Effects of Ischemic Preconditioning of Different Intraoperative Ischemic Times of Vascularized Bone Graft Rabbit Models
Background Ischemic preconditioning has been shown to improve the outcomes of hypoxic tolerance of the heart, brain, lung, liver, jejunum, skin, and muscle tissues. However, to date, no report of ischemic preconditioning on vascularized bone grafts has been published. Methods Sixteen rabbits were d...
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| Format: | Article |
| Language: | English |
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The Korean Society of Plastic and Reconstructive Surgeons
2013
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| Online Access: | http://eprints.usm.my/38898/ http://eprints.usm.my/38898/1/Effects_of_Ischemic_Preconditioning_of_Different.pdf |
| _version_ | 1848878596581490688 |
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| author | Halim, Ahmad Sukari Wan Ahmad Kamal, Wan Syazli Rodzaian Mohd Noor, Norizal Abdullah, Shafie |
| author_facet | Halim, Ahmad Sukari Wan Ahmad Kamal, Wan Syazli Rodzaian Mohd Noor, Norizal Abdullah, Shafie |
| author_sort | Halim, Ahmad Sukari |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Background Ischemic preconditioning has been shown to improve the outcomes of hypoxic tolerance of the heart, brain, lung, liver, jejunum, skin, and muscle tissues. However, to date, no report of ischemic preconditioning on vascularized bone grafts has been published.
Methods Sixteen rabbits were divided into four groups with ischemic times of 2, 6, 14, and 18 hours. Half of the rabbits in each group underwent ischemic preconditioning. The osteomyocutaneous flaps consisted of the tibia bone, from which the overlying muscle and skin were raised. The technique of ischemic preconditioning involved applying a vascular clamp to the pedicle for 3 cycles of 10 minutes each. The rabbits then underwent serial plain radiography and computed tomography imaging on the first, second, fourth, and sixth postoperative weeks. Following this, all of the rabbits were sacrificed and histological examinations were performed.
Results The results showed that for clinical analysis of the skin flaps and bone grafts, the preconditioned groups showed better survivability. In the plain radiographs, except for two non-preconditioned rabbits with intraoperative ischemic times of 6 hours, all began to show early callus formation at the fourth week. The computed tomography findings showed more callus formation in the preconditioned groups for all of the ischemic times except for the 18-hour group. The histological findings correlated with the radiological findings. There was no statistical significance in the difference between the two groups.
Conclusions In conclusion, ischemic preconditioning improved the survivability of skin flaps and increased callus formation during the healing process of vascularized bone grafts. |
| first_indexed | 2025-11-15T17:33:51Z |
| format | Article |
| id | usm-38898 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:33:51Z |
| publishDate | 2013 |
| publisher | The Korean Society of Plastic and Reconstructive Surgeons |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-388982018-02-14T00:52:26Z http://eprints.usm.my/38898/ Effects of Ischemic Preconditioning of Different Intraoperative Ischemic Times of Vascularized Bone Graft Rabbit Models Halim, Ahmad Sukari Wan Ahmad Kamal, Wan Syazli Rodzaian Mohd Noor, Norizal Abdullah, Shafie R5-130.5 General works Background Ischemic preconditioning has been shown to improve the outcomes of hypoxic tolerance of the heart, brain, lung, liver, jejunum, skin, and muscle tissues. However, to date, no report of ischemic preconditioning on vascularized bone grafts has been published. Methods Sixteen rabbits were divided into four groups with ischemic times of 2, 6, 14, and 18 hours. Half of the rabbits in each group underwent ischemic preconditioning. The osteomyocutaneous flaps consisted of the tibia bone, from which the overlying muscle and skin were raised. The technique of ischemic preconditioning involved applying a vascular clamp to the pedicle for 3 cycles of 10 minutes each. The rabbits then underwent serial plain radiography and computed tomography imaging on the first, second, fourth, and sixth postoperative weeks. Following this, all of the rabbits were sacrificed and histological examinations were performed. Results The results showed that for clinical analysis of the skin flaps and bone grafts, the preconditioned groups showed better survivability. In the plain radiographs, except for two non-preconditioned rabbits with intraoperative ischemic times of 6 hours, all began to show early callus formation at the fourth week. The computed tomography findings showed more callus formation in the preconditioned groups for all of the ischemic times except for the 18-hour group. The histological findings correlated with the radiological findings. There was no statistical significance in the difference between the two groups. Conclusions In conclusion, ischemic preconditioning improved the survivability of skin flaps and increased callus formation during the healing process of vascularized bone grafts. The Korean Society of Plastic and Reconstructive Surgeons 2013-11 Article PeerReviewed application/pdf en http://eprints.usm.my/38898/1/Effects_of_Ischemic_Preconditioning_of_Different.pdf Halim, Ahmad Sukari and Wan Ahmad Kamal, Wan Syazli Rodzaian and Mohd Noor, Norizal and Abdullah, Shafie (2013) Effects of Ischemic Preconditioning of Different Intraoperative Ischemic Times of Vascularized Bone Graft Rabbit Models. Archives of Plastic Surgery, 40 (6). pp. 687-696. ISSN 2234-6163 http://dx.doi.org/10.5999/aps.2013.40.6.687 |
| spellingShingle | R5-130.5 General works Halim, Ahmad Sukari Wan Ahmad Kamal, Wan Syazli Rodzaian Mohd Noor, Norizal Abdullah, Shafie Effects of Ischemic Preconditioning of Different Intraoperative Ischemic Times of Vascularized Bone Graft Rabbit Models |
| title | Effects of Ischemic Preconditioning of Different
Intraoperative Ischemic Times of Vascularized Bone Graft Rabbit Models |
| title_full | Effects of Ischemic Preconditioning of Different
Intraoperative Ischemic Times of Vascularized Bone Graft Rabbit Models |
| title_fullStr | Effects of Ischemic Preconditioning of Different
Intraoperative Ischemic Times of Vascularized Bone Graft Rabbit Models |
| title_full_unstemmed | Effects of Ischemic Preconditioning of Different
Intraoperative Ischemic Times of Vascularized Bone Graft Rabbit Models |
| title_short | Effects of Ischemic Preconditioning of Different
Intraoperative Ischemic Times of Vascularized Bone Graft Rabbit Models |
| title_sort | effects of ischemic preconditioning of different
intraoperative ischemic times of vascularized bone graft rabbit models |
| topic | R5-130.5 General works |
| url | http://eprints.usm.my/38898/ http://eprints.usm.my/38898/ http://eprints.usm.my/38898/1/Effects_of_Ischemic_Preconditioning_of_Different.pdf |