closely related in determining this high risk. This
study aims to study the effect of LDL subfraction and apo E genotype on diabetic dyslipidaemia. Normal
(n=30) and diabetes mellitus type 2 (n=35) subjects who were not on any drug treatment were studied. Lipid
biochemical analysis was performed by automated methods using commercial kits. LDL size was determined
by transmission electron microscopy. LDLI and LDL2 are large panicles while LDL3, LDL4, and LDL5 are
smaller particles and are considered detrimental to health. Apo E genotype was determined by polymerase
chain reaction and restric tion fragment length polymorphism. |
| first_indexed | 2025-11-15T17:59:26Z |
| format | Monograph |
| id | usm-44985 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:59:26Z |
| publishDate | 2001 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-449852020-03-13T01:00:44Z http://eprints.usm.my/44985/ Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients Bebakar, Wan Mohamad Wan RC Internal medicine Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycaemia and dyslipidaemia, which places diabetics at increased risk of cardiovascular disease. We strongly believed that LDL cholesterol (LDLC), triglycerides (TG) and apolipoprotein E (apo E) genotype are closely related in determining this high risk. This study aims to study the effect of LDL subfraction and apo E genotype on diabetic dyslipidaemia. Normal (n=30) and diabetes mellitus type 2 (n=35) subjects who were not on any drug treatment were studied. Lipid biochemical analysis was performed by automated methods using commercial kits. LDL size was determined by transmission electron microscopy. LDLI and LDL2 are large panicles while LDL3, LDL4, and LDL5 are smaller particles and are considered detrimental to health. Apo E genotype was determined by polymerase chain reaction and restric tion fragment length polymorphism. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2001 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/44985/1/GP...Characterisation%20Of%20Low%20Density%20Lipoprotien%20Subfraction%20Profile%20And%20APOE%20Genotype%20Among%20Diabetic%20Patiens...2003...-OCR.pdf Bebakar, Wan Mohamad Wan (2001) Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients. UNSPECIFIED. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia. (Submitted) |
| spellingShingle | RC Internal medicine Bebakar, Wan Mohamad Wan Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients |
| title | Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients |
| title_full | Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients |
| title_fullStr | Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients |
| title_full_unstemmed | Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients |
| title_short | Characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients |
| title_sort | characterisation of low density lipoprotein subfraction profile and apoe genotype among diabetic patients |
| topic | RC Internal medicine |
| url | http://eprints.usm.my/44985/ http://eprints.usm.my/44985/1/GP...Characterisation%20Of%20Low%20Density%20Lipoprotien%20Subfraction%20Profile%20And%20APOE%20Genotype%20Among%20Diabetic%20Patiens...2003...-OCR.pdf |