Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine
phosphatase 1B

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Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B

Prior to its total synthesis, a new vanadium coordination compound, called TSAG0101, was computationally designed to inhibit the enzyme protein tyrosine phosphatase 1B (PTP1B). The PTP1B acts as a negative regulator of insulin signaling by blocking the active site where phosphate hydrolysis of th...

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Bibliographic Details
Main Authors:	Thomas, Scior, José Antonio, Guevara García, FJ, Melendez, H Abdallah, Hassan, Do, Quoc Tuan, Philippe, Bernard
Format:	Article
Language:	English
Published:	Dove Medical Press 2010
Subjects:	QD1-999 Chemistry
Online Access:	http://eprints.usm.my/38442/ http://eprints.usm.my/38442/1/Chimeric_design%2C_synthesis%2C_and_biological_assays_of_a.pdf

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