A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines
A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against ace...
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| Format: | Article |
| Language: | English |
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MDPI
2015
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| Online Access: | http://eprints.usm.my/38014/ http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf |
| _version_ | 1848878348185370624 |
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| author | I. Almansour, Abdulrahman Kumar, Raju Suresh Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf Farooq, Mehvish Murugaiyah, Vikneswaran |
| author_facet | I. Almansour, Abdulrahman Kumar, Raju Suresh Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf Farooq, Mehvish Murugaiyah, Vikneswaran |
| author_sort | I. Almansour, Abdulrahman |
| building | USM Institutional Repository |
| collection | Online Access |
| description | A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities
towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against acethylcholinesterase (AChE).
Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor. |
| first_indexed | 2025-11-15T17:29:54Z |
| format | Article |
| id | usm-38014 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:29:54Z |
| publishDate | 2015 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-380142017-12-20T04:34:10Z http://eprints.usm.my/38014/ A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines I. Almansour, Abdulrahman Kumar, Raju Suresh Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf Farooq, Mehvish Murugaiyah, Vikneswaran QD1-999 Chemistry R735-854 Medical education. Medical schools. Research RS1-441 Pharmacy and materia medica A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 μM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor. MDPI 2015-01 Article PeerReviewed application/pdf en http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf I. Almansour, Abdulrahman and Kumar, Raju Suresh and Arumugam, Natarajan and Basiri, Alireza and Kia, Yalda and Ali, Mohamed Ashraf and Farooq, Mehvish and Murugaiyah, Vikneswaran (2015) A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines. Molecules, 20 (2). pp. 2296-2309. ISSN 1420-3049 https://doi.org/10.3390/molecules20022296 |
| spellingShingle | QD1-999 Chemistry R735-854 Medical education. Medical schools. Research RS1-441 Pharmacy and materia medica I. Almansour, Abdulrahman Kumar, Raju Suresh Arumugam, Natarajan Basiri, Alireza Kia, Yalda Ali, Mohamed Ashraf Farooq, Mehvish Murugaiyah, Vikneswaran A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines |
| title | A Facile Ionic Liquid Promoted Synthesis, Cholinesterase
Inhibitory Activity and Molecular Modeling Study of Novel
Highly Functionalized Spiropyrrolidines |
| title_full | A Facile Ionic Liquid Promoted Synthesis, Cholinesterase
Inhibitory Activity and Molecular Modeling Study of Novel
Highly Functionalized Spiropyrrolidines |
| title_fullStr | A Facile Ionic Liquid Promoted Synthesis, Cholinesterase
Inhibitory Activity and Molecular Modeling Study of Novel
Highly Functionalized Spiropyrrolidines |
| title_full_unstemmed | A Facile Ionic Liquid Promoted Synthesis, Cholinesterase
Inhibitory Activity and Molecular Modeling Study of Novel
Highly Functionalized Spiropyrrolidines |
| title_short | A Facile Ionic Liquid Promoted Synthesis, Cholinesterase
Inhibitory Activity and Molecular Modeling Study of Novel
Highly Functionalized Spiropyrrolidines |
| title_sort | facile ionic liquid promoted synthesis, cholinesterase
inhibitory activity and molecular modeling study of novel
highly functionalized spiropyrrolidines |
| topic | QD1-999 Chemistry R735-854 Medical education. Medical schools. Research RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/38014/ http://eprints.usm.my/38014/ http://eprints.usm.my/38014/1/A_Facile_Ionic_Liquid_Promoted_Synthesis%2C_Cholinesterase_Inhibitory.pdf |