Insight into potential mechanisms of hypobaric hypoxia–induced learning and memory deficit – Lessons from rat studies
Impairment of memory is one of the most frequently reported symptoms during sudden hypoxia exposure in human. Cortical atrophy has been linked to the impaired memory function and is suggested to occur with chronic high-altitude exposure. However, the precise molecular mechanism(s) of hypoxia-induc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2017
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| Online Access: | http://eprints.usm.my/44405/ http://eprints.usm.my/44405/1/Insight%20into%20potential%20mechanisms%20of%20hypobaric%20hypoxia%E2%80%93induced%20learning%20and%20memory%20deficit.pdf |
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| author | Qaid, EYA Zakaria, R Sulaiman, SF Yusof, NA Mohd Shafin, Nazlahshaniza Othman, Zahiruddin Ahmad, AH Aziz, CB Abd |
| author_facet | Qaid, EYA Zakaria, R Sulaiman, SF Yusof, NA Mohd Shafin, Nazlahshaniza Othman, Zahiruddin Ahmad, AH Aziz, CB Abd |
| author_sort | Qaid, EYA |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Impairment of memory is one of the most frequently reported symptoms during sudden hypoxia exposure in
human. Cortical atrophy has been linked to the impaired memory function and is suggested to occur with
chronic high-altitude exposure. However, the precise molecular mechanism(s) of hypoxia-induced memory
impairment remains an enigma. In this work, we review hypoxia-induced learning and memory deficit in human
and rat studies. Based on data from rat studies using different protocols of continuous hypoxia, we try to elicit
potential mechanisms of hypobaric hypoxia–induced memory deficit. |
| first_indexed | 2025-11-15T17:56:57Z |
| format | Article |
| id | usm-44405 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:56:57Z |
| publishDate | 2017 |
| publisher | SAGE Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-444052019-05-28T09:09:59Z http://eprints.usm.my/44405/ Insight into potential mechanisms of hypobaric hypoxia–induced learning and memory deficit – Lessons from rat studies Qaid, EYA Zakaria, R Sulaiman, SF Yusof, NA Mohd Shafin, Nazlahshaniza Othman, Zahiruddin Ahmad, AH Aziz, CB Abd RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Impairment of memory is one of the most frequently reported symptoms during sudden hypoxia exposure in human. Cortical atrophy has been linked to the impaired memory function and is suggested to occur with chronic high-altitude exposure. However, the precise molecular mechanism(s) of hypoxia-induced memory impairment remains an enigma. In this work, we review hypoxia-induced learning and memory deficit in human and rat studies. Based on data from rat studies using different protocols of continuous hypoxia, we try to elicit potential mechanisms of hypobaric hypoxia–induced memory deficit. SAGE Publications 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/44405/1/Insight%20into%20potential%20mechanisms%20of%20hypobaric%20hypoxia%E2%80%93induced%20learning%20and%20memory%20deficit.pdf Qaid, EYA and Zakaria, R and Sulaiman, SF and Yusof, NA Mohd and Shafin, Nazlahshaniza and Othman, Zahiruddin and Ahmad, AH and Aziz, CB Abd (2017) Insight into potential mechanisms of hypobaric hypoxia–induced learning and memory deficit – Lessons from rat studies. Human and Experimental Toxicology, 36 (12). pp. 1-11. ISSN 0960-3271 (Submitted) https://journals.sagepub.com/doi/10.1177/0960327116689714 |
| spellingShingle | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Qaid, EYA Zakaria, R Sulaiman, SF Yusof, NA Mohd Shafin, Nazlahshaniza Othman, Zahiruddin Ahmad, AH Aziz, CB Abd Insight into potential mechanisms of hypobaric hypoxia–induced learning and memory deficit – Lessons from rat studies |
| title | Insight into potential mechanisms of
hypobaric hypoxia–induced learning
and memory deficit – Lessons from
rat studies |
| title_full | Insight into potential mechanisms of
hypobaric hypoxia–induced learning
and memory deficit – Lessons from
rat studies |
| title_fullStr | Insight into potential mechanisms of
hypobaric hypoxia–induced learning
and memory deficit – Lessons from
rat studies |
| title_full_unstemmed | Insight into potential mechanisms of
hypobaric hypoxia–induced learning
and memory deficit – Lessons from
rat studies |
| title_short | Insight into potential mechanisms of
hypobaric hypoxia–induced learning
and memory deficit – Lessons from
rat studies |
| title_sort | insight into potential mechanisms of
hypobaric hypoxia–induced learning
and memory deficit – lessons from
rat studies |
| topic | RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| url | http://eprints.usm.my/44405/ http://eprints.usm.my/44405/ http://eprints.usm.my/44405/1/Insight%20into%20potential%20mechanisms%20of%20hypobaric%20hypoxia%E2%80%93induced%20learning%20and%20memory%20deficit.pdf |