Identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm
Salmonella Typhi adalah patogen demam kepialu yang hanya menjangkiti manusia. Ia merupakan masalah kesihatan yang serius di negara-negara yang sedang membangun termasuk Malaysia. Walaupun langkah pencegahan dan rawatan perubatan telah dijalankan, tetapi wabak demam kepialu masih berlaku. Salah sa...
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| Format: | Thesis |
| Language: | English |
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2013
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| Online Access: | http://eprints.usm.my/36416/ http://eprints.usm.my/36416/1/Dr._Lee_Yen_Lurk_TSTZ_%28NN24%29.pdf |
| _version_ | 1848877903646818304 |
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| author | Lee, Yen Lurk |
| author_facet | Lee, Yen Lurk |
| author_sort | Lee, Yen Lurk |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Salmonella Typhi adalah patogen demam kepialu yang hanya menjangkiti manusia.
Ia merupakan masalah kesihatan yang serius di negara-negara yang sedang
membangun termasuk Malaysia. Walaupun langkah pencegahan dan rawatan
perubatan telah dijalankan, tetapi wabak demam kepialu masih berlaku. Salah satu
faktor yang menyumbang kepada keterusan deman kepialu adalah kewujudan
pembawa (carrier) deman kepialu yang tiada tanda-tanda klinikal. Wujudnya
pembawa deman kepialu adalah dijangka melibatkan biofilem yang terbentuk di
dalam pudi hempedu pesakit. Pembentukan biofilem membolehkan bakteria tersebut
mengelak serangan sistem imun mangsanya dan ubat antibiotik. Dalam usaha untuk
memahami pembentukan biofilem, satu kaedah untuk kultur S. Typhi biofilem in
vitro telah dicipta untuk memudahcarakan kajian ekpresi protein dan kekebalan
biofilem terhadap antibiotik.
Salmonella Typhi is a human specific pathogen which causes typhoid fever. It is a
major health problem in developing countries including Malaysia. Although
prevention and medical treatment are available, typhoid still persists. One of the
major factors contributing to typhoid persistence is the existence of asymptomatic
typhoid carriers. Biofilm formation in the human gallbladder is postulated to be
associated with development of carriers. Formation of biofilm enables the bacteria to
evade the host immune system and resist antibiotics. In order to understand the
formation of biofilm, a S. Typhi biofilm culture method was developed to facilitate
the biofilm protein expression and antibiotic resistance studies.
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| first_indexed | 2025-11-15T17:22:50Z |
| format | Thesis |
| id | usm-36416 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:22:50Z |
| publishDate | 2013 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-364162019-04-12T05:26:11Z http://eprints.usm.my/36416/ Identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm Lee, Yen Lurk R735-854 Medical education. Medical schools. Research Salmonella Typhi adalah patogen demam kepialu yang hanya menjangkiti manusia. Ia merupakan masalah kesihatan yang serius di negara-negara yang sedang membangun termasuk Malaysia. Walaupun langkah pencegahan dan rawatan perubatan telah dijalankan, tetapi wabak demam kepialu masih berlaku. Salah satu faktor yang menyumbang kepada keterusan deman kepialu adalah kewujudan pembawa (carrier) deman kepialu yang tiada tanda-tanda klinikal. Wujudnya pembawa deman kepialu adalah dijangka melibatkan biofilem yang terbentuk di dalam pudi hempedu pesakit. Pembentukan biofilem membolehkan bakteria tersebut mengelak serangan sistem imun mangsanya dan ubat antibiotik. Dalam usaha untuk memahami pembentukan biofilem, satu kaedah untuk kultur S. Typhi biofilem in vitro telah dicipta untuk memudahcarakan kajian ekpresi protein dan kekebalan biofilem terhadap antibiotik. Salmonella Typhi is a human specific pathogen which causes typhoid fever. It is a major health problem in developing countries including Malaysia. Although prevention and medical treatment are available, typhoid still persists. One of the major factors contributing to typhoid persistence is the existence of asymptomatic typhoid carriers. Biofilm formation in the human gallbladder is postulated to be associated with development of carriers. Formation of biofilm enables the bacteria to evade the host immune system and resist antibiotics. In order to understand the formation of biofilm, a S. Typhi biofilm culture method was developed to facilitate the biofilm protein expression and antibiotic resistance studies. 2013-07 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/36416/1/Dr._Lee_Yen_Lurk_TSTZ_%28NN24%29.pdf Lee, Yen Lurk (2013) Identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R735-854 Medical education. Medical schools. Research Lee, Yen Lurk Identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm |
| title | Identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm |
| title_full | Identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm |
| title_fullStr | Identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm |
| title_full_unstemmed | Identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm |
| title_short | Identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm |
| title_sort | identification of potential protein biomarkers from salmonella enterica subspecies enterica serovar typhi biofilm |
| topic | R735-854 Medical education. Medical schools. Research |
| url | http://eprints.usm.my/36416/ http://eprints.usm.my/36416/1/Dr._Lee_Yen_Lurk_TSTZ_%28NN24%29.pdf |