Metabolomic Analysis of Blood and Urine to identify Alcohol-Dependence Biomarkers
The clinical diagnosis of alcohol-dependence (AD) currently relies on AD assessment questionnairesand biomarkers such as Carbohydrate-DeficientTransferrin (CDT), Gamma Glutamyl Transferase (GGT) and Phosphatidylethanol (PEth). However, both methods of diagnosis lackspecificity and sensitivity. Metab...
| Main Authors: | , , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | http://eprints.usm.my/40912/ http://eprints.usm.my/40912/1/Abstract-penang_conference_%281%29.pdf |
| Summary: | The clinical diagnosis of alcohol-dependence (AD) currently relies on AD assessment questionnairesand biomarkers such as Carbohydrate-DeficientTransferrin (CDT), Gamma Glutamyl Transferase (GGT) and Phosphatidylethanol (PEth). However, both methods of diagnosis lackspecificity and sensitivity. Metabolic fingerprinting using nuclear magnetic resonance spectroscopy (NMR)of plasma may give us a novel andaccurate method for the diagnosis of the disease. Our primary objective was to identify the metabolites/biomarkers that could discriminate between subjects diagnosed asAD, social drinkersnon-dependent and healthy control. |
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