Clozapine-Induced Myocarditis and Pericarditis
Objective: Clozapine is known to cause cardiac side-effects, including myocarditis, pericarditis and cardiomyopathy. A 50-year-old Malay man with schizoaffective disorder and tardive dyskinesia who developed transient tachycardia, low blood pressure and fever after 17 days of starting clozapine wa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Japan International Cultural Exchange Foundation
2014
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| Subjects: | |
| Online Access: | http://eprints.usm.my/44712/ http://eprints.usm.my/44712/1/Clozapine-Induced%20Myocarditis%20and%20Pericarditis%20%282014%29.pdf |
| _version_ | 1848880133865209856 |
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| author | Othman, Zahiruddin Ahmad, Fazil Halim, Ahmad Shahril Abdul Ismail, Nurul Nadia |
| author_facet | Othman, Zahiruddin Ahmad, Fazil Halim, Ahmad Shahril Abdul Ismail, Nurul Nadia |
| author_sort | Othman, Zahiruddin |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Objective: Clozapine is known to cause cardiac side-effects, including myocarditis, pericarditis and cardiomyopathy. A
50-year-old Malay man with schizoaffective disorder and tardive dyskinesia who developed transient tachycardia, low blood
pressure and fever after 17 days of starting clozapine was studied.
Result: Elevated creatinine kinase at 532 U/l along with WBC and neutrophil count at 21.40 and 16.83 x 1071 respectively
indicated an acute myocarditis. Additionally, pericardium involvement was suggested by V1-V4 ST elevation and absence of T
wave inversion.
Conclusion: The emergence of tachycardia, low blood pressure and fever in patient who is recently started on clozapine
treatment should be investigated for cardiac complications. Old age and concomitant treatment with sodium valproate possibly
increased the risk of clozapine-induced cardiac side-effects |
| first_indexed | 2025-11-15T17:58:17Z |
| format | Article |
| id | usm-44712 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:58:17Z |
| publishDate | 2014 |
| publisher | Japan International Cultural Exchange Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-447122019-06-23T04:41:01Z http://eprints.usm.my/44712/ Clozapine-Induced Myocarditis and Pericarditis Othman, Zahiruddin Ahmad, Fazil Halim, Ahmad Shahril Abdul Ismail, Nurul Nadia RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Objective: Clozapine is known to cause cardiac side-effects, including myocarditis, pericarditis and cardiomyopathy. A 50-year-old Malay man with schizoaffective disorder and tardive dyskinesia who developed transient tachycardia, low blood pressure and fever after 17 days of starting clozapine was studied. Result: Elevated creatinine kinase at 532 U/l along with WBC and neutrophil count at 21.40 and 16.83 x 1071 respectively indicated an acute myocarditis. Additionally, pericardium involvement was suggested by V1-V4 ST elevation and absence of T wave inversion. Conclusion: The emergence of tachycardia, low blood pressure and fever in patient who is recently started on clozapine treatment should be investigated for cardiac complications. Old age and concomitant treatment with sodium valproate possibly increased the risk of clozapine-induced cardiac side-effects Japan International Cultural Exchange Foundation 2014-12 Article PeerReviewed application/pdf en http://eprints.usm.my/44712/1/Clozapine-Induced%20Myocarditis%20and%20Pericarditis%20%282014%29.pdf Othman, Zahiruddin and Ahmad, Fazil and Halim, Ahmad Shahril Abdul and Ismail, Nurul Nadia (2014) Clozapine-Induced Myocarditis and Pericarditis. International Medical Journal, 21 (6). pp. 539-540. ISSN 1341-2051 http://www.seronjihou.co.jp/IMJ/backnumber-IMJ.html |
| spellingShingle | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Othman, Zahiruddin Ahmad, Fazil Halim, Ahmad Shahril Abdul Ismail, Nurul Nadia Clozapine-Induced Myocarditis and Pericarditis |
| title | Clozapine-Induced Myocarditis and Pericarditis |
| title_full | Clozapine-Induced Myocarditis and Pericarditis |
| title_fullStr | Clozapine-Induced Myocarditis and Pericarditis |
| title_full_unstemmed | Clozapine-Induced Myocarditis and Pericarditis |
| title_short | Clozapine-Induced Myocarditis and Pericarditis |
| title_sort | clozapine-induced myocarditis and pericarditis |
| topic | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| url | http://eprints.usm.my/44712/ http://eprints.usm.my/44712/ http://eprints.usm.my/44712/1/Clozapine-Induced%20Myocarditis%20and%20Pericarditis%20%282014%29.pdf |