The mRNA Expression Of Inducible Nitric Oxide Synthase In Keloid Using Tocotrienol-Rich Fraction In Primary Human Epidermal Keratinocytes And Primary Human Dermal Fibroblast Cultures
Keloid is characterized by excess collagen deposition that can damage healthy tissue. With the widespread use of Vitamin E- tocopherols based product and the discovery of tocotrienol (T3) potential to treat various skin injuries; there are possibilities of tocotrienol-rich fraction (TRF) to interced...
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| Format: | Thesis |
| Language: | English |
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2012
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| Online Access: | http://eprints.usm.my/44896/ http://eprints.usm.my/44896/1/SITI%20MAHIRAH%20BINTI%20YUSUF.pdf |
| _version_ | 1848880183952539648 |
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| author | Yusuf, Siti Mahirah |
| author_facet | Yusuf, Siti Mahirah |
| author_sort | Yusuf, Siti Mahirah |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Keloid is characterized by excess collagen deposition that can damage healthy tissue. With the widespread use of Vitamin E- tocopherols based product and the discovery of tocotrienol (T3) potential to treat various skin injuries; there are possibilities of tocotrienol-rich fraction (TRF) to intercede normal, hypertrophic, or keloid scarring during the inflammatory process. However, there is a lack of scientific evidence to validate the efficacy and the therapies of TRF in scar prevention. Thus, this study was carried out to evaluate the beneficial effects of TRF in wound healing and its possible stimulation towards mRNA expression of inducible nitric oxide synthase (iNOS) in keloid human skin keratinocytes and fibroblasts. |
| first_indexed | 2025-11-15T17:59:05Z |
| format | Thesis |
| id | usm-44896 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:59:05Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-448962019-07-05T08:20:53Z http://eprints.usm.my/44896/ The mRNA Expression Of Inducible Nitric Oxide Synthase In Keloid Using Tocotrienol-Rich Fraction In Primary Human Epidermal Keratinocytes And Primary Human Dermal Fibroblast Cultures Yusuf, Siti Mahirah R5-920 Medicine (General) Keloid is characterized by excess collagen deposition that can damage healthy tissue. With the widespread use of Vitamin E- tocopherols based product and the discovery of tocotrienol (T3) potential to treat various skin injuries; there are possibilities of tocotrienol-rich fraction (TRF) to intercede normal, hypertrophic, or keloid scarring during the inflammatory process. However, there is a lack of scientific evidence to validate the efficacy and the therapies of TRF in scar prevention. Thus, this study was carried out to evaluate the beneficial effects of TRF in wound healing and its possible stimulation towards mRNA expression of inducible nitric oxide synthase (iNOS) in keloid human skin keratinocytes and fibroblasts. 2012 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44896/1/SITI%20MAHIRAH%20BINTI%20YUSUF.pdf Yusuf, Siti Mahirah (2012) The mRNA Expression Of Inducible Nitric Oxide Synthase In Keloid Using Tocotrienol-Rich Fraction In Primary Human Epidermal Keratinocytes And Primary Human Dermal Fibroblast Cultures. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Yusuf, Siti Mahirah The mRNA Expression Of Inducible Nitric Oxide Synthase In Keloid Using Tocotrienol-Rich Fraction In Primary Human Epidermal Keratinocytes And Primary Human Dermal Fibroblast Cultures |
| title | The mRNA Expression Of Inducible Nitric Oxide Synthase In Keloid Using Tocotrienol-Rich Fraction In Primary Human Epidermal Keratinocytes And Primary Human Dermal Fibroblast Cultures |
| title_full | The mRNA Expression Of Inducible Nitric Oxide Synthase In Keloid Using Tocotrienol-Rich Fraction In Primary Human Epidermal Keratinocytes And Primary Human Dermal Fibroblast Cultures |
| title_fullStr | The mRNA Expression Of Inducible Nitric Oxide Synthase In Keloid Using Tocotrienol-Rich Fraction In Primary Human Epidermal Keratinocytes And Primary Human Dermal Fibroblast Cultures |
| title_full_unstemmed | The mRNA Expression Of Inducible Nitric Oxide Synthase In Keloid Using Tocotrienol-Rich Fraction In Primary Human Epidermal Keratinocytes And Primary Human Dermal Fibroblast Cultures |
| title_short | The mRNA Expression Of Inducible Nitric Oxide Synthase In Keloid Using Tocotrienol-Rich Fraction In Primary Human Epidermal Keratinocytes And Primary Human Dermal Fibroblast Cultures |
| title_sort | mrna expression of inducible nitric oxide synthase in keloid using tocotrienol-rich fraction in primary human epidermal keratinocytes and primary human dermal fibroblast cultures |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/44896/ http://eprints.usm.my/44896/1/SITI%20MAHIRAH%20BINTI%20YUSUF.pdf |