Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats
Mitragyna speciosa (M. speciosa) Korth is a traditional herbal plant indigenous to Southeast Asia. Regular use of this plant by human may lead to addiction with profound withdrawal symptoms. It is hypothesized that the abuse of M. speciosa preparations could be attributed to mitragynine, the main ps...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | http://eprints.usm.my/44127/ http://eprints.usm.my/44127/1/NURUL%20HASNIDA%20MOHAMMAD%20YUSOFF.pdf |
| _version_ | 1848879981727318016 |
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| author | Yusoff, Nurul Hasnida Mohammad |
| author_facet | Yusoff, Nurul Hasnida Mohammad |
| author_sort | Yusoff, Nurul Hasnida Mohammad |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Mitragyna speciosa (M. speciosa) Korth is a traditional herbal plant indigenous to Southeast Asia. Regular use of this plant by human may lead to addiction with profound withdrawal symptoms. It is hypothesized that the abuse of M. speciosa preparations could be attributed to mitragynine, the main psychoactive compound isolated from its leaves. Therefore, comprehensive studies on the rewarding properties of mitragynine, as well as the mechanisms invoved, are needed. In the first part of the study, the rewarding properties of mitragynine (1, 5, 10 and 30 mg/kg) and its locomotor effects were investigated in Sprague-Dawley rats, using a conditioned place preference (CPP) paradigm. |
| first_indexed | 2025-11-15T17:55:52Z |
| format | Thesis |
| id | usm-44127 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:55:52Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-441272019-04-18T02:47:15Z http://eprints.usm.my/44127/ Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats Yusoff, Nurul Hasnida Mohammad RS1-441 Pharmacy and materia medica Mitragyna speciosa (M. speciosa) Korth is a traditional herbal plant indigenous to Southeast Asia. Regular use of this plant by human may lead to addiction with profound withdrawal symptoms. It is hypothesized that the abuse of M. speciosa preparations could be attributed to mitragynine, the main psychoactive compound isolated from its leaves. Therefore, comprehensive studies on the rewarding properties of mitragynine, as well as the mechanisms invoved, are needed. In the first part of the study, the rewarding properties of mitragynine (1, 5, 10 and 30 mg/kg) and its locomotor effects were investigated in Sprague-Dawley rats, using a conditioned place preference (CPP) paradigm. 2018-05 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44127/1/NURUL%20HASNIDA%20MOHAMMAD%20YUSOFF.pdf Yusoff, Nurul Hasnida Mohammad (2018) Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Yusoff, Nurul Hasnida Mohammad Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title | Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_full | Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_fullStr | Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_full_unstemmed | Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_short | Mitragynine-Induced Conditioned Place Preference (CPP) And The Profiles Of Dopamine And Its Metabolites In Rats |
| title_sort | mitragynine-induced conditioned place preference (cpp) and the profiles of dopamine and its metabolites in rats |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/44127/ http://eprints.usm.my/44127/1/NURUL%20HASNIDA%20MOHAMMAD%20YUSOFF.pdf |