Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats
Wounds with full-thickness skin loss are commonly managed by skin grafting. In the absence of a graft, reepithelialization is imperfect and leads to increased scar formation. Biomaterials can alter wound healing so that it produces more regenerative tissue and fewer scars. This current study use t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2013
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| Online Access: | http://eprints.usm.my/38443/ http://eprints.usm.my/38443/1/Chitosan_Dermal_Substitute_and_Chitosan_Skin_Substitute_Contribute_to_Accelerated.pdf |
| _version_ | 1848878470704136192 |
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| author | Abu Bakar, Mohd Hilmi Halim, Ahmad Sukari Jaafar, Hasnan Abu Bakar, Asiah Hassan, Asma |
| author_facet | Abu Bakar, Mohd Hilmi Halim, Ahmad Sukari Jaafar, Hasnan Abu Bakar, Asiah Hassan, Asma |
| author_sort | Abu Bakar, Mohd Hilmi |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Wounds with full-thickness skin loss are commonly managed by skin grafting. In the absence of a graft, reepithelialization is
imperfect and leads to increased scar formation. Biomaterials can alter wound healing so that it produces more regenerative tissue
and fewer scars. This current study use the new chitosan based biomaterial in full-thickness wound with impaired healing on rat
model.Wounds were evaluated after being treated with a chitosan dermal substitute, a chitosan skin substitute, or duoderm CGF.
Wounds treated with the chitosan skin substitute showed the most re-epithelialization (33.2 ± 2.8%), longest epithelial tongue (1.62
± 0.13 mm), and shortest migratory tongue distance (7.11 ± 0.25 mm). The scar size of wounds treated with the chitosan dermal
substitute (0.13 ± 0.02 cm) and chitosan skin substitute (0.16 ± 0.05 cm) were significantly decreased ( |
| first_indexed | 2025-11-15T17:31:51Z |
| format | Article |
| id | usm-38443 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:31:51Z |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-384432018-01-19T07:25:14Z http://eprints.usm.my/38443/ Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats Abu Bakar, Mohd Hilmi Halim, Ahmad Sukari Jaafar, Hasnan Abu Bakar, Asiah Hassan, Asma RK1-715 Dentistry Wounds with full-thickness skin loss are commonly managed by skin grafting. In the absence of a graft, reepithelialization is imperfect and leads to increased scar formation. Biomaterials can alter wound healing so that it produces more regenerative tissue and fewer scars. This current study use the new chitosan based biomaterial in full-thickness wound with impaired healing on rat model.Wounds were evaluated after being treated with a chitosan dermal substitute, a chitosan skin substitute, or duoderm CGF. Wounds treated with the chitosan skin substitute showed the most re-epithelialization (33.2 ± 2.8%), longest epithelial tongue (1.62 ± 0.13 mm), and shortest migratory tongue distance (7.11 ± 0.25 mm). The scar size of wounds treated with the chitosan dermal substitute (0.13 ± 0.02 cm) and chitosan skin substitute (0.16 ± 0.05 cm) were significantly decreased ( Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://eprints.usm.my/38443/1/Chitosan_Dermal_Substitute_and_Chitosan_Skin_Substitute_Contribute_to_Accelerated.pdf Abu Bakar, Mohd Hilmi and Halim, Ahmad Sukari and Jaafar, Hasnan and Abu Bakar, Asiah and Hassan, Asma (2013) Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats. BioMed Research International, 2013 (795458). pp. 1-13. ISSN 2314-6133 http://dx.doi.org/10.1155/2013/795458 |
| spellingShingle | RK1-715 Dentistry Abu Bakar, Mohd Hilmi Halim, Ahmad Sukari Jaafar, Hasnan Abu Bakar, Asiah Hassan, Asma Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats |
| title | Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats |
| title_full | Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats |
| title_fullStr | Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats |
| title_full_unstemmed | Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats |
| title_short | Chitosan Dermal Substitute and Chitosan Skin Substitute Contribute to Accelerated Full-Thickness Wound Healing in Irradiated Rats |
| title_sort | chitosan dermal substitute and chitosan skin substitute contribute to accelerated full-thickness wound healing in irradiated rats |
| topic | RK1-715 Dentistry |
| url | http://eprints.usm.my/38443/ http://eprints.usm.my/38443/ http://eprints.usm.my/38443/1/Chitosan_Dermal_Substitute_and_Chitosan_Skin_Substitute_Contribute_to_Accelerated.pdf |