Inhibitory Effects of Tualang Honey on Experimental Breast Cancer in Rats: A Preliminary Study
The study was conducted to determine the effect of Malaysian jungle Tualang Honey (TH) on development of breast cancer induced by the carcinogen 7,12-dimethylbenz(α)anthracene (DMBA) in rats. Forty nulliparous female Sprague-Dawley rats were given 80 mg/kg DMBA then randomly divided into four grou...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Asian Pacific Organization for Cancer Prevetion
2013
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| Subjects: | |
| Online Access: | http://eprints.usm.my/37322/ http://eprints.usm.my/37322/1/POCPA9_2013_v14n4_2249.pdf |
| _version_ | 1848878161410916352 |
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| author | Abd Kadir, Erazuliana Sulaiman, Siti Amrah Yahya, Nurul Khaiza Othman, Nor Hayati |
| author_facet | Abd Kadir, Erazuliana Sulaiman, Siti Amrah Yahya, Nurul Khaiza Othman, Nor Hayati |
| author_sort | Abd Kadir, Erazuliana |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The study was conducted to determine the effect of Malaysian jungle Tualang Honey (TH) on development
of breast cancer induced by the carcinogen 7,12-dimethylbenz(α)anthracene (DMBA) in rats. Forty nulliparous
female Sprague-Dawley rats were given 80 mg/kg DMBA then randomly divided into four groups: Group 1
served as a Control while Groups 2, 3 and 4 received 0.2, 1.0 or 2.0 g/kg bodyweight/day of TH, respectively, for
150 days. Results showed that breast cancers in the TH-treated groups had slower size increment and smaller
mean tumor size (≤2cm3
) compared to Controls (≤8cm3
). The number of cancers developing in TH-treated groups
was also significantly fewer (P<0.05). Histological grading showed majority of TH–treated group cancers to be
of grade 1 and 2 compared to grade 3 in controls. There was an increasing trend of apoptotic index (AI) seen
in TH-treated groups with increasing dosage of Tualang Honey, however, the mean AI values of all TH-treated
groups were not significantly different from the Control value (p>0.05). In conclusion, Tualang Honey exerted
positive modulation effects on DMBA-induced breast cancers in rats in this preliminary study |
| first_indexed | 2025-11-15T17:26:56Z |
| format | Article |
| id | usm-37322 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:26:56Z |
| publishDate | 2013 |
| publisher | Asian Pacific Organization for Cancer Prevetion |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-373222017-11-02T09:40:17Z http://eprints.usm.my/37322/ Inhibitory Effects of Tualang Honey on Experimental Breast Cancer in Rats: A Preliminary Study Abd Kadir, Erazuliana Sulaiman, Siti Amrah Yahya, Nurul Khaiza Othman, Nor Hayati RJ370-550 Diseases of children and adolescents The study was conducted to determine the effect of Malaysian jungle Tualang Honey (TH) on development of breast cancer induced by the carcinogen 7,12-dimethylbenz(α)anthracene (DMBA) in rats. Forty nulliparous female Sprague-Dawley rats were given 80 mg/kg DMBA then randomly divided into four groups: Group 1 served as a Control while Groups 2, 3 and 4 received 0.2, 1.0 or 2.0 g/kg bodyweight/day of TH, respectively, for 150 days. Results showed that breast cancers in the TH-treated groups had slower size increment and smaller mean tumor size (≤2cm3 ) compared to Controls (≤8cm3 ). The number of cancers developing in TH-treated groups was also significantly fewer (P<0.05). Histological grading showed majority of TH–treated group cancers to be of grade 1 and 2 compared to grade 3 in controls. There was an increasing trend of apoptotic index (AI) seen in TH-treated groups with increasing dosage of Tualang Honey, however, the mean AI values of all TH-treated groups were not significantly different from the Control value (p>0.05). In conclusion, Tualang Honey exerted positive modulation effects on DMBA-induced breast cancers in rats in this preliminary study Asian Pacific Organization for Cancer Prevetion 2013 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/37322/1/POCPA9_2013_v14n4_2249.pdf Abd Kadir, Erazuliana and Sulaiman, Siti Amrah and Yahya, Nurul Khaiza and Othman, Nor Hayati (2013) Inhibitory Effects of Tualang Honey on Experimental Breast Cancer in Rats: A Preliminary Study. Asian Pacific Journal of Cancer Prevention, 14 (4). pp. 2249-2254. ISSN 1513-7368 http://www.koreascience.or.kr/article/ArticleFullRecord.jsp?cn=POCPA9_2013_v14n4_2249 |
| spellingShingle | RJ370-550 Diseases of children and adolescents Abd Kadir, Erazuliana Sulaiman, Siti Amrah Yahya, Nurul Khaiza Othman, Nor Hayati Inhibitory Effects of Tualang Honey on Experimental Breast Cancer in Rats: A Preliminary Study |
| title | Inhibitory Effects of Tualang Honey on Experimental Breast
Cancer in Rats: A Preliminary Study |
| title_full | Inhibitory Effects of Tualang Honey on Experimental Breast
Cancer in Rats: A Preliminary Study |
| title_fullStr | Inhibitory Effects of Tualang Honey on Experimental Breast
Cancer in Rats: A Preliminary Study |
| title_full_unstemmed | Inhibitory Effects of Tualang Honey on Experimental Breast
Cancer in Rats: A Preliminary Study |
| title_short | Inhibitory Effects of Tualang Honey on Experimental Breast
Cancer in Rats: A Preliminary Study |
| title_sort | inhibitory effects of tualang honey on experimental breast
cancer in rats: a preliminary study |
| topic | RJ370-550 Diseases of children and adolescents |
| url | http://eprints.usm.my/37322/ http://eprints.usm.my/37322/ http://eprints.usm.my/37322/1/POCPA9_2013_v14n4_2249.pdf |