Influence of ORM1, PXR, CAR, CYP3A4 and CYP3A5 gene polymorphisms in mediating susceptibility risk to chronic myeloid leukaemia and response to imatinib mesylate therapy

QR Code

Influence of ORM1, PXR, CAR, CYP3A4 and CYP3A5 gene polymorphisms in mediating susceptibility risk to chronic myeloid leukaemia and response to imatinib mesylate therapy

Genetic polymorphisms are well recognized sources of individual differences in disease risk and treatment response. Associations between human genetic variants and predisposition to diseases and adverse events for different kinds of drug interactions with hundreds of protein like receptors, trans...

Full description

Bibliographic Details
Main Author:	Maddin, Najlaa
Format:	Thesis
Language:	English
Published:	2017
Subjects:	R Medicine (General)
Online Access:	http://eprints.usm.my/43138/ http://eprints.usm.my/43138/1/Dr._Najlaa_Maddin-24_pages.pdf

Similar Items

Genetic determinants excluding GBCR::ABL mutations of imatinib mesylate therapy response among chronic myeloid leukaemia patients in Malaysia
by: Ismail, Siti Mariam
Published: (2023)

Influence of tert gene expression, telomerase activity and telomere length in relation to imatinib mesylate resistance in Malaysian chronic myeloid leukaemia patients
by: Shamshudin, Wati @ Hayati Mohd
Published: (2020)

Determination of gene copy number status in tert and terc among chronic myeloid leukaemia patients resist ant and responsive to imatinib mesylate treatment
by: Asrari, Zaidatul Shakila Mohamad
Published: (2014)

Disease acceptance and adherence to imatinib in Taiwanese chronic myeloid leukaemia outpatients
by: Chen, Li-Chia, et al.
Published: (2014)

Detection of PDGFRA mutations at exons 12 and 18 among chronic myeloid leukemia patients treated with imatinib mesylate
by: Razali, Ruzi Hamimi
Published: (2015)

Molecular basis of primary and secondary resistance to imatinib mesylate
by: Abdul Aziz, Baba
Published: (2012)

Population Pharmacokinetics Of Repaglinide In Healthy Subjects And Genetic Polymorphisms Of Cyp3a4 And Cyp2c8
by: Abu Bakar, Ruzilawati
Published: (2008)

Genetic polymorphisms of cyp3a4 and cyp2c8 in heal thy volunteers administered with repaglinide
by: Gan Siew, Hua
Published: (2008)

A review on CYP11A1, CYP17A1, and CYP19A1 polymorphism studies: candidate susceptibility genes for polycystic ovary syndrome (PCOS) and infertility
by: Heidarzadehpilehrood, Roozbeh, et al.
Published: (2022)

Contribution of BCR-ABL kinase domain mutations to imatinib mesylate resistance in Philadelphia chromosome positive Malaysian chronic myeloid leukemia patients
by: Elias, Marjanu Hikmah, et al.
Published: (2012)

Molecular genetic and epigenetic mechanisms of primary and secondary resistance to imatinib mesylate treatment in ph chromosome positive chronic myeloid leukemia patients
by: Elias, Marjanu Hikmah
Published: (2015)

Genetic polymorphisms of CYP 3A4 & CYP2C8 in healthy volunteers title of project administered with repaglinide
by: Hua, Gan Siew
Published: (2008)

The impact of CYP3A4 and CYP3A5 polymorphisms on anastrozole's pharmacokinetics and pharmacodynamics in post-menopausal breast cancer patients
by: Abubakar, Murtala Bello
Published: (2017)

Tacrolimus pharmacogenetics: the influence of genetic polymorphisms of CYP3A5, MDRl and Pregnane X Receptor (PXR) in transplant patients / Professor Dr. Mohd Zaki Salleh and Associate Prof. Dr Teh Lay Kek
by: Salleh, Mohd Zaki, et al.
Published: (2010)

The role of pharmacogenetic variation in metoprolol CYP2D6 genotypes polymorphism
by: Wan Sulaiman, Wan Mohd. Azizi, et al.
Published: (2011)

Contribution of CYP2E1 polymorphism to aging in the mechanical workshop workers
by: Eshkoor, Sima Ataollahi, et al.
Published: (2013)

A single nucleotide polymorphism in the CYP4F2 but not CYP4A11 gene is associated with increased 20-HETE excretion and blood pressure
by: Ward, Natalie, et al.
Published: (2008)

C-kit Inhibition by Imatinib Mesylate Attenuates Progenitor Cell Expansion and Inhibits Liver Tumor Formation in Mice
by: Knight, B., et al.
Published: (2008)

CYP2C9 polymorphism: prevalence in healthy and warfarin-treated Malay and Chinese in Malaysia
by: Ngow, Harris Abdullah, et al.
Published: (2009)

Genetic Polymorphisms In The CYP2A6: Implications For Inter-Individual Differences In Nicotine Metabolism
by: Musa, Nurfadhlina
Published: (2006)

Influence Of Cyp2d6 And Drd2 Polymorphisms On Clinical Outcomes Of Patients With Schizophrenia
by: Zahari, Zalina
Published: (2009)

Detection of BCR-ABL T315i mutation in imatinib resistant chronic myeloid leukemia patients
by: Mardziah M,, et al.
Published: (2019)

ENPP4 and HOXA3 as potential leukaemia stem cell markers in acute myeloid leukaemia
by: Mohd Amin, A, et al.
Published: (2023)

The influence of genetic polymorphisms of CYP3A on the pharmacokinetic variation and clinical outcomes of tacrolimus in a cohort of patients / Mohd Rahimi Muda
by: Muda, Mohd Rahimi
Published: (2014)

A CYP26B1 polymorphism enhances retinoic acid catabolism and may aggravate atherosclerosis.
by: Krivospitskaya, O., et al.
Published: (2012)

Genetic Polymorphism of CYP2D6 and MDR1 in breast cancer patients treated with tamoxifen
by: Mohamad, NI, et al.
Published: (2010)

CYP2D6 genetic polymorphisms and phenotypes in different ethnicities of Malaysian breast cancer patients
by: Fee, Wai Chin, et al.
Published: (2016)

Targeting dormancy in acute myeloid leukaemia
by: Doolan, Lara
Published: (2023)

Molecular Basis of CYP2B2 Induction
by: Horley, Neill
Published: (1999)

Imatinab mesylate treatment in Chronic Myeloid Leukemia (CML)- understanding the fundamental pharmacokinetic and pharmacogenetic mechanisms for variation in response
by: Ankathil, Ravindran
Published: (2016)

The Risk of Recurrence in Breast Cancer Patients Treated with Tamoxifen: Polymorphisms of CYP2D6 and ABCB1
by: Teh, L. K., et al.
Published: (2011)

Cloning and expression of CYP2D6*1 and CYP2D6*10 and its application in vitro drug-herbs interaction studies
by: Lee, Wee Leng
Published: (2013)

In vitro study of modulatory effects of Strobilanthes crispus extracts on human cDNA-expressed cytochrome P450 2A6 (CYP2A6) and CYP3A4
by: pan, Yan, et al.
Published: (2016)

High occurrence of CYP3A5 variants among breast cancer and organ transplant patients
by: Ismail, S, et al.
Published: (2010)

Anti-hepatitis a virus seroprev alence among chronic viral hepatitis band c liver disease in husm and its association with cyp3a4*18 polymorphism
by: Fazlina, Ahmad
Published: (2010)

Genetic polymorphism of CYP2C9 in patients on warfarin therapy and the clinical relevance / Teh Lay Kek... [et al.]
by: Teh, Lay Kek, et al.
Published: (2007)

Analysis of T344C genetic polymorphism of CYP11B2 gene in Malaysian end stage renal disease subjects.
by: Vasudevan, R., et al.
Published: (2011)

Molecular Analysis Of Cyp21 Gene In Patients Presenting With Ambiguous Genitalia.
by: Fuziah, M Z, et al.
Published: (2002)

Identifying and targeting dormant cells in acute myeloid leukaemia
by: Yu, N.
Published: (2016)

Less utilized prognostic markers in acute myeloid leukaemia
by: Abdullah, Maha
Published: (2016)