Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models
β-carboline is known for its numerous traditional uses and has been widely investigated for various health indications. In particular, recently β-carboline has shown some promising findings in the field of anticancer. Hence this study investigates the potential anticancer activity of β-carboline com...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | http://eprints.usm.my/44126/ http://eprints.usm.my/44126/1/NUR%20AZZALIA%20KAMARUZAMAN.pdf |
| _version_ | 1848879981479854080 |
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| author | Kamaruzaman, Nur Azzalia |
| author_facet | Kamaruzaman, Nur Azzalia |
| author_sort | Kamaruzaman, Nur Azzalia |
| building | USM Institutional Repository |
| collection | Online Access |
| description | β-carboline is known for its numerous traditional uses and has been widely investigated for various health indications. In particular, recently β-carboline has shown some promising findings in the field of anticancer. Hence this study investigates the potential anticancer activity of β-carboline compounds using in vitro models. Thirty synthesized β-carboline compounds were tested using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for anticancer activity and selectivity index (SI) against four human cancer (colon HT-29, cervical HeLa, liver Hep G2 and leukemia K562) and two non-cancer (mouse embryo fibroblasts BALB/c3T3 and human foreskin fibroblasts Hs27) cell lines. |
| first_indexed | 2025-11-15T17:55:52Z |
| format | Thesis |
| id | usm-44126 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:55:52Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-441262019-04-18T02:42:55Z http://eprints.usm.my/44126/ Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models Kamaruzaman, Nur Azzalia RS1-441 Pharmacy and materia medica β-carboline is known for its numerous traditional uses and has been widely investigated for various health indications. In particular, recently β-carboline has shown some promising findings in the field of anticancer. Hence this study investigates the potential anticancer activity of β-carboline compounds using in vitro models. Thirty synthesized β-carboline compounds were tested using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for anticancer activity and selectivity index (SI) against four human cancer (colon HT-29, cervical HeLa, liver Hep G2 and leukemia K562) and two non-cancer (mouse embryo fibroblasts BALB/c3T3 and human foreskin fibroblasts Hs27) cell lines. 2018-04 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44126/1/NUR%20AZZALIA%20KAMARUZAMAN.pdf Kamaruzaman, Nur Azzalia (2018) Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Kamaruzaman, Nur Azzalia Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models |
| title | Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models |
| title_full | Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models |
| title_fullStr | Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models |
| title_full_unstemmed | Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models |
| title_short | Apoptosis And Genotoxicity Of Selected Β-Carboline Compounds Against Chronic Myelogenous Leukemia Using In Vitro Experimental Models |
| title_sort | apoptosis and genotoxicity of selected β-carboline compounds against chronic myelogenous leukemia using in vitro experimental models |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/44126/ http://eprints.usm.my/44126/1/NUR%20AZZALIA%20KAMARUZAMAN.pdf |