Evaluation Of Anti-Hypertensive And Vasorelaxant Effects Of Phaleria Macrocarpa Extracts
Kajian ini menyiasat kesan anti-hipertensi ekstrak Phaleria macrocarpa pada tikus hipertensi spontan (SHR), tikus Wistar Kyoto (WKY) dan kesan ekstrak terhadap vasorelaksasi di dalam cincin aortik terasing dari pada tikus Sprague Dawley menggunakan pendekatan bioaktiviti. Buah kering telah diekst...
| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | http://eprints.usm.my/31986/ http://eprints.usm.my/31986/1/Rabia_Altaf.pdf |
| _version_ | 1848876700523298816 |
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| author | Altaf, Rabia |
| author_facet | Altaf, Rabia |
| author_sort | Altaf, Rabia |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Kajian ini menyiasat kesan anti-hipertensi ekstrak Phaleria macrocarpa pada tikus
hipertensi spontan (SHR), tikus Wistar Kyoto (WKY) dan kesan ekstrak terhadap
vasorelaksasi di dalam cincin aortik terasing dari pada tikus Sprague Dawley
menggunakan pendekatan bioaktiviti. Buah kering telah diekstrak secara
berperingkat dengan pelarut-pelarut yang berkepolaran berbeza. Kesan antihipertensi
terhadap beberapa peringkat dos ekstrak telah dinilai dengan
menggunakan kaedah tekanan darah sistolik bukan invasif. Ekstrak eter petroleum
(PE) dan ekstrak air (WE) menurunkan tekanan darah pada hari ke-14 (15.9 dan
27.7% masing-masing, p<0.05), menunjukan kedua-dua ekstrak mempunyai kesan
aktiviti anti-hipertensi. WE menurunkan kedua-dua tekanan arteri purata (MAP)
dan kadar denyutan jantung (HR) pada tikus WKY sebanyak 16.3 dan 4.3%
masing-masing (p<0.05). WE menghalang peningkatan aruhan-norepinefrina (NE)
terhadap MAP dan HR dalam WKY dengan mengurangkan kesan isoprenalina
terhadap tindak balas presor (p<0.05), mencadangkan ada kemungkinan terdapatnya
kesan antagonis-alfa dan penghalang saluran kalsium.
The present study investigated the anti-hypertensive effect of Phaleria macrocarpa
extracts in spontaneously hypertensive rats (SHR), Wistar Kyoto (WKY) rats and
the vasorelaxant effect of the extracts in isolated rat aorta of Sprague Dawley rats
using bioactivity guided approach. The dried fruits were extracted sequentially in
solvents with different polarity. The anti-hypertensive effect of the graded doses of
crude extracts was evaluated in SHR by non-invasive blood pressure method.
Petroleum ether (PE) and water extracts (WE) significantly reduced the blood
pressure on 14th day of treatment (15.9 and 27.7% respectively, p<0.05) suggesting
profound anti-hypertensive activity of these two extracts. WE reduced both the
mean arterial pressure (MAP) and heart rate (HR) in WKY by 16.3 and 4.3%
respectively (p<0.05). |
| first_indexed | 2025-11-15T17:03:43Z |
| format | Thesis |
| id | usm-31986 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:03:43Z |
| publishDate | 2015 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-319862019-04-12T05:25:44Z http://eprints.usm.my/31986/ Evaluation Of Anti-Hypertensive And Vasorelaxant Effects Of Phaleria Macrocarpa Extracts Altaf, Rabia RS1-441 Pharmacy and materia medica Kajian ini menyiasat kesan anti-hipertensi ekstrak Phaleria macrocarpa pada tikus hipertensi spontan (SHR), tikus Wistar Kyoto (WKY) dan kesan ekstrak terhadap vasorelaksasi di dalam cincin aortik terasing dari pada tikus Sprague Dawley menggunakan pendekatan bioaktiviti. Buah kering telah diekstrak secara berperingkat dengan pelarut-pelarut yang berkepolaran berbeza. Kesan antihipertensi terhadap beberapa peringkat dos ekstrak telah dinilai dengan menggunakan kaedah tekanan darah sistolik bukan invasif. Ekstrak eter petroleum (PE) dan ekstrak air (WE) menurunkan tekanan darah pada hari ke-14 (15.9 dan 27.7% masing-masing, p<0.05), menunjukan kedua-dua ekstrak mempunyai kesan aktiviti anti-hipertensi. WE menurunkan kedua-dua tekanan arteri purata (MAP) dan kadar denyutan jantung (HR) pada tikus WKY sebanyak 16.3 dan 4.3% masing-masing (p<0.05). WE menghalang peningkatan aruhan-norepinefrina (NE) terhadap MAP dan HR dalam WKY dengan mengurangkan kesan isoprenalina terhadap tindak balas presor (p<0.05), mencadangkan ada kemungkinan terdapatnya kesan antagonis-alfa dan penghalang saluran kalsium. The present study investigated the anti-hypertensive effect of Phaleria macrocarpa extracts in spontaneously hypertensive rats (SHR), Wistar Kyoto (WKY) rats and the vasorelaxant effect of the extracts in isolated rat aorta of Sprague Dawley rats using bioactivity guided approach. The dried fruits were extracted sequentially in solvents with different polarity. The anti-hypertensive effect of the graded doses of crude extracts was evaluated in SHR by non-invasive blood pressure method. Petroleum ether (PE) and water extracts (WE) significantly reduced the blood pressure on 14th day of treatment (15.9 and 27.7% respectively, p<0.05) suggesting profound anti-hypertensive activity of these two extracts. WE reduced both the mean arterial pressure (MAP) and heart rate (HR) in WKY by 16.3 and 4.3% respectively (p<0.05). 2015-04 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/31986/1/Rabia_Altaf.pdf Altaf, Rabia (2015) Evaluation Of Anti-Hypertensive And Vasorelaxant Effects Of Phaleria Macrocarpa Extracts. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Altaf, Rabia Evaluation Of Anti-Hypertensive And Vasorelaxant Effects Of Phaleria Macrocarpa Extracts |
| title | Evaluation Of Anti-Hypertensive And Vasorelaxant
Effects Of Phaleria Macrocarpa Extracts
|
| title_full | Evaluation Of Anti-Hypertensive And Vasorelaxant
Effects Of Phaleria Macrocarpa Extracts
|
| title_fullStr | Evaluation Of Anti-Hypertensive And Vasorelaxant
Effects Of Phaleria Macrocarpa Extracts
|
| title_full_unstemmed | Evaluation Of Anti-Hypertensive And Vasorelaxant
Effects Of Phaleria Macrocarpa Extracts
|
| title_short | Evaluation Of Anti-Hypertensive And Vasorelaxant
Effects Of Phaleria Macrocarpa Extracts
|
| title_sort | evaluation of anti-hypertensive and vasorelaxant
effects of phaleria macrocarpa extracts |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/31986/ http://eprints.usm.my/31986/1/Rabia_Altaf.pdf |