Targeting Lung Cancer Stem Cells: Research and Clinical Impacts
Lung cancer is the most common cancer worldwide, accounting for 1.8 million new cases and 1.6 million deaths in 2012. Non-small cell lung cancer (NSCLC), which is one of two types of lung cancer, accounts for 85–90% of all lung cancers. Despite advances in therapy, lung cancer still remains a lea...
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| Format: | Article |
| Language: | English |
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Frontiers Media
2017
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| Online Access: | http://eprints.usm.my/37242/ http://eprints.usm.my/37242/1/%28Targeting_Lung_Cancer_Stem%29_fonc-07-00080.pdf |
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| author | Zakaria, Norashikin Satar, Nazilah Abdul Halim, Noor Hanis Abu Ngalim, Siti Hawa Yusoff, Narazah Mohd Lin, Juntang Yahaya, Badrul Hisham |
| author_facet | Zakaria, Norashikin Satar, Nazilah Abdul Halim, Noor Hanis Abu Ngalim, Siti Hawa Yusoff, Narazah Mohd Lin, Juntang Yahaya, Badrul Hisham |
| author_sort | Zakaria, Norashikin |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Lung cancer is the most common cancer worldwide, accounting for 1.8 million new
cases and 1.6 million deaths in 2012. Non-small cell lung cancer (NSCLC), which is one
of two types of lung cancer, accounts for 85–90% of all lung cancers. Despite advances
in therapy, lung cancer still remains a leading cause of death. Cancer relapse and dissemination
after treatment indicates the existence of a niche of cancer cells that are not
fully eradicated by current therapies. These chemoresistant populations of cancer cells
are called cancer stem cells (CSCs) because they possess the self-renewal and differentiation
capabilities similar to those of normal stem cells. Targeting the niche of CSCs in
combination with chemotherapy might provide a promising strategy to eradicate these
cells. Thus, understanding the characteristics of CSCs has become a focus of studies
of NSCLC therapies. |
| first_indexed | 2025-11-15T17:26:34Z |
| format | Article |
| id | usm-37242 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:26:34Z |
| publishDate | 2017 |
| publisher | Frontiers Media |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-372422018-02-12T08:09:59Z http://eprints.usm.my/37242/ Targeting Lung Cancer Stem Cells: Research and Clinical Impacts Zakaria, Norashikin Satar, Nazilah Abdul Halim, Noor Hanis Abu Ngalim, Siti Hawa Yusoff, Narazah Mohd Lin, Juntang Yahaya, Badrul Hisham RK1-715 Dentistry Lung cancer is the most common cancer worldwide, accounting for 1.8 million new cases and 1.6 million deaths in 2012. Non-small cell lung cancer (NSCLC), which is one of two types of lung cancer, accounts for 85–90% of all lung cancers. Despite advances in therapy, lung cancer still remains a leading cause of death. Cancer relapse and dissemination after treatment indicates the existence of a niche of cancer cells that are not fully eradicated by current therapies. These chemoresistant populations of cancer cells are called cancer stem cells (CSCs) because they possess the self-renewal and differentiation capabilities similar to those of normal stem cells. Targeting the niche of CSCs in combination with chemotherapy might provide a promising strategy to eradicate these cells. Thus, understanding the characteristics of CSCs has become a focus of studies of NSCLC therapies. Frontiers Media 2017-05 Article PeerReviewed application/pdf en http://eprints.usm.my/37242/1/%28Targeting_Lung_Cancer_Stem%29_fonc-07-00080.pdf Zakaria, Norashikin and Satar, Nazilah Abdul and Halim, Noor Hanis Abu and Ngalim, Siti Hawa and Yusoff, Narazah Mohd and Lin, Juntang and Yahaya, Badrul Hisham (2017) Targeting Lung Cancer Stem Cells: Research and Clinical Impacts. Frontiers in Oncology, 7 (80). pp. 1-10. ISSN 2234-943X https://doi.org/10.3389/fonc.2017.00080 |
| spellingShingle | RK1-715 Dentistry Zakaria, Norashikin Satar, Nazilah Abdul Halim, Noor Hanis Abu Ngalim, Siti Hawa Yusoff, Narazah Mohd Lin, Juntang Yahaya, Badrul Hisham Targeting Lung Cancer Stem Cells: Research and Clinical Impacts |
| title | Targeting Lung Cancer Stem Cells: Research and Clinical Impacts |
| title_full | Targeting Lung Cancer Stem Cells: Research and Clinical Impacts |
| title_fullStr | Targeting Lung Cancer Stem Cells: Research and Clinical Impacts |
| title_full_unstemmed | Targeting Lung Cancer Stem Cells: Research and Clinical Impacts |
| title_short | Targeting Lung Cancer Stem Cells: Research and Clinical Impacts |
| title_sort | targeting lung cancer stem cells: research and clinical impacts |
| topic | RK1-715 Dentistry |
| url | http://eprints.usm.my/37242/ http://eprints.usm.my/37242/ http://eprints.usm.my/37242/1/%28Targeting_Lung_Cancer_Stem%29_fonc-07-00080.pdf |