Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity

Virus influenza telah dikenal pasti sebagai salah satu jangkitan paling lazim yang menyerang sistem pernafasan manusia. Virus ini boleh menyebabkan penyakit serius yang boleh membawa kepada peningkatan kadar penyakit dan kematian. Neuraminidase (NA) yang turut dikenali sebagai sialidase ialah protei...

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Main Author:	Zalaludin, Ayunni Salihah
Format:	Thesis
Language:	English
Published:	2015
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/31624/ http://eprints.usm.my/31624/1/Ayubbi_Salihah_Bt_Zalaludin.pdf

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author	Zalaludin, Ayunni Salihah
author_facet	Zalaludin, Ayunni Salihah
author_sort	Zalaludin, Ayunni Salihah
building	USM Institutional Repository
collection	Online Access
description	Virus influenza telah dikenal pasti sebagai salah satu jangkitan paling lazim yang menyerang sistem pernafasan manusia. Virus ini boleh menyebabkan penyakit serius yang boleh membawa kepada peningkatan kadar penyakit dan kematian. Neuraminidase (NA) yang turut dikenali sebagai sialidase ialah protein tetramer yang memainkan peranan penting dalam kehidupan virus influenza. Ini termasuk membantu pembebasan virus ke sel-sel yang berhampiran. Oleh itu, NA telah dikenal pasti sebagai sasaran untuk membangunkan strategi terapi bagi melawan jangkitan virus. Kajian ini menumpukan kepada pengekstrakan, fraksinasi dan pengasingan sebatian kimia alkaloid yang berpotensi sebagai aktiviti anti-neuraminidase dari Tabernaemontana divaricata yang telah dikenal pasti melalui penyaringan maya dari pangkalan data NADI diikuti dengan penilaian-penilaian in vitro dan in silico ke atas sebatian yang telah diasingkan bersama-sama dengan drug standard (DANA). Influenza virus was identified as one of the most common pathogens that infect human respiratory system. The infection may cause serious illness which could lead to high morbidity and mortality rate. Neuraminidase (NA), also known as sialidase is a tetramer protein which plays important roles in the life of influenza virus. This includes facilitating the release of the virus to other neighbouring cells. Thus NA has been identified as the target to develop therapeutic strategies against the viral infection. This study is focused on the extraction, fractionation and isolation of alkaloid chemical constituent with potential anti-neuraminidase activity from Tabernaemontana divaricata, identified by virtual screening from NADI database followed by in vitro and in silico evaluations of the isolated compound along with standard drug (DANA).
first_indexed	2025-11-15T17:02:28Z
format	Thesis
id	usm-31624
institution	Universiti Sains Malaysia
institution_category	Local University
language	English
last_indexed	2025-11-15T17:02:28Z
publishDate	2015
recordtype	eprints
repository_type	Digital Repository
spelling	usm-316242019-04-12T05:25:38Z http://eprints.usm.my/31624/ Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity Zalaludin, Ayunni Salihah RS1-441 Pharmacy and materia medica Virus influenza telah dikenal pasti sebagai salah satu jangkitan paling lazim yang menyerang sistem pernafasan manusia. Virus ini boleh menyebabkan penyakit serius yang boleh membawa kepada peningkatan kadar penyakit dan kematian. Neuraminidase (NA) yang turut dikenali sebagai sialidase ialah protein tetramer yang memainkan peranan penting dalam kehidupan virus influenza. Ini termasuk membantu pembebasan virus ke sel-sel yang berhampiran. Oleh itu, NA telah dikenal pasti sebagai sasaran untuk membangunkan strategi terapi bagi melawan jangkitan virus. Kajian ini menumpukan kepada pengekstrakan, fraksinasi dan pengasingan sebatian kimia alkaloid yang berpotensi sebagai aktiviti anti-neuraminidase dari Tabernaemontana divaricata yang telah dikenal pasti melalui penyaringan maya dari pangkalan data NADI diikuti dengan penilaian-penilaian in vitro dan in silico ke atas sebatian yang telah diasingkan bersama-sama dengan drug standard (DANA). Influenza virus was identified as one of the most common pathogens that infect human respiratory system. The infection may cause serious illness which could lead to high morbidity and mortality rate. Neuraminidase (NA), also known as sialidase is a tetramer protein which plays important roles in the life of influenza virus. This includes facilitating the release of the virus to other neighbouring cells. Thus NA has been identified as the target to develop therapeutic strategies against the viral infection. This study is focused on the extraction, fractionation and isolation of alkaloid chemical constituent with potential anti-neuraminidase activity from Tabernaemontana divaricata, identified by virtual screening from NADI database followed by in vitro and in silico evaluations of the isolated compound along with standard drug (DANA). 2015-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/31624/1/Ayubbi_Salihah_Bt_Zalaludin.pdf Zalaludin, Ayunni Salihah (2015) Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity. Masters thesis, Universiti Sains Malaysia.
spellingShingle	RS1-441 Pharmacy and materia medica Zalaludin, Ayunni Salihah Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity
title	Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity
title_full	Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity
title_fullStr	Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity
title_full_unstemmed	Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity
title_short	Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity
title_sort	extraction and isolation of chemical compound from tabernaemontana divaricata (l.) r.br. ex roem. & schult. leaves with potential anti-neuraminidase activity
topic	RS1-441 Pharmacy and materia medica
url	http://eprints.usm.my/31624/ http://eprints.usm.my/31624/1/Ayubbi_Salihah_Bt_Zalaludin.pdf

Extraction And Isolation Of Chemical Compound From Tabernaemontana Divaricata (L.) R.Br. Ex Roem. & Schult. Leaves With Potential Anti-Neuraminidase Activity

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