Quantification of Dynamic 11C-Phenytoin PET Studies
The overexpression of P-glycoprotein (Pgp) is thought to be an important mechanism of pharmacoresistance in epilepsy. Recently, 11C-phenytoin has been evaluated preclinically as a tracer for Pgp. The aim of the present study was to assess the optimal plasma kinetic model for quantification of 11...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Society of Nuclear Medicine
2015
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| Subjects: | |
| Online Access: | http://eprints.usm.my/37523/ http://eprints.usm.my/37523/1/syahirnuclmedpostprint.pdf |
| _version_ | 1848878216314355712 |
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| author | Mansor, Mohd Syahir Boellaard, Ronald Froklage, Femke E. Bakker, Esther D.M. Yaqub, Maqsood Voskuyl, Rob A. Schwarte, Lothar A. Verbeek, Joost Windhorst, Albert D. Lammertsma, Adriaan |
| author_facet | Mansor, Mohd Syahir Boellaard, Ronald Froklage, Femke E. Bakker, Esther D.M. Yaqub, Maqsood Voskuyl, Rob A. Schwarte, Lothar A. Verbeek, Joost Windhorst, Albert D. Lammertsma, Adriaan |
| author_sort | Mansor, Mohd Syahir |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The overexpression of P-glycoprotein (Pgp) is thought to be an
important mechanism of pharmacoresistance in epilepsy. Recently,
11C-phenytoin has been evaluated preclinically as a tracer for Pgp.
The aim of the present study was to assess the optimal plasma
kinetic model for quantification of 11C-phenytoin studies in humans.
Methods: Dynamic 11C-phenytoin PET scans of 6 healthy volunteers
with arterial sampling were acquired twice on the same day
and analyzed using single- and 2-tissue-compartment models with
and without a blood volume parameter. Global and regional test–
retest (TRT) variability was determined for both plasma to tissue rate
constant (K1) and volume of distribution (VT). Results: According to the
Akaike information criterion, the reversible single-tissue-compartment
model with blood volume parameter was the preferred plasma input
model. Mean TRT variability ranged from 1.5% to 16.9% for K1 and
from 0.5% to 5.8% for VT. Larger volumes of interest showed better
repeatabilities than smaller regions. A 45-min scan provided essentially
the same K1 and VT values as a 60-min scan. Conclusion: A reversible
single-tissue-compartment model with blood volume seems to be a
good candidate model for quantification of dynamic 11C-phenytoin
studies. Scan duration may be reduced to 45 min without notable
loss of accuracy and precision of both K1 and VT, although this still
needs to be confirmed under pathologic conditions. |
| first_indexed | 2025-11-15T17:27:48Z |
| format | Article |
| id | usm-37523 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:27:48Z |
| publishDate | 2015 |
| publisher | Society of Nuclear Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-375232017-11-20T03:20:16Z http://eprints.usm.my/37523/ Quantification of Dynamic 11C-Phenytoin PET Studies Mansor, Mohd Syahir Boellaard, Ronald Froklage, Femke E. Bakker, Esther D.M. Yaqub, Maqsood Voskuyl, Rob A. Schwarte, Lothar A. Verbeek, Joost Windhorst, Albert D. Lammertsma, Adriaan RM300-666 Drugs and their actions The overexpression of P-glycoprotein (Pgp) is thought to be an important mechanism of pharmacoresistance in epilepsy. Recently, 11C-phenytoin has been evaluated preclinically as a tracer for Pgp. The aim of the present study was to assess the optimal plasma kinetic model for quantification of 11C-phenytoin studies in humans. Methods: Dynamic 11C-phenytoin PET scans of 6 healthy volunteers with arterial sampling were acquired twice on the same day and analyzed using single- and 2-tissue-compartment models with and without a blood volume parameter. Global and regional test– retest (TRT) variability was determined for both plasma to tissue rate constant (K1) and volume of distribution (VT). Results: According to the Akaike information criterion, the reversible single-tissue-compartment model with blood volume parameter was the preferred plasma input model. Mean TRT variability ranged from 1.5% to 16.9% for K1 and from 0.5% to 5.8% for VT. Larger volumes of interest showed better repeatabilities than smaller regions. A 45-min scan provided essentially the same K1 and VT values as a 60-min scan. Conclusion: A reversible single-tissue-compartment model with blood volume seems to be a good candidate model for quantification of dynamic 11C-phenytoin studies. Scan duration may be reduced to 45 min without notable loss of accuracy and precision of both K1 and VT, although this still needs to be confirmed under pathologic conditions. Society of Nuclear Medicine 2015-09 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/37523/1/syahirnuclmedpostprint.pdf Mansor, Mohd Syahir and Boellaard, Ronald and Froklage, Femke E. and Bakker, Esther D.M. and Yaqub, Maqsood and Voskuyl, Rob A. and Schwarte, Lothar A. and Verbeek, Joost and Windhorst, Albert D. and Lammertsma, Adriaan (2015) Quantification of Dynamic 11C-Phenytoin PET Studies. Journal of Nuclear Medicine, 56 (9). pp. 1327-1377. ISSN 0161-5505 http://jnm.snmjournals.org/content/56/9/1372.short |
| spellingShingle | RM300-666 Drugs and their actions Mansor, Mohd Syahir Boellaard, Ronald Froklage, Femke E. Bakker, Esther D.M. Yaqub, Maqsood Voskuyl, Rob A. Schwarte, Lothar A. Verbeek, Joost Windhorst, Albert D. Lammertsma, Adriaan Quantification of Dynamic 11C-Phenytoin PET Studies |
| title | Quantification of Dynamic 11C-Phenytoin PET Studies |
| title_full | Quantification of Dynamic 11C-Phenytoin PET Studies |
| title_fullStr | Quantification of Dynamic 11C-Phenytoin PET Studies |
| title_full_unstemmed | Quantification of Dynamic 11C-Phenytoin PET Studies |
| title_short | Quantification of Dynamic 11C-Phenytoin PET Studies |
| title_sort | quantification of dynamic 11c-phenytoin pet studies |
| topic | RM300-666 Drugs and their actions |
| url | http://eprints.usm.my/37523/ http://eprints.usm.my/37523/ http://eprints.usm.my/37523/1/syahirnuclmedpostprint.pdf |