Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity...
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| Format: | Thesis |
| Language: | English |
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2012
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| Online Access: | http://eprints.usm.my/42806/ http://eprints.usm.my/42806/1/THAIGARAJAN_PARUMASIVAM.pdf |
| _version_ | 1848879661947289600 |
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| author | Parumasivam, Thaigarajan |
| author_facet | Parumasivam, Thaigarajan |
| author_sort | Parumasivam, Thaigarajan |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity of INH can be enhanced by augmenting the hydrophilic INH into a hydrophobic/lipophilic compound. Therefore, a series of 13 derivatives with different hydrophobicity were synthesized by adding different hydrophobic acyl chain to the parent compound, INH. |
| first_indexed | 2025-11-15T17:50:47Z |
| format | Thesis |
| id | usm-42806 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:50:47Z |
| publishDate | 2012 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-428062019-04-12T05:26:22Z http://eprints.usm.my/42806/ Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis Parumasivam, Thaigarajan RS1-441 Pharmacy and materia medica The low permeability of the cell envelope against hydrophilic anti-tuberculosis (TB) drugs especially isoniazid (INH), is one of the crucial factors that contribute to the intrinsic resistance in Mycobacterium tuberculosis. Previous studies have floated the idea that the anti-mycobacterial activity of INH can be enhanced by augmenting the hydrophilic INH into a hydrophobic/lipophilic compound. Therefore, a series of 13 derivatives with different hydrophobicity were synthesized by adding different hydrophobic acyl chain to the parent compound, INH. 2012-04 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42806/1/THAIGARAJAN_PARUMASIVAM.pdf Parumasivam, Thaigarajan (2012) Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Parumasivam, Thaigarajan Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis |
| title | Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
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| title_full | Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
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| title_fullStr | Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
|
| title_full_unstemmed | Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
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| title_short | Studies On The Activity Of Isoniazid Derivatives And Their Combinations With Other Anti-TB Drugs On Mycobacterium Tuberculosis
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| title_sort | studies on the activity of isoniazid derivatives and their combinations with other anti-tb drugs on mycobacterium tuberculosis |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/42806/ http://eprints.usm.my/42806/1/THAIGARAJAN_PARUMASIVAM.pdf |