Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats
Introduction. Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological properties. Objective. To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC aqueous extract in normal and diabetic rats....
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| Format: | Article |
| Language: | English |
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Hindawi
2015
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| Online Access: | http://eprints.usm.my/31564/ http://eprints.usm.my/31564/1/SzeHan_PSC_Antidiabetic_BioMed_RI__Nov_2015_214918.pdf |
| _version_ | 1848876605564256256 |
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| author | Sze, Han Ng Mohd Zain, Mohd Syazwan Wan Rosli, W. I. |
| author_facet | Sze, Han Ng Mohd Zain, Mohd Syazwan Wan Rosli, W. I. |
| author_sort | Sze, Han Ng |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Introduction. Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological
properties. Objective. To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC
aqueous extract in normal and diabetic rats. Materials and Methods. A single dose of 500, 750, or 1000mg/kg of the PSC extract
was given to experimental rats to determine the effects on blood glucose (BG) and oral glucose tolerance test (OGTT). The effective
dose (750mg/kg) of PSC extract was repeatedly administrated daily for 21 days in diabetic rats to examine its antidiabetic effects in
terms of BG control, body weight, urine sugar, HbA1c, and several serum profiles. Results.The dose of 750 mg/kg showed the most
significant BG reduction (23.5%) in normal rats 6 hours after administration in BG study ( |
| first_indexed | 2025-11-15T17:02:12Z |
| format | Article |
| id | usm-31564 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:02:12Z |
| publishDate | 2015 |
| publisher | Hindawi |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-315642017-08-28T05:02:45Z http://eprints.usm.my/31564/ Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats Sze, Han Ng Mohd Zain, Mohd Syazwan Wan Rosli, W. I. RA0421 Public health. Hygiene. Preventive Medicine TX341-641 Nutrition. Foods and food supply Introduction. Pleurotus sajor-caju (PSC) is an edible oyster mushroom featuring high nutritional values and pharmacological properties. Objective. To investigate the hypoglycemic and antidiabetic effects of single and repeated oral administration of PSC aqueous extract in normal and diabetic rats. Materials and Methods. A single dose of 500, 750, or 1000mg/kg of the PSC extract was given to experimental rats to determine the effects on blood glucose (BG) and oral glucose tolerance test (OGTT). The effective dose (750mg/kg) of PSC extract was repeatedly administrated daily for 21 days in diabetic rats to examine its antidiabetic effects in terms of BG control, body weight, urine sugar, HbA1c, and several serum profiles. Results.The dose of 750 mg/kg showed the most significant BG reduction (23.5%) in normal rats 6 hours after administration in BG study ( Hindawi 2015 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/31564/1/SzeHan_PSC_Antidiabetic_BioMed_RI__Nov_2015_214918.pdf Sze, Han Ng and Mohd Zain, Mohd Syazwan and Wan Rosli, W. I. (2015) Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats. BioMed Research International, 2015. p. 8. ISSN 2314-6141 https://www.hindawi.com/journals/bmri |
| spellingShingle | RA0421 Public health. Hygiene. Preventive Medicine TX341-641 Nutrition. Foods and food supply Sze, Han Ng Mohd Zain, Mohd Syazwan Wan Rosli, W. I. Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats |
| title | Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats |
| title_full | Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats |
| title_fullStr | Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats |
| title_full_unstemmed | Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats |
| title_short | Hypoglycemic and Antidiabetic Effect of Pleurotus sajor-caju Aqueous Extract in Normal and Streptozotocin-Induced Diabetic Rats |
| title_sort | hypoglycemic and antidiabetic effect of pleurotus sajor-caju aqueous extract in normal and streptozotocin-induced diabetic rats |
| topic | RA0421 Public health. Hygiene. Preventive Medicine TX341-641 Nutrition. Foods and food supply |
| url | http://eprints.usm.my/31564/ http://eprints.usm.my/31564/ http://eprints.usm.my/31564/1/SzeHan_PSC_Antidiabetic_BioMed_RI__Nov_2015_214918.pdf |