Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis
Capillary zone electrophoresis (CZE) methods for the simultaneous separation of the β-blocker drugs (atenolol (AT), chlorthalidone (CH) and amiloride (AM)), using UV and capacitively coupled contactless conductivity detectors (C4D) were developed and validated. Under the adopted conditions, the anal...
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| Format: | Thesis |
| Language: | English |
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2011
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| Online Access: | http://eprints.usm.my/41894/ http://eprints.usm.my/41894/1/KHALDUN_MOHAMMAD_MITLAQ.pdf |
| _version_ | 1848879412396687360 |
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| author | Al Azzam, Khaldun Mohammad Mitlaq |
| author_facet | Al Azzam, Khaldun Mohammad Mitlaq |
| author_sort | Al Azzam, Khaldun Mohammad Mitlaq |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Capillary zone electrophoresis (CZE) methods for the simultaneous separation of the β-blocker drugs (atenolol (AT), chlorthalidone (CH) and amiloride (AM)), using UV and capacitively coupled contactless conductivity detectors (C4D) were developed and validated. Under the adopted conditions, the analytes were separated in less than 4 min and 7 min for the CZE-UV and the CZE-C4D methods, respectively. The CZE-C4D method has slightly inferior sensitivity, but nevertheless, both methods were successfully applied to the determination of the active ingredients in pharmaceutical preparations. |
| first_indexed | 2025-11-15T17:46:49Z |
| format | Thesis |
| id | usm-41894 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:46:49Z |
| publishDate | 2011 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-418942019-04-12T05:26:40Z http://eprints.usm.my/41894/ Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis Al Azzam, Khaldun Mohammad Mitlaq QD1-999 Chemistry Capillary zone electrophoresis (CZE) methods for the simultaneous separation of the β-blocker drugs (atenolol (AT), chlorthalidone (CH) and amiloride (AM)), using UV and capacitively coupled contactless conductivity detectors (C4D) were developed and validated. Under the adopted conditions, the analytes were separated in less than 4 min and 7 min for the CZE-UV and the CZE-C4D methods, respectively. The CZE-C4D method has slightly inferior sensitivity, but nevertheless, both methods were successfully applied to the determination of the active ingredients in pharmaceutical preparations. 2011 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/41894/1/KHALDUN_MOHAMMAD_MITLAQ.pdf Al Azzam, Khaldun Mohammad Mitlaq (2011) Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | QD1-999 Chemistry Al Azzam, Khaldun Mohammad Mitlaq Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
| title | Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
| title_full | Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
| title_fullStr | Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
| title_full_unstemmed | Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
| title_short | Analytical Method Development And Fundamental Studies On The Separation Of Drugs Using Capillary Electrophoresis |
| title_sort | analytical method development and fundamental studies on the separation of drugs using capillary electrophoresis |
| topic | QD1-999 Chemistry |
| url | http://eprints.usm.my/41894/ http://eprints.usm.my/41894/1/KHALDUN_MOHAMMAD_MITLAQ.pdf |