Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus
Since diabetes mellitus (DM) is one of the most common and serious endocrine metabolic disorders, it is important to elucidate novel antidiabetic therapeutic agents from various sources, including natural products. Bee venom (BV) is a complex mixture of proteins, peptides, and low molecular compon...
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2017
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| Online Access: | http://eprints.usm.my/37052/ http://eprints.usm.my/37052/1/%28Melittin%2C_a_Potential_Natural%29_4035626.pdf |
| _version_ | 1848878083817340928 |
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| author | Hossen, Md. Sakib Siew, Hua Gan Khalil, Md. Ibrahim |
| author_facet | Hossen, Md. Sakib Siew, Hua Gan Khalil, Md. Ibrahim |
| author_sort | Hossen, Md. Sakib |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Since diabetes mellitus (DM) is one of the most common and serious endocrine metabolic disorders, it is important to elucidate
novel antidiabetic therapeutic agents from various sources, including natural products. Bee venom (BV) is a complex mixture
of proteins, peptides, and low molecular components, and melittin is the main constituent. Melittin is a peptide consisting of
26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. It has several important biological effects and has a
relatively low toxicity. Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering
activities by acting on several mechanistic pathways. The main antidiabetic activity of melittin is increasing insulin secretion
via depolarization of pancreatic |
| first_indexed | 2025-11-15T17:25:42Z |
| format | Article |
| id | usm-37052 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:25:42Z |
| publishDate | 2017 |
| publisher | Hindawi Publishing Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-370522017-10-11T06:54:20Z http://eprints.usm.my/37052/ Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus Hossen, Md. Sakib Siew, Hua Gan Khalil, Md. Ibrahim R5-130.5 General works Since diabetes mellitus (DM) is one of the most common and serious endocrine metabolic disorders, it is important to elucidate novel antidiabetic therapeutic agents from various sources, including natural products. Bee venom (BV) is a complex mixture of proteins, peptides, and low molecular components, and melittin is the main constituent. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. It has several important biological effects and has a relatively low toxicity. Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering activities by acting on several mechanistic pathways. The main antidiabetic activity of melittin is increasing insulin secretion via depolarization of pancreatic Hindawi Publishing Corporation 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/37052/1/%28Melittin%2C_a_Potential_Natural%29_4035626.pdf Hossen, Md. Sakib and Siew, Hua Gan and Khalil, Md. Ibrahim (2017) Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus. Journal of Chemistry, 2017 (403562). pp. 1-7. ISSN 2090-9063 https://doi.org/10.1155/2017/4035626 |
| spellingShingle | R5-130.5 General works Hossen, Md. Sakib Siew, Hua Gan Khalil, Md. Ibrahim Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus |
| title | Melittin, a Potential Natural Toxin of Crude Bee Venom:
Probable Future Arsenal in the Treatment of Diabetes Mellitus |
| title_full | Melittin, a Potential Natural Toxin of Crude Bee Venom:
Probable Future Arsenal in the Treatment of Diabetes Mellitus |
| title_fullStr | Melittin, a Potential Natural Toxin of Crude Bee Venom:
Probable Future Arsenal in the Treatment of Diabetes Mellitus |
| title_full_unstemmed | Melittin, a Potential Natural Toxin of Crude Bee Venom:
Probable Future Arsenal in the Treatment of Diabetes Mellitus |
| title_short | Melittin, a Potential Natural Toxin of Crude Bee Venom:
Probable Future Arsenal in the Treatment of Diabetes Mellitus |
| title_sort | melittin, a potential natural toxin of crude bee venom:
probable future arsenal in the treatment of diabetes mellitus |
| topic | R5-130.5 General works |
| url | http://eprints.usm.my/37052/ http://eprints.usm.my/37052/ http://eprints.usm.my/37052/1/%28Melittin%2C_a_Potential_Natural%29_4035626.pdf |