Effect of Vitamin E on Human Periodontal Ligament Fibroblasts
The periodontal ligament fibroblasts plays an essential role in the organization and maintenance of the connective tissue during development and in response to injuries and diseases. They are also responsible of the migration and differentiation of the variety of cells that takes part in the osteo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing
2016
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| Subjects: | |
| Online Access: | http://eprints.usm.my/37932/ http://eprints.usm.my/37932/1/1.4968874.pdf |
| Summary: | The periodontal ligament fibroblasts plays an essential role in the organization and maintenance of the
connective tissue during development and in response to injuries and diseases. They are also responsible of
the migration and differentiation of the variety of cells that takes part in the osteogenesis in response to
external forces (1, 2). Age related changes include decreased fibroblasts density and cellular activity which
slows orthodontic tooth movement due to prolonged response of the connective tissue to external forces
which poses a potential risk in orthodontic treatment (3, 4).
Vitamin E had been studied worldwide due to its health benefits in the fields of chronic diseases and
ageing such as the anti-inflammatory and anti-osteoporotic effects (5, 6). Vitamin E consists of 2 major
isoforms: tocopherols and tocotrienols, each with four distinct analogues (alpha, beta, gamma, and delta).
Tocopherols are saturated forms of vitamin E, and tocotrienols are the unsaturated forms, distinguishable by
the three double bonds in the tails of tocotrienols (7). Studies showed that tocotrienol is superior for its
antioxidant properties as well as increasing cells viability and proliferation (8, 9). The current project aim to
evaluate the response of human periodontal ligament fibroblasts (HPdLF) upon exposure to various
concentrations of tocotrienols rich fraction (TRF) conditioned medium. |
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