Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives
Chitosan is a natural macromolecular polysaccharide, derived from chitin extracted from the exoskeleton of some marine invertebrates. This study was designed to evaluate the expression of P-selectin, thromboxane A2 (TXA2), transforming growth factor-β1 (TGF- β1) and platelet derived growth factor...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Online Research Book Publication, India
2014
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| Subjects: | |
| Online Access: | http://eprints.usm.my/37226/ http://eprints.usm.my/37226/1/article3.pdf |
| _version_ | 1848878133849096192 |
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| author | Periayah, Mercy Halleluyah Halim , Ahmad Sukari Yaacob, Nik Soriani Mat Saad, Arman Zaharil Hussein, Abdul Rahim Abdul Rashid, Ahmad Hazri |
| author_facet | Periayah, Mercy Halleluyah Halim , Ahmad Sukari Yaacob, Nik Soriani Mat Saad, Arman Zaharil Hussein, Abdul Rahim Abdul Rashid, Ahmad Hazri |
| author_sort | Periayah, Mercy Halleluyah |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Chitosan is a natural macromolecular polysaccharide, derived from chitin extracted from
the exoskeleton of some marine invertebrates. This study was designed to evaluate the
expression of P-selectin, thromboxane A2 (TXA2), transforming growth factor-β1 (TGF-
β1) and platelet derived growth factor-AB (PDGF-AB) using enzyme-linked
immunosorbent assays (ELISAs). The chitosan derivatives utilized were 7% N,Ocarboxymethylchitosan
(NO-CMC) (with 0.45 mL collagen), 8% NO-CMC, oligo -
chitosan (O-C) and oligo -chitosan 53 (O-C 53). We found that O-C showed a
significantly superior effect compared to NO-CMC in achieving hemostasis. Post-hoc
multiple comparisons using Scheffe test indicated that p-values between the mean
differences of all the assayed chitosan derivatives were not significant. However, our
analyses successfully identified distinctions between the O-C and NO-CMC test groups
and blood alone. These results may expand the understanding of the ability of chitosan
derivatives to promote inflammatory responses and angiogenesis depending on their
physical and chemical structures |
| first_indexed | 2025-11-15T17:26:30Z |
| format | Article |
| id | usm-37226 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:26:30Z |
| publishDate | 2014 |
| publisher | Online Research Book Publication, India |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-372262017-10-23T08:43:46Z http://eprints.usm.my/37226/ Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives Periayah, Mercy Halleluyah Halim , Ahmad Sukari Yaacob, Nik Soriani Mat Saad, Arman Zaharil Hussein, Abdul Rahim Abdul Rashid, Ahmad Hazri RA0421 Public health. Hygiene. Preventive Medicine TP Chemical Technology Chitosan is a natural macromolecular polysaccharide, derived from chitin extracted from the exoskeleton of some marine invertebrates. This study was designed to evaluate the expression of P-selectin, thromboxane A2 (TXA2), transforming growth factor-β1 (TGF- β1) and platelet derived growth factor-AB (PDGF-AB) using enzyme-linked immunosorbent assays (ELISAs). The chitosan derivatives utilized were 7% N,Ocarboxymethylchitosan (NO-CMC) (with 0.45 mL collagen), 8% NO-CMC, oligo - chitosan (O-C) and oligo -chitosan 53 (O-C 53). We found that O-C showed a significantly superior effect compared to NO-CMC in achieving hemostasis. Post-hoc multiple comparisons using Scheffe test indicated that p-values between the mean differences of all the assayed chitosan derivatives were not significant. However, our analyses successfully identified distinctions between the O-C and NO-CMC test groups and blood alone. These results may expand the understanding of the ability of chitosan derivatives to promote inflammatory responses and angiogenesis depending on their physical and chemical structures Online Research Book Publication, India 2014-03 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/37226/1/article3.pdf Periayah, Mercy Halleluyah and Halim , Ahmad Sukari and Yaacob, Nik Soriani and Mat Saad, Arman Zaharil and Hussein, Abdul Rahim and Abdul Rashid, Ahmad Hazri (2014) Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives. Online International Interdisciplinary Research Journal, IV. pp. 5-14. ISSN 2249-9598 http://www.oiirj.org/oiirj/March2014-special-issue/02.pdf |
| spellingShingle | RA0421 Public health. Hygiene. Preventive Medicine TP Chemical Technology Periayah, Mercy Halleluyah Halim , Ahmad Sukari Yaacob, Nik Soriani Mat Saad, Arman Zaharil Hussein, Abdul Rahim Abdul Rashid, Ahmad Hazri Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives |
| title | Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives |
| title_full | Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives |
| title_fullStr | Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives |
| title_full_unstemmed | Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives |
| title_short | Expression of P-selectin, TXA2, TGF-β1 and PDGF-AB in the Presence of Bioadhesive Chitosan Derivatives |
| title_sort | expression of p-selectin, txa2, tgf-β1 and pdgf-ab in the presence of bioadhesive chitosan derivatives |
| topic | RA0421 Public health. Hygiene. Preventive Medicine TP Chemical Technology |
| url | http://eprints.usm.my/37226/ http://eprints.usm.my/37226/ http://eprints.usm.my/37226/1/article3.pdf |