Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering
P(3HB-co-4HB) copolymer was modified using collagen by adapting dual solvent system. The surface properties of samples were characterized by Fourier transforminfrared spectroscopy (FTIR), scanning electron microscopy (SEM), organic elemental analysis (CHN analysis), and water contact angle measure...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://eprints.usm.my/38636/ http://eprints.usm.my/38636/1/Design_of_a_new_hybrid_artificial_neural_network_method_based_on_decision_trees.pdf |
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| author | S., Vigneswari H. P. S., Abdul Khalil A. A., Amirul |
| author_facet | S., Vigneswari H. P. S., Abdul Khalil A. A., Amirul |
| author_sort | S., Vigneswari |
| building | USM Institutional Repository |
| collection | Online Access |
| description | P(3HB-co-4HB) copolymer was modified using collagen by adapting dual solvent system. The surface properties of samples were
characterized by Fourier transforminfrared spectroscopy (FTIR), scanning electron microscopy (SEM), organic elemental analysis
(CHN analysis), and water contact angle measurements.The effects of collagen concentration, scaffold thickness, and 4HB molar
fraction on the hydrophilicitywere optimized by the Taguchi method.The orthogonal array experiment was conducted to obtain the
response for a hydrophilic scaffold. Analysis of variance (ANOVA) was used to determine the significant parameters and determine
the optimal level for each parameter. The results also showed that the hydrophilicity of P(3HB-co-4HB)/collagen blend scaffolds
increased as the collagen concentration increased up to 15 wt% with a molar fraction of 50mol% at 0.1mm scaffold thickness. The
biocompatibility of the P(3HB-co-4HB)/collagen blend surface was evaluated by fibroblast cell (L929) culture.The collagen blend
scaffold surfaces showed significant cell adhesion and growth as compared to P(3HB-co-4HB) copolymer scaffolds. |
| first_indexed | 2025-11-15T17:32:43Z |
| format | Article |
| id | usm-38636 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:32:43Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-386362018-02-01T06:43:59Z http://eprints.usm.my/38636/ Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering S., Vigneswari H. P. S., Abdul Khalil A. A., Amirul QH1 Natural history (General - Including nature conservation, geographical distribution) T1-995 Technology(General) P(3HB-co-4HB) copolymer was modified using collagen by adapting dual solvent system. The surface properties of samples were characterized by Fourier transforminfrared spectroscopy (FTIR), scanning electron microscopy (SEM), organic elemental analysis (CHN analysis), and water contact angle measurements.The effects of collagen concentration, scaffold thickness, and 4HB molar fraction on the hydrophilicitywere optimized by the Taguchi method.The orthogonal array experiment was conducted to obtain the response for a hydrophilic scaffold. Analysis of variance (ANOVA) was used to determine the significant parameters and determine the optimal level for each parameter. The results also showed that the hydrophilicity of P(3HB-co-4HB)/collagen blend scaffolds increased as the collagen concentration increased up to 15 wt% with a molar fraction of 50mol% at 0.1mm scaffold thickness. The biocompatibility of the P(3HB-co-4HB)/collagen blend surface was evaluated by fibroblast cell (L929) culture.The collagen blend scaffold surfaces showed significant cell adhesion and growth as compared to P(3HB-co-4HB) copolymer scaffolds. Hindawi Publishing Corporation 2015 Article PeerReviewed application/pdf en http://eprints.usm.my/38636/1/Design_of_a_new_hybrid_artificial_neural_network_method_based_on_decision_trees.pdf S., Vigneswari and H. P. S., Abdul Khalil and A. A., Amirul (2015) Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering. International Journal of Polymer Science, 2015 (731690). pp. 1-10. ISSN 1687-9422 http://dx.doi.org/10.1155/2015/731690 |
| spellingShingle | QH1 Natural history (General - Including nature conservation, geographical distribution) T1-995 Technology(General) S., Vigneswari H. P. S., Abdul Khalil A. A., Amirul Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering |
| title | Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering |
| title_full | Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering |
| title_fullStr | Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering |
| title_full_unstemmed | Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering |
| title_short | Designing of Collagen Based Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) Scaffolds for Tissue Engineering |
| title_sort | designing of collagen based poly(3-hydroxybutyrate-co-4-hydroxybutyrate) scaffolds for tissue engineering |
| topic | QH1 Natural history (General - Including nature conservation, geographical distribution) T1-995 Technology(General) |
| url | http://eprints.usm.my/38636/ http://eprints.usm.my/38636/ http://eprints.usm.my/38636/1/Design_of_a_new_hybrid_artificial_neural_network_method_based_on_decision_trees.pdf |