Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels
The present study was designed to investigate the cardioprotective effects ofMalaysian Tualang honey against isoproterenol- (ISO-) induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I (cTnI), triglycerides (TG), total chole...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://eprints.usm.my/38415/ http://eprints.usm.my/38415/1/Cardioprotective_Effects_of_Tualang_Honey.pdf |
| _version_ | 1848878462926848000 |
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| author | Khalil, Md. Ibrahim Tanvir, E. M. Afroz, Rizwana Sulaiman, Siti Amrah Siew, Hua Gan |
| author_facet | Khalil, Md. Ibrahim Tanvir, E. M. Afroz, Rizwana Sulaiman, Siti Amrah Siew, Hua Gan |
| author_sort | Khalil, Md. Ibrahim |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The present study was designed to investigate the cardioprotective effects ofMalaysian Tualang honey against isoproterenol- (ISO-)
induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I
(cTnI), triglycerides (TG), total cholesterol (TC), lipid peroxidation (LPO) products, and antioxidant defense system combined
with histopathological examination.Male albinoWistar rats (n = 40) were pretreated orally with Tualang honey (3 g/kg/day) for 45
days. Subcutaneous injection of ISO (85mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac
marker enzymes (creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate transaminase (AST)), cTnI, serum
TC, and TG levels. In addition, ISO-induced myocardial injury was confirmed by a significant increase in heart lipid peroxidation
(LPO) products (TBARS) and a significant decrease in antioxidant enzymes (SOD, GPx, GRx, and GST). Pretreatment of ischemic
rats with Tualang honey conferred significant protective effects on all of the investigated biochemical parameters.The biochemical
findings were further confirmed by histopathological examination in both Tualang-honey-pretreated and ISO-treated hearts. The
present study demonstrates that Tualang honey confers cardioprotective effects on ISO-induced oxidative stress by contributing to
endogenous antioxidant enzyme activity via inhibition of lipid peroxidation. |
| first_indexed | 2025-11-15T17:31:44Z |
| format | Article |
| id | usm-38415 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:31:44Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-384152018-01-17T08:17:19Z http://eprints.usm.my/38415/ Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels Khalil, Md. Ibrahim Tanvir, E. M. Afroz, Rizwana Sulaiman, Siti Amrah Siew, Hua Gan RM Therapeutics. Pharmacology The present study was designed to investigate the cardioprotective effects ofMalaysian Tualang honey against isoproterenol- (ISO-) induced myocardial infarction (MI) in rats by investigating changes in the levels of cardiac marker enzymes, cardiac troponin I (cTnI), triglycerides (TG), total cholesterol (TC), lipid peroxidation (LPO) products, and antioxidant defense system combined with histopathological examination.Male albinoWistar rats (n = 40) were pretreated orally with Tualang honey (3 g/kg/day) for 45 days. Subcutaneous injection of ISO (85mg/kg in saline) for two consecutive days caused a significant increase in serum cardiac marker enzymes (creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), and aspartate transaminase (AST)), cTnI, serum TC, and TG levels. In addition, ISO-induced myocardial injury was confirmed by a significant increase in heart lipid peroxidation (LPO) products (TBARS) and a significant decrease in antioxidant enzymes (SOD, GPx, GRx, and GST). Pretreatment of ischemic rats with Tualang honey conferred significant protective effects on all of the investigated biochemical parameters.The biochemical findings were further confirmed by histopathological examination in both Tualang-honey-pretreated and ISO-treated hearts. The present study demonstrates that Tualang honey confers cardioprotective effects on ISO-induced oxidative stress by contributing to endogenous antioxidant enzyme activity via inhibition of lipid peroxidation. Hindawi Publishing Corporation 2015 Article PeerReviewed application/pdf en http://eprints.usm.my/38415/1/Cardioprotective_Effects_of_Tualang_Honey.pdf Khalil, Md. Ibrahim and Tanvir, E. M. and Afroz, Rizwana and Sulaiman, Siti Amrah and Siew, Hua Gan (2015) Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels. BioMed Research International, 2015 (286051). pp. 1-8. ISSN 2314-6133 http://dx.doi.org/10.1155/2015/286051 |
| spellingShingle | RM Therapeutics. Pharmacology Khalil, Md. Ibrahim Tanvir, E. M. Afroz, Rizwana Sulaiman, Siti Amrah Siew, Hua Gan Cardioprotective Effects of Tualang Honey: Amelioration of Cholesterol and Cardiac Enzymes Levels |
| title | Cardioprotective Effects of Tualang Honey: Amelioration of
Cholesterol and Cardiac Enzymes Levels |
| title_full | Cardioprotective Effects of Tualang Honey: Amelioration of
Cholesterol and Cardiac Enzymes Levels |
| title_fullStr | Cardioprotective Effects of Tualang Honey: Amelioration of
Cholesterol and Cardiac Enzymes Levels |
| title_full_unstemmed | Cardioprotective Effects of Tualang Honey: Amelioration of
Cholesterol and Cardiac Enzymes Levels |
| title_short | Cardioprotective Effects of Tualang Honey: Amelioration of
Cholesterol and Cardiac Enzymes Levels |
| title_sort | cardioprotective effects of tualang honey: amelioration of
cholesterol and cardiac enzymes levels |
| topic | RM Therapeutics. Pharmacology |
| url | http://eprints.usm.my/38415/ http://eprints.usm.my/38415/ http://eprints.usm.my/38415/1/Cardioprotective_Effects_of_Tualang_Honey.pdf |