Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan
Infection with HIV results in profound immunologic changes in the infected host. The host immune system becomes dysregulated and profoundly suppressed culminating in a condition known as AIDS. Although this concept is well accepted, the actual immunopathology of the disease is far from established.A...
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| Format: | Conference or Workshop Item |
| Language: | English |
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1999
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| Online Access: | http://eprints.usm.my/42431/ http://eprints.usm.my/42431/1/GP...Status_Pengatifan_Limfosit_Dikalangan_Penagih_-_Penagih_Dadah_%28IVDU%29_Yang_Dijangkiti_HIV_Di_Kelantan...OCR..pdf |
| _version_ | 1848879558669893632 |
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| author | Musa, Mustaffa Nor, Norazmi Mohd Noori, Nazmi Mohd |
| author_facet | Musa, Mustaffa Nor, Norazmi Mohd Noori, Nazmi Mohd |
| author_sort | Musa, Mustaffa |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Infection with HIV results in profound immunologic changes in the infected host. The host immune system becomes dysregulated and profoundly suppressed culminating in a condition known as AIDS. Although this concept is well accepted, the actual immunopathology of the disease is far from established.Accumulated evidence have shown that the activation or misactivation of the immune system itself may contribute to disease progression (Pantaleo and Fauci, 1994).Thus, higher levels of activated CDS+T cells have been shown to correlate with poorer clinical status and
lower CD4+T cell count (Giorgi et al., 1993). Although measurement of the CD4+ T cell level is the current "gold standard" used as a prognostic marker of HIV-disease, it is highly variable among different individuals or even within the same individual.In fact,we have recently demonstrated that the percentage of C04+T cell, a marker suggested to be more stable and less variable than the CD4+T cell absolute count (Taylor et al., 1989) may not necessarily be suitable to be used as a HIV-disease marker for our local stituation (Norazmi and Suam,1994). These data point to the need for separate studies in populations and risk groups other than white homosexual men to identify and clarify prognostic indicators for the development of AIDS. |
| first_indexed | 2025-11-15T17:49:09Z |
| format | Conference or Workshop Item |
| id | usm-42431 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:49:09Z |
| publishDate | 1999 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-424312020-03-20T04:39:12Z http://eprints.usm.my/42431/ Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan Musa, Mustaffa Nor, Norazmi Mohd Noori, Nazmi Mohd RC Internal medicine Infection with HIV results in profound immunologic changes in the infected host. The host immune system becomes dysregulated and profoundly suppressed culminating in a condition known as AIDS. Although this concept is well accepted, the actual immunopathology of the disease is far from established.Accumulated evidence have shown that the activation or misactivation of the immune system itself may contribute to disease progression (Pantaleo and Fauci, 1994).Thus, higher levels of activated CDS+T cells have been shown to correlate with poorer clinical status and lower CD4+T cell count (Giorgi et al., 1993). Although measurement of the CD4+ T cell level is the current "gold standard" used as a prognostic marker of HIV-disease, it is highly variable among different individuals or even within the same individual.In fact,we have recently demonstrated that the percentage of C04+T cell, a marker suggested to be more stable and less variable than the CD4+T cell absolute count (Taylor et al., 1989) may not necessarily be suitable to be used as a HIV-disease marker for our local stituation (Norazmi and Suam,1994). These data point to the need for separate studies in populations and risk groups other than white homosexual men to identify and clarify prognostic indicators for the development of AIDS. 1999 Conference or Workshop Item NonPeerReviewed application/pdf en http://eprints.usm.my/42431/1/GP...Status_Pengatifan_Limfosit_Dikalangan_Penagih_-_Penagih_Dadah_%28IVDU%29_Yang_Dijangkiti_HIV_Di_Kelantan...OCR..pdf Musa, Mustaffa and Nor, Norazmi Mohd and Noori, Nazmi Mohd (1999) Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan. In: Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan. (Submitted) |
| spellingShingle | RC Internal medicine Musa, Mustaffa Nor, Norazmi Mohd Noori, Nazmi Mohd Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan |
| title | Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan |
| title_full | Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan |
| title_fullStr | Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan |
| title_full_unstemmed | Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan |
| title_short | Lymphocyte activation status in HIV infected intravenous drug users (IVDU) in Kelantan |
| title_sort | lymphocyte activation status in hiv infected intravenous drug users (ivdu) in kelantan |
| topic | RC Internal medicine |
| url | http://eprints.usm.my/42431/ http://eprints.usm.my/42431/1/GP...Status_Pengatifan_Limfosit_Dikalangan_Penagih_-_Penagih_Dadah_%28IVDU%29_Yang_Dijangkiti_HIV_Di_Kelantan...OCR..pdf |