Aptamer Technology: Adjunct Therapy for Malaria
Malaria is a life-threatening parasitic infection occurring in the endemic areas, primarily in children under the age of five, pregnant women, and patients with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV)/(AIDS) as well as non-immune individuals. The cytoadherence of...
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| Format: | Article |
| Language: | English |
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MDPI
2017
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| Online Access: | http://eprints.usm.my/36807/ http://eprints.usm.my/36807/1/%28Aptamer_Technology_Adjunct%29_biomedicines-05-00001.pdf |
| _version_ | 1848878016427458560 |
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| author | Kamarudin, Nik Abdul Aziz Nik Mohammed, Nurul Adila Mustaffa, Khairul Mohd Fadzli |
| author_facet | Kamarudin, Nik Abdul Aziz Nik Mohammed, Nurul Adila Mustaffa, Khairul Mohd Fadzli |
| author_sort | Kamarudin, Nik Abdul Aziz Nik |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Malaria is a life-threatening parasitic infection occurring in the endemic areas, primarily
in children under the age of five, pregnant women, and patients with human immunodeficiency
virus and acquired immunodeficiency syndrome (HIV)/(AIDS) as well as non-immune individuals.
The cytoadherence of infected erythrocytes (IEs) to the host endothelial surface receptor is a known
factor that contributes to the increased prevalence of severe malaria cases due to the accumulation of
IEs, mainly in the brain and other vital organs. Therefore, further study is needed to discover a new
potential anti-adhesive drug to treat severe malaria thus reducing its mortality rate. In this review,
we discuss how the aptamer technology could be applied in the development of a new adjunct
therapy for current malaria treatment. |
| first_indexed | 2025-11-15T17:24:38Z |
| format | Article |
| id | usm-36807 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:24:38Z |
| publishDate | 2017 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-368072020-05-04T00:57:48Z http://eprints.usm.my/36807/ Aptamer Technology: Adjunct Therapy for Malaria Kamarudin, Nik Abdul Aziz Nik Mohammed, Nurul Adila Mustaffa, Khairul Mohd Fadzli R735-854 Medical education. Medical schools. Research Malaria is a life-threatening parasitic infection occurring in the endemic areas, primarily in children under the age of five, pregnant women, and patients with human immunodeficiency virus and acquired immunodeficiency syndrome (HIV)/(AIDS) as well as non-immune individuals. The cytoadherence of infected erythrocytes (IEs) to the host endothelial surface receptor is a known factor that contributes to the increased prevalence of severe malaria cases due to the accumulation of IEs, mainly in the brain and other vital organs. Therefore, further study is needed to discover a new potential anti-adhesive drug to treat severe malaria thus reducing its mortality rate. In this review, we discuss how the aptamer technology could be applied in the development of a new adjunct therapy for current malaria treatment. MDPI 2017 Article PeerReviewed application/pdf en http://eprints.usm.my/36807/1/%28Aptamer_Technology_Adjunct%29_biomedicines-05-00001.pdf Kamarudin, Nik Abdul Aziz Nik and Mohammed, Nurul Adila and Mustaffa, Khairul Mohd Fadzli (2017) Aptamer Technology: Adjunct Therapy for Malaria. Biomedicines, 5 (1). pp. 1-14. ISSN 2227-9059 http://www.mdpi.com/journal/biomedicines |
| spellingShingle | R735-854 Medical education. Medical schools. Research Kamarudin, Nik Abdul Aziz Nik Mohammed, Nurul Adila Mustaffa, Khairul Mohd Fadzli Aptamer Technology: Adjunct Therapy for Malaria |
| title | Aptamer Technology: Adjunct Therapy for Malaria |
| title_full | Aptamer Technology: Adjunct Therapy for Malaria |
| title_fullStr | Aptamer Technology: Adjunct Therapy for Malaria |
| title_full_unstemmed | Aptamer Technology: Adjunct Therapy for Malaria |
| title_short | Aptamer Technology: Adjunct Therapy for Malaria |
| title_sort | aptamer technology: adjunct therapy for malaria |
| topic | R735-854 Medical education. Medical schools. Research |
| url | http://eprints.usm.my/36807/ http://eprints.usm.my/36807/ http://eprints.usm.my/36807/1/%28Aptamer_Technology_Adjunct%29_biomedicines-05-00001.pdf |