Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery
Kolon telah dilaporkan sebagai tapak sasaran yang sesuai bagi penyerapan sistemik protein dan peptida terapeutik drug kerana aktiviti peptidase yang lebih rendah, meghampiri pH neutral dan keadaan ‘perbalahan’ yang kurang jika dibandingkan dengan kawasan lain daripada saluran pencernaan. Bentuk dosa...
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| Format: | Thesis |
| Language: | English |
| Published: |
2009
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| Online Access: | http://eprints.usm.my/41554/ http://eprints.usm.my/41554/1/Lim_Vuanghao24.pdf |
| _version_ | 1848879318494609408 |
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| author | Lim , Vuanghao |
| author_facet | Lim , Vuanghao |
| author_sort | Lim , Vuanghao |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Kolon telah dilaporkan sebagai tapak sasaran yang sesuai bagi penyerapan sistemik protein dan peptida terapeutik drug kerana aktiviti peptidase yang lebih rendah, meghampiri pH neutral dan keadaan ‘perbalahan’ yang kurang jika dibandingkan dengan kawasan lain daripada saluran pencernaan. Bentuk dosaj yang diformulasikan mesti melalui saluran pencernaan bahagian atas dalam bentuk utuh sebelum penghantaran drug kepada kolon. Penggunaan polimer disulfida sebagai satu penghantaran responsif bakteria merupakan salah satu strategi untuk menyasarkan drug kepada kolon bagi melepaskan drug secara khusus dalam kolon.
Colon has been reported as a favourable target site for the systemic absorption of therapeutic protein and peptide drugs, because of its lower peptidase activity, near neutral pH and less hostile conditions as compared with other regions of gastrointestinal tract. The formulated dosage form must pass through the upper gastrointestinal tract in intact form before delivering the drug to the colon. The use of disulphide polymers, a bacteria responsive delivery, is one of the strategies for targeting drugs to the colon and to release drug specifically in the colon. |
| first_indexed | 2025-11-15T17:45:20Z |
| format | Thesis |
| id | usm-41554 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:45:20Z |
| publishDate | 2009 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-415542019-04-12T05:26:59Z http://eprints.usm.my/41554/ Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery Lim , Vuanghao RS1-441 Pharmacy and materia medica Kolon telah dilaporkan sebagai tapak sasaran yang sesuai bagi penyerapan sistemik protein dan peptida terapeutik drug kerana aktiviti peptidase yang lebih rendah, meghampiri pH neutral dan keadaan ‘perbalahan’ yang kurang jika dibandingkan dengan kawasan lain daripada saluran pencernaan. Bentuk dosaj yang diformulasikan mesti melalui saluran pencernaan bahagian atas dalam bentuk utuh sebelum penghantaran drug kepada kolon. Penggunaan polimer disulfida sebagai satu penghantaran responsif bakteria merupakan salah satu strategi untuk menyasarkan drug kepada kolon bagi melepaskan drug secara khusus dalam kolon. Colon has been reported as a favourable target site for the systemic absorption of therapeutic protein and peptide drugs, because of its lower peptidase activity, near neutral pH and less hostile conditions as compared with other regions of gastrointestinal tract. The formulated dosage form must pass through the upper gastrointestinal tract in intact form before delivering the drug to the colon. The use of disulphide polymers, a bacteria responsive delivery, is one of the strategies for targeting drugs to the colon and to release drug specifically in the colon. 2009-12 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/41554/1/Lim_Vuanghao24.pdf Lim , Vuanghao (2009) Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Lim , Vuanghao Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery |
| title | Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery |
| title_full | Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery |
| title_fullStr | Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery |
| title_full_unstemmed | Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery |
| title_short | Synthesis And Evaluation Of Cross-Linked Disulphide Containing Polymers For Colonic Drug Delivery |
| title_sort | synthesis and evaluation of cross-linked disulphide containing polymers for colonic drug delivery |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/41554/ http://eprints.usm.my/41554/1/Lim_Vuanghao24.pdf |