Visual electrophy siological tests in obstructive sleep apnoea
AIM:To compare the pattern electroretinogram (PERG) and pattern visual evoked potential ( PVEP ) between obstructive sleep apnoea (OSA) patients and controls. METHODS: This was a prospective cross - sectional study involving 40 OSA patients and 31 control subjects in Hospital Universiti Sains Ma...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology
2017
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| Online Access: | http://eprints.usm.my/37282/ http://eprints.usm.my/37282/1/%28Visual_electrophy%29_201707005.pdf |
| _version_ | 1848878150400868352 |
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| author | Seok, Hui Ng Tai, Evelyn Li Min Abdullah, Baharudin Mohd Noor, Raja Azmi Wan Hitam, Wan-Hazabbah |
| author_facet | Seok, Hui Ng Tai, Evelyn Li Min Abdullah, Baharudin Mohd Noor, Raja Azmi Wan Hitam, Wan-Hazabbah |
| author_sort | Seok, Hui Ng |
| building | USM Institutional Repository |
| collection | Online Access |
| description | AIM:To compare the pattern electroretinogram (PERG) and pattern visual evoked potential ( PVEP ) between
obstructive sleep apnoea (OSA) patients and controls.
METHODS: This was a prospective cross - sectional
study involving 40 OSA patients and 31 control subjects in
Hospital Universiti Sains Malaysia. Patients with a
confirmed diagnosis of OSA who had no ocular pathology
were randomly selected to participate in the study. The
apnoea-hypopnoea index (AHI) was obtained from their
records and used for stratification of OSA severity.
Electrophysiological tests ( PVEP and PERG ) were
performed on each patient by a trained technician in the
electrophysiology laboratory of the Department of
Ophthalmology, USM. The results obtained were
recorded as median values. Data analysis was done using
IBM Statistics Version 21. 0.
RESULTS: Among OSA patients, we observed a
significant reduction of the PERG amplitude P50 ( P <
0.001) and the PVEP amplitude P100 (P<0. 001) compared
to the control group. OSA patients also had a significant
increase in PVEP time to peak P100 (P = 0. 003) and time to
peak N75 (P = 0. 004). However, no significant differences
were detected in PERG time to peak between OSA
patients and controls. There were likewise no significant
differences in PVEP or PERG between OSA patients with
different disease severity.
CONCLUSION: OSA patients have significant
abnormalities in PVEP amplitude and time to peak, as
well as PERG amplitude. This may reflect subclinical optic
nerve dysfunction in OSA. Further research is needed to
determine the association between the severity of OSA
and the degree of optic nerve dysfunction. |
| first_indexed | 2025-11-15T17:26:46Z |
| format | Article |
| id | usm-37282 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:26:46Z |
| publishDate | 2017 |
| publisher | Press of International Journal of Ophthalmology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-372822017-10-31T03:20:07Z http://eprints.usm.my/37282/ Visual electrophy siological tests in obstructive sleep apnoea Seok, Hui Ng Tai, Evelyn Li Min Abdullah, Baharudin Mohd Noor, Raja Azmi Wan Hitam, Wan-Hazabbah RE Ophthalmology RF Otorhinolaryngology AIM:To compare the pattern electroretinogram (PERG) and pattern visual evoked potential ( PVEP ) between obstructive sleep apnoea (OSA) patients and controls. METHODS: This was a prospective cross - sectional study involving 40 OSA patients and 31 control subjects in Hospital Universiti Sains Malaysia. Patients with a confirmed diagnosis of OSA who had no ocular pathology were randomly selected to participate in the study. The apnoea-hypopnoea index (AHI) was obtained from their records and used for stratification of OSA severity. Electrophysiological tests ( PVEP and PERG ) were performed on each patient by a trained technician in the electrophysiology laboratory of the Department of Ophthalmology, USM. The results obtained were recorded as median values. Data analysis was done using IBM Statistics Version 21. 0. RESULTS: Among OSA patients, we observed a significant reduction of the PERG amplitude P50 ( P < 0.001) and the PVEP amplitude P100 (P<0. 001) compared to the control group. OSA patients also had a significant increase in PVEP time to peak P100 (P = 0. 003) and time to peak N75 (P = 0. 004). However, no significant differences were detected in PERG time to peak between OSA patients and controls. There were likewise no significant differences in PVEP or PERG between OSA patients with different disease severity. CONCLUSION: OSA patients have significant abnormalities in PVEP amplitude and time to peak, as well as PERG amplitude. This may reflect subclinical optic nerve dysfunction in OSA. Further research is needed to determine the association between the severity of OSA and the degree of optic nerve dysfunction. Press of International Journal of Ophthalmology 2017-07 Article PeerReviewed application/pdf en http://eprints.usm.my/37282/1/%28Visual_electrophy%29_201707005.pdf Seok, Hui Ng and Tai, Evelyn Li Min and Abdullah, Baharudin and Mohd Noor, Raja Azmi and Wan Hitam, Wan-Hazabbah (2017) Visual electrophy siological tests in obstructive sleep apnoea. International Eye Science (Guoji Yanke Zazhi), 17 (7). pp. 1215-1220. ISSN 1672-5123 http://ies.ijo.cn/cn_publish/2017/7/201707005.pdf |
| spellingShingle | RE Ophthalmology RF Otorhinolaryngology Seok, Hui Ng Tai, Evelyn Li Min Abdullah, Baharudin Mohd Noor, Raja Azmi Wan Hitam, Wan-Hazabbah Visual electrophy siological tests in obstructive sleep apnoea |
| title | Visual electrophy siological tests in obstructive sleep apnoea |
| title_full | Visual electrophy siological tests in obstructive sleep apnoea |
| title_fullStr | Visual electrophy siological tests in obstructive sleep apnoea |
| title_full_unstemmed | Visual electrophy siological tests in obstructive sleep apnoea |
| title_short | Visual electrophy siological tests in obstructive sleep apnoea |
| title_sort | visual electrophy siological tests in obstructive sleep apnoea |
| topic | RE Ophthalmology RF Otorhinolaryngology |
| url | http://eprints.usm.my/37282/ http://eprints.usm.my/37282/ http://eprints.usm.my/37282/1/%28Visual_electrophy%29_201707005.pdf |