Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines
Complementarymedicine using natural product as antitumor is on the rise.Much research has been performed on Tualang Honey and it was shown to have therapeutic potential in wound healing, and antimicrobial activity and be antiproliferative against several cancer models such as human osteosarcoma (H...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://eprints.usm.my/38334/ http://eprints.usm.my/38334/1/Antileukemic_Effect_of_Tualang_Honey_on_Acute_and_Chronic_Leukemia_Cell_Lines.pdf |
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| author | Nik Man, Nik Muhd Khuzaimi Hassan, Rosline Cheng, Yong Ang Abdullah, Abu Dzarr Ganesh Mohd Radzi, Muhammad Amiro Rasheeq Sulaiman, Siti Amrah |
| author_facet | Nik Man, Nik Muhd Khuzaimi Hassan, Rosline Cheng, Yong Ang Abdullah, Abu Dzarr Ganesh Mohd Radzi, Muhammad Amiro Rasheeq Sulaiman, Siti Amrah |
| author_sort | Nik Man, Nik Muhd Khuzaimi |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Complementarymedicine using natural product as antitumor is on the rise.Much research has been performed on Tualang Honey
and it was shown to have therapeutic potential in wound healing, and antimicrobial activity and be antiproliferative against several
cancer models such as human osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231), and cervical (HeLa) cancer cell
lines. To date, there was limited study on antileukemic properties of Tualang (Koompassia excelsa) Honey. The aim of this study
was to evaluate the antileukemic effect of Tualang Honey on acute and chronic leukemia cell lines. Leukemia cell lines (K562
and MV4-11) and human mononuclear cell isolated from peripheral blood were grown in RPM1 1640 culture medium. The cells
were incubated with increasing concentrations of Tualang Honey. After incubation, the evaluation of viability and apoptosis was
performed. The morphological changes of leukemia cells were the presence of cytoplasmic blebs followed by apoptotic bodies and
round shape of cells. IC50 against K562 and MV4-11 was determined. Tualang Honey gave 53.9% and 50.6% apoptosis activity on
K562 and MV4-11, respectively, while on human mononuclear cell it was 37.4%. Tualang Honey has the apoptosis-inducing ability
for acute and chronic myeloid leukemia (K562 and MV4-11) cell lines. |
| first_indexed | 2025-11-15T17:31:21Z |
| format | Article |
| id | usm-38334 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:31:21Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-383342018-01-11T00:38:55Z http://eprints.usm.my/38334/ Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines Nik Man, Nik Muhd Khuzaimi Hassan, Rosline Cheng, Yong Ang Abdullah, Abu Dzarr Ganesh Mohd Radzi, Muhammad Amiro Rasheeq Sulaiman, Siti Amrah RM Therapeutics. Pharmacology Complementarymedicine using natural product as antitumor is on the rise.Much research has been performed on Tualang Honey and it was shown to have therapeutic potential in wound healing, and antimicrobial activity and be antiproliferative against several cancer models such as human osteosarcoma (HOS), human breast (MCF-7 and MDA-MB-231), and cervical (HeLa) cancer cell lines. To date, there was limited study on antileukemic properties of Tualang (Koompassia excelsa) Honey. The aim of this study was to evaluate the antileukemic effect of Tualang Honey on acute and chronic leukemia cell lines. Leukemia cell lines (K562 and MV4-11) and human mononuclear cell isolated from peripheral blood were grown in RPM1 1640 culture medium. The cells were incubated with increasing concentrations of Tualang Honey. After incubation, the evaluation of viability and apoptosis was performed. The morphological changes of leukemia cells were the presence of cytoplasmic blebs followed by apoptotic bodies and round shape of cells. IC50 against K562 and MV4-11 was determined. Tualang Honey gave 53.9% and 50.6% apoptosis activity on K562 and MV4-11, respectively, while on human mononuclear cell it was 37.4%. Tualang Honey has the apoptosis-inducing ability for acute and chronic myeloid leukemia (K562 and MV4-11) cell lines. Hindawi Publishing Corporation 2015 Article PeerReviewed application/pdf en http://eprints.usm.my/38334/1/Antileukemic_Effect_of_Tualang_Honey_on_Acute_and_Chronic_Leukemia_Cell_Lines.pdf Nik Man, Nik Muhd Khuzaimi and Hassan, Rosline and Cheng, Yong Ang and Abdullah, Abu Dzarr Ganesh and Mohd Radzi, Muhammad Amiro Rasheeq and Sulaiman, Siti Amrah (2015) Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines. BioMed Research International, 2015 (307094). pp. 1-7. ISSN 2314-6133 http://dx.doi.org/10.1155/2015/307094 |
| spellingShingle | RM Therapeutics. Pharmacology Nik Man, Nik Muhd Khuzaimi Hassan, Rosline Cheng, Yong Ang Abdullah, Abu Dzarr Ganesh Mohd Radzi, Muhammad Amiro Rasheeq Sulaiman, Siti Amrah Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines |
| title | Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines |
| title_full | Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines |
| title_fullStr | Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines |
| title_full_unstemmed | Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines |
| title_short | Antileukemic Effect of Tualang Honey on Acute and Chronic Leukemia Cell Lines |
| title_sort | antileukemic effect of tualang honey on acute and chronic leukemia cell lines |
| topic | RM Therapeutics. Pharmacology |
| url | http://eprints.usm.my/38334/ http://eprints.usm.my/38334/ http://eprints.usm.my/38334/1/Antileukemic_Effect_of_Tualang_Honey_on_Acute_and_Chronic_Leukemia_Cell_Lines.pdf |