Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical Performance of Multi-Ethnic Malaysian Population
A disparity population data set in the current literature with limited reports among Asian samples and the inconsistent findings among different ethnic groups warrant further investigation on the association between alpha-actinin-3 (ACTN3) R/X gene polymorphism and human physical performance in A...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Asian Exercise and Sport Science Association
2016
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| Online Access: | http://eprints.usm.my/38278/ http://eprints.usm.my/38278/1/Alpha-Actinin-3_%28ACTN3%29_RXGene_Polymorphism_and_Physical.pdf |
| _version_ | 1848878423781408768 |
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| author | Ahmad Yusof, Hazwani Singh, Rabindarjeet Zainuddin, Zafarina Rooney, Kieron Che Muhamad, Ahmad Munir |
| author_facet | Ahmad Yusof, Hazwani Singh, Rabindarjeet Zainuddin, Zafarina Rooney, Kieron Che Muhamad, Ahmad Munir |
| author_sort | Ahmad Yusof, Hazwani |
| building | USM Institutional Repository |
| collection | Online Access |
| description | A disparity population data set in the current literature with limited reports among Asian samples
and the inconsistent findings among different ethnic groups warrant further investigation on the
association between alpha-actinin-3 (ACTN3) R/X gene polymorphism and human physical
performance in Asian population. This study was designed to examine the association between
ACTN3 R/X gene polymorphism and physical performance of multi-ethnic Malaysian population.
One hundred eighty well-trained athletes (34 endurance, 41 strength, and 105 intermittent) and
180 controls were drawn from four ethnic groups in Malaysia (Malay, Chinese, Indian, and Other
Bumiputra). A sample of deoxyribonucleic acid (DNA) was retrieved from a buccal swab from
each participant and the ACTN3 R/X genotype was identified through polymerase chain reaction
and restriction fragment length polymorphism analysis. The strength and endurance performances
of the athletes were evaluated with maximal voluntary contraction and Yo-Yo intermittent
recovery level 2 tests, respectively. The independent t-test, chi-square, multivariate, and one-way
analysis of variance were used for data analysis. ACTN3 R/X alleles (p = 0.672) and genotype (p
= 0.355) frequencies did not vary much between the multi-ethnic groups of Malaysian athletes.
These small variations did not have any influence on handgrip strength (p = 0.334), leg strength
(p = 0.256), and Yo-Yo intermittent recovery level 2 performance (p = 0.425) between these ethnic
groups. The RR and XX genotypes were more frequent among strength and intermittent athletes,
respectively. Athletes with the RR genotype had greater handgrip than those with the RX genotype
(p = 0.031), but not different from athletes with the XX genotype (p = 0.228). |
| first_indexed | 2025-11-15T17:31:06Z |
| format | Article |
| id | usm-38278 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:31:06Z |
| publishDate | 2016 |
| publisher | Asian Exercise and Sport Science Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-382782018-01-08T05:02:45Z http://eprints.usm.my/38278/ Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical Performance of Multi-Ethnic Malaysian Population Ahmad Yusof, Hazwani Singh, Rabindarjeet Zainuddin, Zafarina Rooney, Kieron Che Muhamad, Ahmad Munir QD415-436 Biochemistry RK1-715 Dentistry A disparity population data set in the current literature with limited reports among Asian samples and the inconsistent findings among different ethnic groups warrant further investigation on the association between alpha-actinin-3 (ACTN3) R/X gene polymorphism and human physical performance in Asian population. This study was designed to examine the association between ACTN3 R/X gene polymorphism and physical performance of multi-ethnic Malaysian population. One hundred eighty well-trained athletes (34 endurance, 41 strength, and 105 intermittent) and 180 controls were drawn from four ethnic groups in Malaysia (Malay, Chinese, Indian, and Other Bumiputra). A sample of deoxyribonucleic acid (DNA) was retrieved from a buccal swab from each participant and the ACTN3 R/X genotype was identified through polymerase chain reaction and restriction fragment length polymorphism analysis. The strength and endurance performances of the athletes were evaluated with maximal voluntary contraction and Yo-Yo intermittent recovery level 2 tests, respectively. The independent t-test, chi-square, multivariate, and one-way analysis of variance were used for data analysis. ACTN3 R/X alleles (p = 0.672) and genotype (p = 0.355) frequencies did not vary much between the multi-ethnic groups of Malaysian athletes. These small variations did not have any influence on handgrip strength (p = 0.334), leg strength (p = 0.256), and Yo-Yo intermittent recovery level 2 performance (p = 0.425) between these ethnic groups. The RR and XX genotypes were more frequent among strength and intermittent athletes, respectively. Athletes with the RR genotype had greater handgrip than those with the RX genotype (p = 0.031), but not different from athletes with the XX genotype (p = 0.228). Asian Exercise and Sport Science Association 2016-09 Article PeerReviewed application/pdf en http://eprints.usm.my/38278/1/Alpha-Actinin-3_%28ACTN3%29_RXGene_Polymorphism_and_Physical.pdf Ahmad Yusof, Hazwani and Singh, Rabindarjeet and Zainuddin, Zafarina and Rooney, Kieron and Che Muhamad, Ahmad Munir (2016) Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical Performance of Multi-Ethnic Malaysian Population. International Journal of Applied Exercise Physiology, 5 (3). pp. 18-30. ISSN 2322-3537 http://www.ijaep.com/index.php/IJAE/article/view/78 |
| spellingShingle | QD415-436 Biochemistry RK1-715 Dentistry Ahmad Yusof, Hazwani Singh, Rabindarjeet Zainuddin, Zafarina Rooney, Kieron Che Muhamad, Ahmad Munir Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical Performance of Multi-Ethnic Malaysian Population |
| title | Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical
Performance of Multi-Ethnic Malaysian Population |
| title_full | Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical
Performance of Multi-Ethnic Malaysian Population |
| title_fullStr | Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical
Performance of Multi-Ethnic Malaysian Population |
| title_full_unstemmed | Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical
Performance of Multi-Ethnic Malaysian Population |
| title_short | Alpha-Actinin-3 (ACTN3) R/X Gene Polymorphism and Physical
Performance of Multi-Ethnic Malaysian Population |
| title_sort | alpha-actinin-3 (actn3) r/x gene polymorphism and physical
performance of multi-ethnic malaysian population |
| topic | QD415-436 Biochemistry RK1-715 Dentistry |
| url | http://eprints.usm.my/38278/ http://eprints.usm.my/38278/ http://eprints.usm.my/38278/1/Alpha-Actinin-3_%28ACTN3%29_RXGene_Polymorphism_and_Physical.pdf |