Effect of Calcium Channel Blockers on Lower Urinary Tract Symptoms: A Systematic Review
Background. Numerous medications are known to be associated with the development of lower urinary tract symptoms (LUTS). One such medication group is calcium channel blockers (CCB). Objective. To critically examine the literature regarding the involvement of CCB in manifestation of LUTS in humans....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2017
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| Online Access: | http://eprints.usm.my/38816/ http://eprints.usm.my/38816/1/Effect_of_Calcium_Channel_Blockers_on_Lower_Urinary_Tract_Symptoms_A_Systematic_Review.pdf |
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| author | Salman, Muhammad Khan, Amer Hayat Syed Sulaiman, Syed Azhar Habib Khan, Junaid Hussain, Khalid Shehzadi, Naureen |
| author_facet | Salman, Muhammad Khan, Amer Hayat Syed Sulaiman, Syed Azhar Habib Khan, Junaid Hussain, Khalid Shehzadi, Naureen |
| author_sort | Salman, Muhammad |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Background. Numerous medications are known to be associated with the development of lower urinary tract symptoms (LUTS).
One such medication group is calcium channel blockers (CCB). Objective. To critically examine the literature regarding the
involvement of CCB in manifestation of LUTS in humans. Methods. A systematic literature search was conducted on PubMed,
SciELO, Scopus, and OpenGrey databases to find all potentially relevant research studies before August 2016. Results. Five studies
met the inclusion criteria and were included in this review. Three out of five studies stated that CCB were involved in either
precipitation or exacerbation of LUTS. As for the remaining two studies, one study found out that only the monotherapy of CCB
was associated with increased prevalence of nocturia and voiding symptoms in young females, whereas the other study reported
an inverse association of CCB with LUTS. The methodological quality of studies was considered high for four studies and low for
one study. Conclusion. Healthcare providers should make efforts for an earlier identification of the individuals at risk of LUTS prior
to the commencement of CCB therapy. Moreover, patients should be counselled to notify their healthcare provider if they notice
urinary symptoms after the initiation of CCB. |
| first_indexed | 2025-11-15T17:33:30Z |
| format | Article |
| id | usm-38816 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:33:30Z |
| publishDate | 2017 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-388162018-02-13T02:04:07Z http://eprints.usm.my/38816/ Effect of Calcium Channel Blockers on Lower Urinary Tract Symptoms: A Systematic Review Salman, Muhammad Khan, Amer Hayat Syed Sulaiman, Syed Azhar Habib Khan, Junaid Hussain, Khalid Shehzadi, Naureen RS1-441 Pharmacy and materia medica Background. Numerous medications are known to be associated with the development of lower urinary tract symptoms (LUTS). One such medication group is calcium channel blockers (CCB). Objective. To critically examine the literature regarding the involvement of CCB in manifestation of LUTS in humans. Methods. A systematic literature search was conducted on PubMed, SciELO, Scopus, and OpenGrey databases to find all potentially relevant research studies before August 2016. Results. Five studies met the inclusion criteria and were included in this review. Three out of five studies stated that CCB were involved in either precipitation or exacerbation of LUTS. As for the remaining two studies, one study found out that only the monotherapy of CCB was associated with increased prevalence of nocturia and voiding symptoms in young females, whereas the other study reported an inverse association of CCB with LUTS. The methodological quality of studies was considered high for four studies and low for one study. Conclusion. Healthcare providers should make efforts for an earlier identification of the individuals at risk of LUTS prior to the commencement of CCB therapy. Moreover, patients should be counselled to notify their healthcare provider if they notice urinary symptoms after the initiation of CCB. Hindawi Publishing Corporation 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/38816/1/Effect_of_Calcium_Channel_Blockers_on_Lower_Urinary_Tract_Symptoms_A_Systematic_Review.pdf Salman, Muhammad and Khan, Amer Hayat and Syed Sulaiman, Syed Azhar and Habib Khan, Junaid and Hussain, Khalid and Shehzadi, Naureen (2017) Effect of Calcium Channel Blockers on Lower Urinary Tract Symptoms: A Systematic Review. BioMed Research International, 2017 (426987). pp. 1-7. ISSN 2314-6133 https://doi.org/10.1155/2017/4269875 |
| spellingShingle | RS1-441 Pharmacy and materia medica Salman, Muhammad Khan, Amer Hayat Syed Sulaiman, Syed Azhar Habib Khan, Junaid Hussain, Khalid Shehzadi, Naureen Effect of Calcium Channel Blockers on Lower Urinary Tract Symptoms: A Systematic Review |
| title | Effect of Calcium Channel Blockers on Lower Urinary Tract
Symptoms: A Systematic Review |
| title_full | Effect of Calcium Channel Blockers on Lower Urinary Tract
Symptoms: A Systematic Review |
| title_fullStr | Effect of Calcium Channel Blockers on Lower Urinary Tract
Symptoms: A Systematic Review |
| title_full_unstemmed | Effect of Calcium Channel Blockers on Lower Urinary Tract
Symptoms: A Systematic Review |
| title_short | Effect of Calcium Channel Blockers on Lower Urinary Tract
Symptoms: A Systematic Review |
| title_sort | effect of calcium channel blockers on lower urinary tract
symptoms: a systematic review |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/38816/ http://eprints.usm.my/38816/ http://eprints.usm.my/38816/1/Effect_of_Calcium_Channel_Blockers_on_Lower_Urinary_Tract_Symptoms_A_Systematic_Review.pdf |