Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure
Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stressmediated cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats. The rats were orall...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2017
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| Online Access: | http://eprints.usm.my/37275/ http://eprints.usm.my/37275/1/%28Tualang_Honey_Protects_the_Rat%29_4605782.pdf |
| _version_ | 1848878148583686144 |
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| author | Suk, Peng Tang Nainamohamed Salam, Sirajudeen Kuttulebbai Jaafar, Hasnan Siew, Hua Gan Muzaimi, Mustapha Sulaiman, Siti Amrah |
| author_facet | Suk, Peng Tang Nainamohamed Salam, Sirajudeen Kuttulebbai Jaafar, Hasnan Siew, Hua Gan Muzaimi, Mustapha Sulaiman, Siti Amrah |
| author_sort | Suk, Peng Tang |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stressmediated
cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the
midbrain and lungs of rats. The rats were orally treated with distilled water (2mL/kg/day), Tualang honey (1.0 g/kg/day), or
ubiquinol (0.2 g/kg/day) throughout the experimental period. Two weeks after the respective treatments, the rats were injected
intraperitoneally with saline (1 mL/kg/week) or PQ (10mg/kg/week) once per week for four consecutive weeks. After four weekly
exposures to PQ, the glutathione peroxidase activity and the number of tyrosine-hydroxylase immunopositive neurons in the
midbrain were significantly decreased in animals from group PQ ( |
| first_indexed | 2025-11-15T17:26:44Z |
| format | Article |
| id | usm-37275 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:26:44Z |
| publishDate | 2017 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-372752017-10-30T09:51:30Z http://eprints.usm.my/37275/ Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure Suk, Peng Tang Nainamohamed Salam, Sirajudeen Kuttulebbai Jaafar, Hasnan Siew, Hua Gan Muzaimi, Mustapha Sulaiman, Siti Amrah RB Pathology RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM Therapeutics. Pharmacology Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stressmediated cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats. The rats were orally treated with distilled water (2mL/kg/day), Tualang honey (1.0 g/kg/day), or ubiquinol (0.2 g/kg/day) throughout the experimental period. Two weeks after the respective treatments, the rats were injected intraperitoneally with saline (1 mL/kg/week) or PQ (10mg/kg/week) once per week for four consecutive weeks. After four weekly exposures to PQ, the glutathione peroxidase activity and the number of tyrosine-hydroxylase immunopositive neurons in the midbrain were significantly decreased in animals from group PQ ( Hindawi Publishing Corporation 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/37275/1/%28Tualang_Honey_Protects_the_Rat%29_4605782.pdf Suk, Peng Tang and Nainamohamed Salam, Sirajudeen Kuttulebbai and Jaafar, Hasnan and Siew, Hua Gan and Muzaimi, Mustapha and Sulaiman, Siti Amrah (2017) Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure. Oxidative Medicine and Cellular Longevity, 2017 (460578). pp. 1-12. ISSN 1942-0900 https://doi.org/10.1155/2017/4605782 |
| spellingShingle | RB Pathology RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM Therapeutics. Pharmacology Suk, Peng Tang Nainamohamed Salam, Sirajudeen Kuttulebbai Jaafar, Hasnan Siew, Hua Gan Muzaimi, Mustapha Sulaiman, Siti Amrah Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure |
| title | Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure |
| title_full | Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure |
| title_fullStr | Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure |
| title_full_unstemmed | Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure |
| title_short | Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure |
| title_sort | tualang honey protects the rat midbrain and lung against repeated paraquat exposure |
| topic | RB Pathology RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry RM Therapeutics. Pharmacology |
| url | http://eprints.usm.my/37275/ http://eprints.usm.my/37275/ http://eprints.usm.my/37275/1/%28Tualang_Honey_Protects_the_Rat%29_4605782.pdf |