BoneMicro-CT Assessments in an Orchidectomised RatModel Supplemented with Eurycoma longifolia
Recent studies suggested that Eurycoma longifolia, a herbal plant, may have the potential to treat osteoporosis in elderly male. This study aimed to determine the effects of Eurycoma longifolia supplementation on the trabecular bone microarchitecture of orchidectomised rats (androgen-deficient ost...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2012
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| Subjects: | |
| Online Access: | http://eprints.usm.my/38407/ http://eprints.usm.my/38407/1/Bone_Micro-CT_Assessments_in_an_Orchidectomised_Rat_Model_Supplemented_with.pdf |
| Summary: | Recent studies suggested that Eurycoma longifolia, a herbal plant, may have the potential to treat osteoporosis in elderly male.
This study aimed to determine the effects of Eurycoma longifolia supplementation on the trabecular bone microarchitecture of
orchidectomised rats (androgen-deficient osteoporosis model). Forty-eight-aged (10–12 months old) Sprague Dawley rats were
divided into six groups of sham-operated (SHAM), orchidectomised control (ORX), orchidectomised + 7mg/rat testosterone
enanthate (TEN) and orchidectomised + Eurycoma longifolia 30 mg/kg (EL30), orchidectomised + Eurycoma longifolia 60 mg/kg
(EL60), orchidectomised + Eurycoma longifolia 90 mg/kg (EL90). Rats were euthanized following six weeks of treatment. The
left femora were used to measure the trabecular bone microarchitecture using micro-CT. Orchidectomy significantly decreased
connectivity density, trabecular bone volume, and trabecular number compared to the SHAM group. Testosterone replacement
reversed all the orchidectomy-induced changes in the micro-CT parameters. EL at 30 and 60 mg/kg rat worsened the trabecular
bone connectivity density and trabecular separation parameters of orchidectomised rats. EL at 90 mg/kg rat preserved the bone
volume. High dose of EL (90 mg/kg) may have potential in preserving the bone microarchitecture of orchidectomised rats, but
lower doses may further worsen the osteoporotic changes. |
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