3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors
Dengue is a severe mosquito-borne viral in fection causing half a million deaths annually. Dengue virusNS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues 4a–4j were synthesized and screened in silico against...
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Elsevier
2017
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| Online Access: | http://eprints.usm.my/37959/ |
| _version_ | 1848878334054760448 |
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| author | Osman, Hasnah Idris, Nor Hashima Kamarulzaman, Ezatul Ezleen A. Wahab, Habibah Hassan, Mohd. Zaheen |
| author_facet | Osman, Hasnah Idris, Nor Hashima Kamarulzaman, Ezatul Ezleen A. Wahab, Habibah Hassan, Mohd. Zaheen |
| author_sort | Osman, Hasnah |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Dengue is a severe mosquito-borne viral in fection causing half a million deaths annually. Dengue virusNS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues 4a–4j were synthesized and screened in silico against DENV2 NS2B/NS3 protease to elucidate their binding mechanism and orientation around the
active sites. Results were validated through an in vitro DENV2 NS2B/NS3 protease assay using a fluorogenic Boc-Gly-Arg-Arg-AMC substrate. Nitro derivatives of 3,5-is(arylidene)-4-piperidones(4e and 4j) merged as promising lead molecules for novel protease inhibitors with an IC50 of 15.22 and 16.23 umoI/L, respectively, compared to the standard, panduratin A, having IC50 of 57.28 umoI/L. |
| first_indexed | 2025-11-15T17:29:41Z |
| format | Article |
| id | usm-37959 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T17:29:41Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-379592017-12-19T01:58:00Z http://eprints.usm.my/37959/ 3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors Osman, Hasnah Idris, Nor Hashima Kamarulzaman, Ezatul Ezleen A. Wahab, Habibah Hassan, Mohd. Zaheen QD1-999 Chemistry RS1-441 Pharmacy and materia medica Dengue is a severe mosquito-borne viral in fection causing half a million deaths annually. Dengue virusNS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues 4a–4j were synthesized and screened in silico against DENV2 NS2B/NS3 protease to elucidate their binding mechanism and orientation around the active sites. Results were validated through an in vitro DENV2 NS2B/NS3 protease assay using a fluorogenic Boc-Gly-Arg-Arg-AMC substrate. Nitro derivatives of 3,5-is(arylidene)-4-piperidones(4e and 4j) merged as promising lead molecules for novel protease inhibitors with an IC50 of 15.22 and 16.23 umoI/L, respectively, compared to the standard, panduratin A, having IC50 of 57.28 umoI/L. Elsevier 2017-07 Article PeerReviewed Osman, Hasnah and Idris, Nor Hashima and Kamarulzaman, Ezatul Ezleen and A. Wahab, Habibah and Hassan, Mohd. Zaheen (2017) 3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors. Acta Pharmaceutica Sinica B, 7 (4). pp. 479-484. ISSN 2211-3835 http://dx.doi.org/10.1016/j.apsb.2017.04.009 |
| spellingShingle | QD1-999 Chemistry RS1-441 Pharmacy and materia medica Osman, Hasnah Idris, Nor Hashima Kamarulzaman, Ezatul Ezleen A. Wahab, Habibah Hassan, Mohd. Zaheen 3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors |
| title | 3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors |
| title_full | 3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors |
| title_fullStr | 3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors |
| title_full_unstemmed | 3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors |
| title_short | 3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors |
| title_sort | 3,5-bis(arylidene)-4-piperidones as potential dengue protease inhibitors |
| topic | QD1-999 Chemistry RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/37959/ http://eprints.usm.my/37959/ |