Keloid Scarring: Understanding the Genetic Basis, Advances, and Prospects
Keloid disease is a fibroproliferative dermal tumor with an unknown etiology that occurs after a skin injury in genetically susceptible individuals. Increased familial aggregation, a higher prevalence in certain races, parallelism in identical twins, and alteration in gene expression all favor a...
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| Format: | Article |
| Language: | English |
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Korean Society of Plastic and Reconstructive Surgeons
2012
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| Online Access: | http://eprints.usm.my/43871/ http://eprints.usm.my/43871/1/aps-39-184.pdf |
| _version_ | 1848879917276594176 |
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| author | Halim, Ahmad Sukari Emami, Azadeh Salahshourifar, Iman Kannan, Thirumulu Ponnuraj |
| author_facet | Halim, Ahmad Sukari Emami, Azadeh Salahshourifar, Iman Kannan, Thirumulu Ponnuraj |
| author_sort | Halim, Ahmad Sukari |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Keloid disease is a fibroproliferative dermal tumor with an unknown etiology that occurs after
a skin injury in genetically susceptible individuals. Increased familial aggregation, a higher
prevalence in certain races, parallelism in identical twins, and alteration in gene expression all
favor a remarkable genetic contribution to keloid pathology. It seems that the environment
triggers the disease in genetically susceptible individuals. Several genes have been implicated
in the etiology of keloid disease, but no single gene mutation has thus far been found to be
responsible. Therefore, a combination of methods such as association, gene-gene interaction,
epigenetics, linkage, gene expression, and protein analysis should be applied to determine
keloid etiology. |
| first_indexed | 2025-11-15T17:54:51Z |
| format | Article |
| id | usm-43871 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:54:51Z |
| publishDate | 2012 |
| publisher | Korean Society of Plastic and Reconstructive Surgeons |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-438712019-04-01T04:58:42Z http://eprints.usm.my/43871/ Keloid Scarring: Understanding the Genetic Basis, Advances, and Prospects Halim, Ahmad Sukari Emami, Azadeh Salahshourifar, Iman Kannan, Thirumulu Ponnuraj RK1-715 Dentistry Keloid disease is a fibroproliferative dermal tumor with an unknown etiology that occurs after a skin injury in genetically susceptible individuals. Increased familial aggregation, a higher prevalence in certain races, parallelism in identical twins, and alteration in gene expression all favor a remarkable genetic contribution to keloid pathology. It seems that the environment triggers the disease in genetically susceptible individuals. Several genes have been implicated in the etiology of keloid disease, but no single gene mutation has thus far been found to be responsible. Therefore, a combination of methods such as association, gene-gene interaction, epigenetics, linkage, gene expression, and protein analysis should be applied to determine keloid etiology. Korean Society of Plastic and Reconstructive Surgeons 2012 Article PeerReviewed application/pdf en http://eprints.usm.my/43871/1/aps-39-184.pdf Halim, Ahmad Sukari and Emami, Azadeh and Salahshourifar, Iman and Kannan, Thirumulu Ponnuraj (2012) Keloid Scarring: Understanding the Genetic Basis, Advances, and Prospects. Archives of Plastic Surgery, 39 (3). pp. 184-189. ISSN 2234-6163 https://doi.org/10.5999/aps.2012.39.3.184 |
| spellingShingle | RK1-715 Dentistry Halim, Ahmad Sukari Emami, Azadeh Salahshourifar, Iman Kannan, Thirumulu Ponnuraj Keloid Scarring: Understanding the Genetic Basis, Advances, and Prospects |
| title | Keloid Scarring: Understanding the Genetic Basis,
Advances, and Prospects |
| title_full | Keloid Scarring: Understanding the Genetic Basis,
Advances, and Prospects |
| title_fullStr | Keloid Scarring: Understanding the Genetic Basis,
Advances, and Prospects |
| title_full_unstemmed | Keloid Scarring: Understanding the Genetic Basis,
Advances, and Prospects |
| title_short | Keloid Scarring: Understanding the Genetic Basis,
Advances, and Prospects |
| title_sort | keloid scarring: understanding the genetic basis,
advances, and prospects |
| topic | RK1-715 Dentistry |
| url | http://eprints.usm.my/43871/ http://eprints.usm.my/43871/ http://eprints.usm.my/43871/1/aps-39-184.pdf |