Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children
Masalah berat badan berlebihan dan obesiti telah menjadi isu yang membimbangkan di seluruh dunia dan masalah ini terus meningkat. Ketidakseimbangan penggunaan tenaga optima di mana pengambilan tenaga melebihi penggunaan tenaga menyebabkan obesiti. Masalah obesiti boleh disebabkan oleh interaksi...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2013
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/36422/ http://eprints.usm.my/36422/1/Dr._Tan_Yee_Lin_TSTZ_%28NN24%29.pdf |
| _version_ | 1848877905440931840 |
|---|---|
| author | Tan, Yee Lin |
| author_facet | Tan, Yee Lin |
| author_sort | Tan, Yee Lin |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Masalah berat badan berlebihan dan obesiti telah menjadi isu yang
membimbangkan di seluruh dunia dan masalah ini terus meningkat.
Ketidakseimbangan penggunaan tenaga optima di mana pengambilan
tenaga melebihi penggunaan tenaga menyebabkan obesiti. Masalah obesiti
boleh disebabkan oleh interaksi antara faktor genetik, tingkahlaku dan
persekitaran. Mutasi MC4R merupakan mutasi yang paling lazim dikenali
sebagai punca 'monogenic obesity' dalam manusia. Ia menjejaskan
homeostasis tenaga dengan meningkatkan pengambilan makanan dan
mengurangkan penggunaan tenaga. Adalah didapati bahawa mutasi
'melanocortin 4 receptor' (MC4R) N62S yang ditemui dalam kalangan kanak-kanak
yang berasal dari Pakistan telah menjejaskan sebahagian fungsi
reseptor dan hal tersebut mungkin menyebabkan obesiti.
Overweight and obesity has become an alarming issue worldwide and the
problem is on the rise. Obesity arises when there is energy imbalance where
energy intake exceeding energy expenditure. It can be resulted from the
interaction between genetic, behavioral and environmental factors.
Melanocortin 4 receptor (MC4R) mutation is the most common known
monogenic cause of human obesity that impairs energy homeostasis by
increasing food intake and decreasing energy expenditure. MC4R mutation
N62S which was found in children of Pakistani origin was found to partially
impair the receptor function which might cause obesity.
|
| first_indexed | 2025-11-15T17:22:52Z |
| format | Thesis |
| id | usm-36422 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:22:52Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-364222019-04-12T05:26:15Z http://eprints.usm.my/36422/ Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children Tan, Yee Lin RC1200 Sports Medicine Masalah berat badan berlebihan dan obesiti telah menjadi isu yang membimbangkan di seluruh dunia dan masalah ini terus meningkat. Ketidakseimbangan penggunaan tenaga optima di mana pengambilan tenaga melebihi penggunaan tenaga menyebabkan obesiti. Masalah obesiti boleh disebabkan oleh interaksi antara faktor genetik, tingkahlaku dan persekitaran. Mutasi MC4R merupakan mutasi yang paling lazim dikenali sebagai punca 'monogenic obesity' dalam manusia. Ia menjejaskan homeostasis tenaga dengan meningkatkan pengambilan makanan dan mengurangkan penggunaan tenaga. Adalah didapati bahawa mutasi 'melanocortin 4 receptor' (MC4R) N62S yang ditemui dalam kalangan kanak-kanak yang berasal dari Pakistan telah menjejaskan sebahagian fungsi reseptor dan hal tersebut mungkin menyebabkan obesiti. Overweight and obesity has become an alarming issue worldwide and the problem is on the rise. Obesity arises when there is energy imbalance where energy intake exceeding energy expenditure. It can be resulted from the interaction between genetic, behavioral and environmental factors. Melanocortin 4 receptor (MC4R) mutation is the most common known monogenic cause of human obesity that impairs energy homeostasis by increasing food intake and decreasing energy expenditure. MC4R mutation N62S which was found in children of Pakistani origin was found to partially impair the receptor function which might cause obesity. 2013-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/36422/1/Dr._Tan_Yee_Lin_TSTZ_%28NN24%29.pdf Tan, Yee Lin (2013) Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RC1200 Sports Medicine Tan, Yee Lin Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children |
| title | Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children |
| title_full | Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children |
| title_fullStr | Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children |
| title_full_unstemmed | Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children |
| title_short | Association of melanocortin 4 receptor (MC4R) gene mutation, physical activity, and food intake between normal and overweight Malay children |
| title_sort | association of melanocortin 4 receptor (mc4r) gene mutation, physical activity, and food intake between normal and overweight malay children |
| topic | RC1200 Sports Medicine |
| url | http://eprints.usm.my/36422/ http://eprints.usm.my/36422/1/Dr._Tan_Yee_Lin_TSTZ_%28NN24%29.pdf |