Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats
Despite Euphorbia hirta L. ethnomedicinal benefits, very few studies have described the potential toxicity.The aim of the present study was to evaluate the in vivo toxicity of methanolic extracts of E. hirta.The acute and subchronic oral toxicity of E. hirta was evaluated in Sprague Dawley rats. T...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2013
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| Online Access: | http://eprints.usm.my/38244/ http://eprints.usm.my/38244/1/Acute_and_Subchronic_Toxicity_Study_of_Euphorbia_hirta_L._Methanol_Extract_in_Rats.pdf |
| _version_ | 1848878414214201344 |
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| author | Kwan, Yuet Ping Ibrahim, Darah Yeng, Chen Subramaniam, Sreeramanan Sreenivasan, Sasidharan |
| author_facet | Kwan, Yuet Ping Ibrahim, Darah Yeng, Chen Subramaniam, Sreeramanan Sreenivasan, Sasidharan |
| author_sort | Kwan, Yuet Ping |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Despite Euphorbia hirta L. ethnomedicinal benefits, very few studies have described the potential toxicity.The aim of the present
study was to evaluate the in vivo toxicity of methanolic extracts of E. hirta.The acute and subchronic oral toxicity of E. hirta was
evaluated in Sprague Dawley rats. The extract at a single dose of 5000mg/kg did not produce treatment related signs of toxicity
or mortality in any of the animals tested during the 14-day observation period. Therefore, the LD 50 of this plant was estimated
to be more than 5000mg/kg. In the repeated dose 90-day oral toxicity study, the administration of 50mg/kg, 250mg/kg, and
1000mg/kg/day of E. hirta extract per body weight revealed no significant difference ( |
| first_indexed | 2025-11-15T17:30:57Z |
| format | Article |
| id | usm-38244 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:30:57Z |
| publishDate | 2013 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-382442018-01-05T01:40:34Z http://eprints.usm.my/38244/ Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats Kwan, Yuet Ping Ibrahim, Darah Yeng, Chen Subramaniam, Sreeramanan Sreenivasan, Sasidharan QH1 Natural history (General - Including nature conservation, geographical distribution) R735-854 Medical education. Medical schools. Research Despite Euphorbia hirta L. ethnomedicinal benefits, very few studies have described the potential toxicity.The aim of the present study was to evaluate the in vivo toxicity of methanolic extracts of E. hirta.The acute and subchronic oral toxicity of E. hirta was evaluated in Sprague Dawley rats. The extract at a single dose of 5000mg/kg did not produce treatment related signs of toxicity or mortality in any of the animals tested during the 14-day observation period. Therefore, the LD 50 of this plant was estimated to be more than 5000mg/kg. In the repeated dose 90-day oral toxicity study, the administration of 50mg/kg, 250mg/kg, and 1000mg/kg/day of E. hirta extract per body weight revealed no significant difference ( Hindawi Publishing Corporation 2013 Article PeerReviewed application/pdf en http://eprints.usm.my/38244/1/Acute_and_Subchronic_Toxicity_Study_of_Euphorbia_hirta_L._Methanol_Extract_in_Rats.pdf Kwan, Yuet Ping and Ibrahim, Darah and Yeng, Chen and Subramaniam, Sreeramanan and Sreenivasan, Sasidharan (2013) Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats. BioMed Research International, 2013 (182064). pp. 1-14. ISSN 2314-6133 http://dx.doi.org/10.1155/2013/182064 |
| spellingShingle | QH1 Natural history (General - Including nature conservation, geographical distribution) R735-854 Medical education. Medical schools. Research Kwan, Yuet Ping Ibrahim, Darah Yeng, Chen Subramaniam, Sreeramanan Sreenivasan, Sasidharan Acute and Subchronic Toxicity Study of Euphorbia hirta L. Methanol Extract in Rats |
| title | Acute and Subchronic Toxicity Study of Euphorbia hirta
L. Methanol Extract in Rats |
| title_full | Acute and Subchronic Toxicity Study of Euphorbia hirta
L. Methanol Extract in Rats |
| title_fullStr | Acute and Subchronic Toxicity Study of Euphorbia hirta
L. Methanol Extract in Rats |
| title_full_unstemmed | Acute and Subchronic Toxicity Study of Euphorbia hirta
L. Methanol Extract in Rats |
| title_short | Acute and Subchronic Toxicity Study of Euphorbia hirta
L. Methanol Extract in Rats |
| title_sort | acute and subchronic toxicity study of euphorbia hirta
l. methanol extract in rats |
| topic | QH1 Natural history (General - Including nature conservation, geographical distribution) R735-854 Medical education. Medical schools. Research |
| url | http://eprints.usm.my/38244/ http://eprints.usm.my/38244/ http://eprints.usm.my/38244/1/Acute_and_Subchronic_Toxicity_Study_of_Euphorbia_hirta_L._Methanol_Extract_in_Rats.pdf |