Fibrinolytic Activity and Dose-Dependent Effect of Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester: In Vitro Assays
Background. Caffeic acid phenethyl ester (CAPE) has been reported to possess time-dependent fibrinolytic activity by in vitro assay. This study is aimed at investigating fibrinolytic dose-dependent activity of CAPE using in vitro assays. Methods. Standardized human whole blood (WB) clots were incu...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://eprints.usm.my/39119/ http://eprints.usm.my/39119/1/Fibrinolytic_Activity_and_Dose-Dependent_Effect.pdf |
| _version_ | 1848878657247903744 |
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| author | Elnager, Abuzar Hassan, Rosline Idris, Zamzuri Mustafa, Zulkifli Arfah, Nadiah Wan Sulaiman, S. A. Siew, Hua Gan Abdullah, Wan Zaidah |
| author_facet | Elnager, Abuzar Hassan, Rosline Idris, Zamzuri Mustafa, Zulkifli Arfah, Nadiah Wan Sulaiman, S. A. Siew, Hua Gan Abdullah, Wan Zaidah |
| author_sort | Elnager, Abuzar |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Background. Caffeic acid phenethyl ester (CAPE) has been reported to possess time-dependent fibrinolytic activity by in
vitro assay. This study is aimed at investigating fibrinolytic dose-dependent activity of CAPE using in vitro assays. Methods.
Standardized human whole blood (WB) clots were incubated in either blank controls or different concentrations of CAPE
(3.75, 7.50, 15.00, 22.50, and 30.00mM). After 3 hours, D-dimer (DD) levels and WB clot weights were measured for each
concentration. Thromboelastography (TEG) parameters were recorded following CAPE incubation, and fibrin morphology
was examined under a confocal microscope. Results. Overall, mean DD ( |
| first_indexed | 2025-11-15T17:34:49Z |
| format | Article |
| id | usm-39119 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:34:49Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-391192018-02-22T07:07:06Z http://eprints.usm.my/39119/ Fibrinolytic Activity and Dose-Dependent Effect of Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester: In Vitro Assays Elnager, Abuzar Hassan, Rosline Idris, Zamzuri Mustafa, Zulkifli Arfah, Nadiah Wan Sulaiman, S. A. Siew, Hua Gan Abdullah, Wan Zaidah BD240-260 Methodology RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM Therapeutics. Pharmacology Background. Caffeic acid phenethyl ester (CAPE) has been reported to possess time-dependent fibrinolytic activity by in vitro assay. This study is aimed at investigating fibrinolytic dose-dependent activity of CAPE using in vitro assays. Methods. Standardized human whole blood (WB) clots were incubated in either blank controls or different concentrations of CAPE (3.75, 7.50, 15.00, 22.50, and 30.00mM). After 3 hours, D-dimer (DD) levels and WB clot weights were measured for each concentration. Thromboelastography (TEG) parameters were recorded following CAPE incubation, and fibrin morphology was examined under a confocal microscope. Results. Overall, mean DD ( Hindawi Publishing Corporation 2015 Article PeerReviewed application/pdf en http://eprints.usm.my/39119/1/Fibrinolytic_Activity_and_Dose-Dependent_Effect.pdf Elnager, Abuzar and Hassan, Rosline and Idris, Zamzuri and Mustafa, Zulkifli and Arfah, Nadiah Wan and Sulaiman, S. A. and Siew, Hua Gan and Abdullah, Wan Zaidah (2015) Fibrinolytic Activity and Dose-Dependent Effect of Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester: In Vitro Assays. BioMed Research International, 2015 (627471). pp. 1-10. ISSN 2314-6133 http://dx.doi.org/10.1155/2015/627471 |
| spellingShingle | BD240-260 Methodology RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM Therapeutics. Pharmacology Elnager, Abuzar Hassan, Rosline Idris, Zamzuri Mustafa, Zulkifli Arfah, Nadiah Wan Sulaiman, S. A. Siew, Hua Gan Abdullah, Wan Zaidah Fibrinolytic Activity and Dose-Dependent Effect of Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester: In Vitro Assays |
| title | Fibrinolytic Activity and Dose-Dependent Effect of
Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester:
In Vitro Assays |
| title_full | Fibrinolytic Activity and Dose-Dependent Effect of
Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester:
In Vitro Assays |
| title_fullStr | Fibrinolytic Activity and Dose-Dependent Effect of
Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester:
In Vitro Assays |
| title_full_unstemmed | Fibrinolytic Activity and Dose-Dependent Effect of
Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester:
In Vitro Assays |
| title_short | Fibrinolytic Activity and Dose-Dependent Effect of
Incubating Human Blood Clots in Caffeic Acid Phenethyl Ester:
In Vitro Assays |
| title_sort | fibrinolytic activity and dose-dependent effect of
incubating human blood clots in caffeic acid phenethyl ester:
in vitro assays |
| topic | BD240-260 Methodology RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM Therapeutics. Pharmacology |
| url | http://eprints.usm.my/39119/ http://eprints.usm.my/39119/ http://eprints.usm.my/39119/1/Fibrinolytic_Activity_and_Dose-Dependent_Effect.pdf |