Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine
Nephrotoxicity is one of the challenging side effects of acyclovir use in clinical practice. The Concomitant use of other nephrotoxic antibiotics, in addition to patient's risk factors, can trigger acyclovir induced acute kidney injury (AKI). We described a case of acute meningitis in 68 year o...
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International Organization of Scientific Resaerch (IOSR)
2014
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| Online Access: | http://eprints.usm.my/40891/ http://eprints.usm.my/40891/1/Acyclovir_Case_report.pdf |
| _version_ | 1848879145187016704 |
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| author | Amin, Arwa M. Ibrahim, Baharudin Sarriff, Azmi |
| author_facet | Amin, Arwa M. Ibrahim, Baharudin Sarriff, Azmi |
| author_sort | Amin, Arwa M. |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Nephrotoxicity is one of the challenging side effects of acyclovir use in clinical practice. The Concomitant use of other nephrotoxic antibiotics, in addition to patient's risk factors, can trigger acyclovir induced acute kidney injury (AKI). We described a case of acute meningitis in 68 year old female patient with underlying history of ischemic heart disease managed by ticlopidine. The gram stain, culture and PCR of the CSF did not show any positive growth of bacterial infection or HSV. However, the negative CSF gram stain and culture caused a confusion of the diagnosis of bacterial meningitis with viral meningitis. The patient had AKI induced by the treatment with acyclovir for 16 consecutive days and possibly triggered by other AKI risk factors. Hemodialysis and hydration did not reverse the kidney function to normal. However, it was reversed to its normal status only after the discontinuation of acyclovir. The neutropenic effect of ticlopidine can be a risk to the patient that could lead to fatal infection. In this case report we reviewed the literature on the nephrotoxicity of acyclovir, the neutropenia of ticlopidine and a proposed role of granulocyte colony stimulating factor (G-CSF). |
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| format | Article |
| id | usm-40891 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:42:34Z |
| publishDate | 2014 |
| publisher | International Organization of Scientific Resaerch (IOSR) |
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| spelling | usm-408912018-07-04T05:05:17Z http://eprints.usm.my/40891/ Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine Amin, Arwa M. Ibrahim, Baharudin Sarriff, Azmi RA643-645 Disease (Communicable and noninfectious) and public health Nephrotoxicity is one of the challenging side effects of acyclovir use in clinical practice. The Concomitant use of other nephrotoxic antibiotics, in addition to patient's risk factors, can trigger acyclovir induced acute kidney injury (AKI). We described a case of acute meningitis in 68 year old female patient with underlying history of ischemic heart disease managed by ticlopidine. The gram stain, culture and PCR of the CSF did not show any positive growth of bacterial infection or HSV. However, the negative CSF gram stain and culture caused a confusion of the diagnosis of bacterial meningitis with viral meningitis. The patient had AKI induced by the treatment with acyclovir for 16 consecutive days and possibly triggered by other AKI risk factors. Hemodialysis and hydration did not reverse the kidney function to normal. However, it was reversed to its normal status only after the discontinuation of acyclovir. The neutropenic effect of ticlopidine can be a risk to the patient that could lead to fatal infection. In this case report we reviewed the literature on the nephrotoxicity of acyclovir, the neutropenia of ticlopidine and a proposed role of granulocyte colony stimulating factor (G-CSF). International Organization of Scientific Resaerch (IOSR) 2014-10 Article PeerReviewed application/pdf en http://eprints.usm.my/40891/1/Acyclovir_Case_report.pdf Amin, Arwa M. and Ibrahim, Baharudin and Sarriff, Azmi (2014) Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine. IOSR Journal Of Pharmacy, 4 (10). pp. 58-62. ISSN 2250-3013 http://www.iosrphr.org/pages/iosrphr.html |
| spellingShingle | RA643-645 Disease (Communicable and noninfectious) and public health Amin, Arwa M. Ibrahim, Baharudin Sarriff, Azmi Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine |
| title | Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine |
| title_full | Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine |
| title_fullStr | Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine |
| title_full_unstemmed | Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine |
| title_short | Acyclovir Induced Acute Kidney Injury In Acute Meningitis Patient: A Case Report Highlights the Concurrence Of AKI Risk Factors And The Neutropenic Effect Of Ticlopidine |
| title_sort | acyclovir induced acute kidney injury in acute meningitis patient: a case report highlights the concurrence of aki risk factors and the neutropenic effect of ticlopidine |
| topic | RA643-645 Disease (Communicable and noninfectious) and public health |
| url | http://eprints.usm.my/40891/ http://eprints.usm.my/40891/ http://eprints.usm.my/40891/1/Acyclovir_Case_report.pdf |