Does captopril interrupt compensatory ovarian changes in hemispayed rats
ACE inhibitors are often recommended as the drug of choice to ameliorate essential hypertension. Since the presence of renin-angiotemsin system in the gonadotrophs and the preovulatory fo11ic1e might have a 1ink in ovulatory process, our study has been directed to investigate the possible impact of...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
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1999
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| Online Access: | http://eprints.usm.my/42363/ http://eprints.usm.my/42363/1/GP...Kajian_Tentang_Kemungkinan_Pengaruh_Inhibitor_Enzim_Penukar_Angiotensin_Ke_Atas_Ovulasi..OCR...pdf |
| _version_ | 1848879539744145408 |
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| author | Chatterjjee, Rita Jamalullail, Syed Mohsin Sahil Chatterjee, Amar |
| author_facet | Chatterjjee, Rita Jamalullail, Syed Mohsin Sahil Chatterjee, Amar |
| author_sort | Chatterjjee, Rita |
| building | USM Institutional Repository |
| collection | Online Access |
| description | ACE inhibitors are often recommended as the drug of choice to ameliorate essential hypertension. Since the presence of renin-angiotemsin system in the gonadotrophs and the preovulatory fo11ic1e might have a 1ink in ovulatory process, our study has been directed to investigate the possible impact of ACE inhibitor, if any, at the pituitary-ovarian system.Experimental research schedule and the findings as presented in the conference and a1so pub1ished are as follows Strictly 4-day cyclic rats were subjected to surgical hemi-spaying on day 1 of the cycle, distributed into four groups and treated with either captopirl (ACE inhibitor),captorpirl with prolactin, captopirl with progesterone or the vehicle alone. On the following day 1 of the cycle examination of the fallopian tubes and the ovaries of the animals revealed that 70% of the captopril-treated animals fai1ed to ovu1ate but maintained compensatory,ovarian hypertrophy (40.9 + 3.00 Vs 32.4 + 2.6 mg). The remaining 30% of the same group of animals although showed the sign of ovulation and compensatory ovarian enlargement (41.8 + 2.2 Vs 32.4 ± 2.6 mg), yet the number of eggs ovulated were found to be extremely low in count (1.6 + 0.1 Vs 12.3+ 0.4).Conversely, the groups of. animals which had either prolactin or progesterone concurrent with captopirl showed conspensatory changes in terms of ovulation and ovarian hypertrophy as documented in the vehicle-treated controls. While angiotensin helps in the synthesis and re1ease of pro1actin and the progesterone-primed preovu1atory environment of the fo11ic1e is pro1actin dependent, our findings of captopril induced fai1ure of compensatory ovulation in hemispayed rats suggest that angiotensin converting enzyme inhibitor possibly generates a lesion on the prolactin-progesterone system, an essential system to initiate ovulation. |
| first_indexed | 2025-11-15T17:48:51Z |
| format | Conference or Workshop Item |
| id | usm-42363 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:48:51Z |
| publishDate | 1999 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-423632020-03-20T04:30:48Z http://eprints.usm.my/42363/ Does captopril interrupt compensatory ovarian changes in hemispayed rats Chatterjjee, Rita Jamalullail, Syed Mohsin Sahil Chatterjee, Amar RM Therapeutics. Pharmacology ACE inhibitors are often recommended as the drug of choice to ameliorate essential hypertension. Since the presence of renin-angiotemsin system in the gonadotrophs and the preovulatory fo11ic1e might have a 1ink in ovulatory process, our study has been directed to investigate the possible impact of ACE inhibitor, if any, at the pituitary-ovarian system.Experimental research schedule and the findings as presented in the conference and a1so pub1ished are as follows Strictly 4-day cyclic rats were subjected to surgical hemi-spaying on day 1 of the cycle, distributed into four groups and treated with either captopirl (ACE inhibitor),captorpirl with prolactin, captopirl with progesterone or the vehicle alone. On the following day 1 of the cycle examination of the fallopian tubes and the ovaries of the animals revealed that 70% of the captopril-treated animals fai1ed to ovu1ate but maintained compensatory,ovarian hypertrophy (40.9 + 3.00 Vs 32.4 + 2.6 mg). The remaining 30% of the same group of animals although showed the sign of ovulation and compensatory ovarian enlargement (41.8 + 2.2 Vs 32.4 ± 2.6 mg), yet the number of eggs ovulated were found to be extremely low in count (1.6 + 0.1 Vs 12.3+ 0.4).Conversely, the groups of. animals which had either prolactin or progesterone concurrent with captopirl showed conspensatory changes in terms of ovulation and ovarian hypertrophy as documented in the vehicle-treated controls. While angiotensin helps in the synthesis and re1ease of pro1actin and the progesterone-primed preovu1atory environment of the fo11ic1e is pro1actin dependent, our findings of captopril induced fai1ure of compensatory ovulation in hemispayed rats suggest that angiotensin converting enzyme inhibitor possibly generates a lesion on the prolactin-progesterone system, an essential system to initiate ovulation. 1999 Conference or Workshop Item PeerReviewed application/pdf en http://eprints.usm.my/42363/1/GP...Kajian_Tentang_Kemungkinan_Pengaruh_Inhibitor_Enzim_Penukar_Angiotensin_Ke_Atas_Ovulasi..OCR...pdf Chatterjjee, Rita and Jamalullail, Syed Mohsin Sahil and Chatterjee, Amar (1999) Does captopril interrupt compensatory ovarian changes in hemispayed rats. In: Does captopril interrupt compensatory ovarian changes in hemispayed rats, 26-28 May 1995, Langkawi. (Submitted) |
| spellingShingle | RM Therapeutics. Pharmacology Chatterjjee, Rita Jamalullail, Syed Mohsin Sahil Chatterjee, Amar Does captopril interrupt compensatory ovarian changes in hemispayed rats |
| title | Does captopril interrupt compensatory ovarian changes in hemispayed rats |
| title_full | Does captopril interrupt compensatory ovarian changes in hemispayed rats |
| title_fullStr | Does captopril interrupt compensatory ovarian changes in hemispayed rats |
| title_full_unstemmed | Does captopril interrupt compensatory ovarian changes in hemispayed rats |
| title_short | Does captopril interrupt compensatory ovarian changes in hemispayed rats |
| title_sort | does captopril interrupt compensatory ovarian changes in hemispayed rats |
| topic | RM Therapeutics. Pharmacology |
| url | http://eprints.usm.my/42363/ http://eprints.usm.my/42363/1/GP...Kajian_Tentang_Kemungkinan_Pengaruh_Inhibitor_Enzim_Penukar_Angiotensin_Ke_Atas_Ovulasi..OCR...pdf |