Association of oxidative stress and memory performance in postmenopausal women receiving estrogen-progestin therapy
Objective: The aim of this study was to examine the association between changes in blood oxidative stress level/ activity and changes in memory performance among postmenopausal women. Methods: This study involved 39 postmenopausal women who received estrogen-progestin therapy (EPT) for 16 weeks....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The North American Menopause Society
2013
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| Subjects: | |
| Online Access: | http://eprints.usm.my/44480/ http://eprints.usm.my/44480/1/10.1097%40gme.0b013e31827758c6.pdf |
| _version_ | 1848880071259979776 |
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| author | Shafin, Nazlahshaniza Zakaria, Rahimah Hussain, Nik Hazlina Nik Othman, Zahiruddin |
| author_facet | Shafin, Nazlahshaniza Zakaria, Rahimah Hussain, Nik Hazlina Nik Othman, Zahiruddin |
| author_sort | Shafin, Nazlahshaniza |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Objective: The aim of this study was to examine the association between changes in blood oxidative stress level/
activity and changes in memory performance among postmenopausal women.
Methods: This study involved 39 postmenopausal women who received estrogen-progestin therapy (EPT) for
16 weeks. Verbal learning and memory performance were assessed using the Malay Version of Auditory Verbal
Learning Test before and after 16 weeks of EPT. Oxidative stress levels/activities before and after 16 weeks of EPT
were determined using commercially available kits. Data were analyzed using paired t test and r. P G 0.05 was
considered significant.
Results: The activities of glutathione peroxidase and catalase were considerably increased (P G 0.05), but the
level of 4-hydroxynonenal was notably decreased (P G 0.05), after 16 weeks of EPT. There were positive correlations
between changes in plasma superoxide dismutase and changes in trial A2 scores (r = 0.36, P G 0.05), and
between changes in the ratio of blood reduced glutathione to oxidized glutathione and changes in trial A2 scores (r =
0.34, P G 0.05).
Conclusions: Sixteen weeks of EPT increase blood antioxidant capacity. However, most of the changes in
oxidative stress level/activity are not significantly associated with changes in the memory performance of postmenopausal
women. |
| first_indexed | 2025-11-15T17:57:18Z |
| format | Article |
| id | usm-44480 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:57:18Z |
| publishDate | 2013 |
| publisher | The North American Menopause Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-444802019-05-31T02:04:52Z http://eprints.usm.my/44480/ Association of oxidative stress and memory performance in postmenopausal women receiving estrogen-progestin therapy Shafin, Nazlahshaniza Zakaria, Rahimah Hussain, Nik Hazlina Nik Othman, Zahiruddin RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Objective: The aim of this study was to examine the association between changes in blood oxidative stress level/ activity and changes in memory performance among postmenopausal women. Methods: This study involved 39 postmenopausal women who received estrogen-progestin therapy (EPT) for 16 weeks. Verbal learning and memory performance were assessed using the Malay Version of Auditory Verbal Learning Test before and after 16 weeks of EPT. Oxidative stress levels/activities before and after 16 weeks of EPT were determined using commercially available kits. Data were analyzed using paired t test and r. P G 0.05 was considered significant. Results: The activities of glutathione peroxidase and catalase were considerably increased (P G 0.05), but the level of 4-hydroxynonenal was notably decreased (P G 0.05), after 16 weeks of EPT. There were positive correlations between changes in plasma superoxide dismutase and changes in trial A2 scores (r = 0.36, P G 0.05), and between changes in the ratio of blood reduced glutathione to oxidized glutathione and changes in trial A2 scores (r = 0.34, P G 0.05). Conclusions: Sixteen weeks of EPT increase blood antioxidant capacity. However, most of the changes in oxidative stress level/activity are not significantly associated with changes in the memory performance of postmenopausal women. The North American Menopause Society 2013 Article PeerReviewed application/pdf en http://eprints.usm.my/44480/1/10.1097%40gme.0b013e31827758c6.pdf Shafin, Nazlahshaniza and Zakaria, Rahimah and Hussain, Nik Hazlina Nik and Othman, Zahiruddin (2013) Association of oxidative stress and memory performance in postmenopausal women receiving estrogen-progestin therapy. Menopause: The Journal of The North American Menopause Society, 20 (6). pp. 661-666. ISSN 1072-3714 https://journals.lww.com/menopausejournal/Abstract/2013/06000/Association_of_oxidative_stress_and_memory.12.aspx |
| spellingShingle | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Shafin, Nazlahshaniza Zakaria, Rahimah Hussain, Nik Hazlina Nik Othman, Zahiruddin Association of oxidative stress and memory performance in postmenopausal women receiving estrogen-progestin therapy |
| title | Association of oxidative stress and memory performance in
postmenopausal women receiving estrogen-progestin therapy |
| title_full | Association of oxidative stress and memory performance in
postmenopausal women receiving estrogen-progestin therapy |
| title_fullStr | Association of oxidative stress and memory performance in
postmenopausal women receiving estrogen-progestin therapy |
| title_full_unstemmed | Association of oxidative stress and memory performance in
postmenopausal women receiving estrogen-progestin therapy |
| title_short | Association of oxidative stress and memory performance in
postmenopausal women receiving estrogen-progestin therapy |
| title_sort | association of oxidative stress and memory performance in
postmenopausal women receiving estrogen-progestin therapy |
| topic | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| url | http://eprints.usm.my/44480/ http://eprints.usm.my/44480/ http://eprints.usm.my/44480/1/10.1097%40gme.0b013e31827758c6.pdf |