Molecular characterization of peroxisome proliferator activated receptor gamma2 (PPARγ2) promoter from bovine
Peroxisome proliferator activated receptor gamma (PPARγ) is a member of the PPAR subfamily of nuclear hormone receptors (Schoonjans et al., 1996a). So far, two PPARγ isoforms; γ1 and γ2, have been cloned in bovine and produced by alternative promoter usage and differential splicing of a single gene...
| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2004
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| Subjects: | |
| Online Access: | http://eprints.usm.my/36873/ http://eprints.usm.my/36873/1/pBIO27.pdf |
| Summary: | Peroxisome proliferator activated receptor gamma (PPARγ) is a member of the PPAR subfamily of nuclear hormone receptors (Schoonjans et al., 1996a). So far, two PPARγ isoforms; γ1 and γ2, have been cloned in bovine and produced by alternative promoter usage and differential splicing of a single gene (Sundvold et al., 1997). PPARγ functions by forming heterodimeric complexes with 9-cis-retinoic acid X receptors (RXRs). This heterodimer regulates transcription by binding to PPRE, known also as DR-1 response element in the regulatory regions of target genes (Tontonoz et al., 1994a). |
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