Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report
This case report describes a complex radical 3D-Conformal Radiotherapy treatment planning, dosimetric issues and outcome of definitive treatment of un-resectable carcinoma of the vulvar in a 42-year old lady. The patient presented with large fungating mass of the vulva which was biopsy confirmed...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IOP Publishing
2017
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| Online Access: | http://eprints.usm.my/37330/ http://eprints.usm.my/37330/1/Kumar_2017_J_Phys_012041.pdf |
| _version_ | 1848878163745046528 |
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| author | Appalanaido, Gokula Kumar I, Norhafizah I, Shazril AR, Nursyatina MZ, Abdul Aziz Mohd Zin, Mohd Hafiz MK, Zakir J, Norjayadi AS, Norliza A, Ismail N, Khairun |
| author_facet | Appalanaido, Gokula Kumar I, Norhafizah I, Shazril AR, Nursyatina MZ, Abdul Aziz Mohd Zin, Mohd Hafiz MK, Zakir J, Norjayadi AS, Norliza A, Ismail N, Khairun |
| author_sort | Appalanaido, Gokula Kumar |
| building | USM Institutional Repository |
| collection | Online Access |
| description | This case report describes a complex radical 3D-Conformal Radiotherapy treatment
planning, dosimetric issues and outcome of definitive treatment of un-resectable carcinoma of
the vulvar in a 42-year old lady. The patient presented with large fungating mass of the vulva
which was biopsy confirmed as Keratinizing Squamous Cell Carcinoma. Further staging
investigation revealed locally advanced disease (T4), with bilateral inguinal lymph nodes
involvement. There is no systemic metastasis or intra-pelvic nodes. The patient was seen by
Gynae-Oncology team and the disease was deemed un-resectable without significant morbidity.
She was treated to a total dose of 64.8Gy in 36 fractions over 7 weeks with concurrent weekly
Cisplatinum in 2 phases. 3D-Conformal radiotherapy technique using the modified segmental
boost technique (MSBT, large PA and small AP photon fields with inguinal electron matching)
was used. TLD chips were used for in-vivo dose verification in phase 1 and 2 of the treatment.
At completion of planned radiotherapy, patient had a complete clinical response, grade 2-3 skin
toxicity, grade 2 rectal toxicity, and grade 2 dysuria Vulval Squamous Cell Carcinomas are very
radiosensitive tumours and the skills of the treating Radiation Oncologist, Dosimetrists,
Physicist, Radiation Therapist and also nurses is of foremost importance is ensuring good clinical
outcomes. |
| first_indexed | 2025-11-15T17:26:58Z |
| format | Article |
| id | usm-37330 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:26:58Z |
| publishDate | 2017 |
| publisher | IOP Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-373302017-11-20T02:31:14Z http://eprints.usm.my/37330/ Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report Appalanaido, Gokula Kumar I, Norhafizah I, Shazril AR, Nursyatina MZ, Abdul Aziz Mohd Zin, Mohd Hafiz MK, Zakir J, Norjayadi AS, Norliza A, Ismail N, Khairun RL Dermatology This case report describes a complex radical 3D-Conformal Radiotherapy treatment planning, dosimetric issues and outcome of definitive treatment of un-resectable carcinoma of the vulvar in a 42-year old lady. The patient presented with large fungating mass of the vulva which was biopsy confirmed as Keratinizing Squamous Cell Carcinoma. Further staging investigation revealed locally advanced disease (T4), with bilateral inguinal lymph nodes involvement. There is no systemic metastasis or intra-pelvic nodes. The patient was seen by Gynae-Oncology team and the disease was deemed un-resectable without significant morbidity. She was treated to a total dose of 64.8Gy in 36 fractions over 7 weeks with concurrent weekly Cisplatinum in 2 phases. 3D-Conformal radiotherapy technique using the modified segmental boost technique (MSBT, large PA and small AP photon fields with inguinal electron matching) was used. TLD chips were used for in-vivo dose verification in phase 1 and 2 of the treatment. At completion of planned radiotherapy, patient had a complete clinical response, grade 2-3 skin toxicity, grade 2 rectal toxicity, and grade 2 dysuria Vulval Squamous Cell Carcinomas are very radiosensitive tumours and the skills of the treating Radiation Oncologist, Dosimetrists, Physicist, Radiation Therapist and also nurses is of foremost importance is ensuring good clinical outcomes. IOP Publishing 2017 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/37330/1/Kumar_2017_J_Phys_012041.pdf Appalanaido, Gokula Kumar and I, Norhafizah and I, Shazril and AR, Nursyatina and MZ, Abdul Aziz and Mohd Zin, Mohd Hafiz and MK, Zakir and J, Norjayadi and AS, Norliza and A, Ismail and N, Khairun (2017) Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report. Journal of Physics: Conference Series, 851 (1). pp. 1-6. ISSN 1742-6588 https://doi.org/10.1088/1742-6596/851/1/012041 |
| spellingShingle | RL Dermatology Appalanaido, Gokula Kumar I, Norhafizah I, Shazril AR, Nursyatina MZ, Abdul Aziz Mohd Zin, Mohd Hafiz MK, Zakir J, Norjayadi AS, Norliza A, Ismail N, Khairun Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report |
| title | Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report |
| title_full | Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report |
| title_fullStr | Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report |
| title_full_unstemmed | Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report |
| title_short | Definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report |
| title_sort | definitive radiotherapy for locally advanced squamous cell carcinoma of the vulva and technical issues: a case report |
| topic | RL Dermatology |
| url | http://eprints.usm.my/37330/ http://eprints.usm.my/37330/ http://eprints.usm.my/37330/1/Kumar_2017_J_Phys_012041.pdf |