Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women
his study aimed to investigate the ability of Tualang honey (TH), a phytoestrogen, to reduce blood oxidative stress levels/activities in postmenopausal women and compared the efects with the standard estrogen progestin therapy (EPT). A total of 78 healthy postmenopausal women were randomly assigne...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2014
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| Subjects: | |
| Online Access: | http://eprints.usm.my/44530/ http://eprints.usm.my/44530/1/2014_ISRN_Oxidative_Medicine_-_TH_suppl-libre.pdf |
| Summary: | his study aimed to investigate the ability of Tualang honey (TH), a phytoestrogen, to reduce blood oxidative stress levels/activities
in postmenopausal women and compared the efects with the standard estrogen progestin therapy (EPT). A total of 78 healthy
postmenopausal women were randomly assigned to one of two groups; EPT group received Femoston conti 1/5 (1mg 17�-
estradiol and 5mg dydrogesterone), and TH group, received 20 g of TH supplement daily for 16 weeks. he reduced glutathione to
oxidized glutathione ratio (GSH:GSSG), plasma glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and
�-hydroxynonenal (�-HNE) levels/activities were measured at pre- and postinterventions using commercially available kits. he
plasma GPx and CAT activities were notably increased, and plasma �-HNE level was signiicantly decreased in postmenopausal
women who received EPT and TH supplementation. TH supplementation for 16 weeks was able to reduce blood oxidative stress
levels/activities of postmenopausal women comparable to those who received EPT. hus, TH has a potential to be used as
antioxidant therapy to combat oxidative stress-induced neurodegenerative diseases.his trial is registered with NCT01300676. |
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