Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure
Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stressmediated cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats. The rats were orall...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Publishing Corporation
2017
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| Subjects: | |
| Online Access: | http://eprints.usm.my/37275/ http://eprints.usm.my/37275/1/%28Tualang_Honey_Protects_the_Rat%29_4605782.pdf |
| Summary: | Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stressmediated
cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the
midbrain and lungs of rats. The rats were orally treated with distilled water (2mL/kg/day), Tualang honey (1.0 g/kg/day), or
ubiquinol (0.2 g/kg/day) throughout the experimental period. Two weeks after the respective treatments, the rats were injected
intraperitoneally with saline (1 mL/kg/week) or PQ (10mg/kg/week) once per week for four consecutive weeks. After four weekly
exposures to PQ, the glutathione peroxidase activity and the number of tyrosine-hydroxylase immunopositive neurons in the
midbrain were significantly decreased in animals from group PQ ( |
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