Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model
Breast cancer has been recognized as the leading cause of death in women worldwide. Research has shown the importance of complementary and alternative therapies in cancer. In this study, we investigated the antitumoural therapeutic effects ofMalaysian Tualang honey (TH) and Australian/New Zealand...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2017
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| Online Access: | http://eprints.usm.my/37099/ http://eprints.usm.my/37099/1/%28Oral_Administration_of_Tualang%29_5904361.pdf |
| _version_ | 1848878096798711808 |
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| author | Ahmed, Sarfraz Sulaiman, Siti Amrah Othman, Nor Hayati |
| author_facet | Ahmed, Sarfraz Sulaiman, Siti Amrah Othman, Nor Hayati |
| author_sort | Ahmed, Sarfraz |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Breast cancer has been recognized as the leading cause of death in women worldwide. Research has shown the importance of
complementary and alternative therapies in cancer. In this study, we investigated the antitumoural therapeutic effects ofMalaysian
Tualang honey (TH) and Australian/New Zealand Manuka honey (MH) against breast cancer in rats. Thirty syngeneic virgin
female Sprague-Dawley (SD) rats were induced by the carcinogen 1-methyl-1-nitrosourea (MNU) 80mg/kg. The treatment started
when first palpable tumour reached 10–12mm in size by dividing rats into following groups: Group 0 (negative control); Group
1 (positive control); and Groups 2 and 3 which received 1.0 g/kg body weight/day of TH and MH, respectively, for 120 days.
The data demonstrate that cancer masses in TH and MH treated groups showed a lower median tumour size, weight, and
multiplicity compared with the nontreated positive control ( |
| first_indexed | 2025-11-15T17:25:55Z |
| format | Article |
| id | usm-37099 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:25:55Z |
| publishDate | 2017 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-370992017-10-13T02:31:16Z http://eprints.usm.my/37099/ Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model Ahmed, Sarfraz Sulaiman, Siti Amrah Othman, Nor Hayati RB Pathology RM Therapeutics. Pharmacology Breast cancer has been recognized as the leading cause of death in women worldwide. Research has shown the importance of complementary and alternative therapies in cancer. In this study, we investigated the antitumoural therapeutic effects ofMalaysian Tualang honey (TH) and Australian/New Zealand Manuka honey (MH) against breast cancer in rats. Thirty syngeneic virgin female Sprague-Dawley (SD) rats were induced by the carcinogen 1-methyl-1-nitrosourea (MNU) 80mg/kg. The treatment started when first palpable tumour reached 10–12mm in size by dividing rats into following groups: Group 0 (negative control); Group 1 (positive control); and Groups 2 and 3 which received 1.0 g/kg body weight/day of TH and MH, respectively, for 120 days. The data demonstrate that cancer masses in TH and MH treated groups showed a lower median tumour size, weight, and multiplicity compared with the nontreated positive control ( Hindawi Publishing Corporation 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/37099/1/%28Oral_Administration_of_Tualang%29_5904361.pdf Ahmed, Sarfraz and Sulaiman, Siti Amrah and Othman, Nor Hayati (2017) Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model. Evidence-Based Complementary and Alternative Medicine, 2017 (590436). pp. 1-15. ISSN 1741-427X https://doi.org/10.1155/2017/5904361 |
| spellingShingle | RB Pathology RM Therapeutics. Pharmacology Ahmed, Sarfraz Sulaiman, Siti Amrah Othman, Nor Hayati Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model |
| title | Oral Administration of Tualang and Manuka Honeys Modulates
Breast Cancer Progression in Sprague-Dawley Rats Model |
| title_full | Oral Administration of Tualang and Manuka Honeys Modulates
Breast Cancer Progression in Sprague-Dawley Rats Model |
| title_fullStr | Oral Administration of Tualang and Manuka Honeys Modulates
Breast Cancer Progression in Sprague-Dawley Rats Model |
| title_full_unstemmed | Oral Administration of Tualang and Manuka Honeys Modulates
Breast Cancer Progression in Sprague-Dawley Rats Model |
| title_short | Oral Administration of Tualang and Manuka Honeys Modulates
Breast Cancer Progression in Sprague-Dawley Rats Model |
| title_sort | oral administration of tualang and manuka honeys modulates
breast cancer progression in sprague-dawley rats model |
| topic | RB Pathology RM Therapeutics. Pharmacology |
| url | http://eprints.usm.my/37099/ http://eprints.usm.my/37099/ http://eprints.usm.my/37099/1/%28Oral_Administration_of_Tualang%29_5904361.pdf |