Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats
Benincasa hispida, Bh (winter melon) is a good source of natural sugars, amino acids, organic acids, mineral elements and vitamins. This study was designed to explore the glycaemic effect of Bh aqueous extract in diabetic rats. Male Sprague-Dawley rats (250-350g) were induced to become diabetic with...
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| Format: | Article |
| Language: | English |
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School of Health Sciences, Universiti Sains Malaysia,
2016
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| Online Access: | http://eprints.usm.my/31523/ http://eprints.usm.my/31523/1/BH_Fatariah_Jun_2016.pdf |
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| author | Zakaria, Fatariah Wan Rosli, W. I. Ng, Sze Han Zain , Mohd Shazwan Wan Ahmad, Wan Amir Nizam |
| author_facet | Zakaria, Fatariah Wan Rosli, W. I. Ng, Sze Han Zain , Mohd Shazwan Wan Ahmad, Wan Amir Nizam |
| author_sort | Zakaria, Fatariah |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Benincasa hispida, Bh (winter melon) is a good source of natural sugars, amino acids, organic acids, mineral elements and vitamins. This study was designed to explore the glycaemic effect of Bh aqueous extract in diabetic rats. Male Sprague-Dawley rats (250-350g) were induced to become diabetic with streptozotocin (STZ, 45mg/kg intraperitoneal). The Bh aqueous extracts of 100, 250 and 500 mg/kg and metformin were administered through oral gavage to determine their effects on fasting blood glucose (FBG) and oral glucose tolerance test. The dose of 250 mg/kg was found to be the most effective dose and it decreased blood glucose level (BGL) by 11.8% in normal healthy rats after 6H of administration. The same dose also caused a marked reduction in BGL of 33.1% in normal rats, 38.7% in severe diabetic rats and 64.7% in mildly diabetic rats in OGTT after 3H of oral administration of the extract. The changes of BGL were not significant compared to normal rats. It shows that the extract is diabetic-friendly since the blood glucose levels were stable throughout the study period. These trends of BGL reduction show that Bh aqueous extract is diabetic friendly. |
| first_indexed | 2025-11-15T17:02:01Z |
| format | Article |
| id | usm-31523 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:02:01Z |
| publishDate | 2016 |
| publisher | School of Health Sciences, Universiti Sains Malaysia, |
| recordtype | eprints |
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| spelling | usm-315232017-08-28T05:02:44Z http://eprints.usm.my/31523/ Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats Zakaria, Fatariah Wan Rosli, W. I. Ng, Sze Han Zain , Mohd Shazwan Wan Ahmad, Wan Amir Nizam RA0421 Public health. Hygiene. Preventive Medicine TX341-641 Nutrition. Foods and food supply Benincasa hispida, Bh (winter melon) is a good source of natural sugars, amino acids, organic acids, mineral elements and vitamins. This study was designed to explore the glycaemic effect of Bh aqueous extract in diabetic rats. Male Sprague-Dawley rats (250-350g) were induced to become diabetic with streptozotocin (STZ, 45mg/kg intraperitoneal). The Bh aqueous extracts of 100, 250 and 500 mg/kg and metformin were administered through oral gavage to determine their effects on fasting blood glucose (FBG) and oral glucose tolerance test. The dose of 250 mg/kg was found to be the most effective dose and it decreased blood glucose level (BGL) by 11.8% in normal healthy rats after 6H of administration. The same dose also caused a marked reduction in BGL of 33.1% in normal rats, 38.7% in severe diabetic rats and 64.7% in mildly diabetic rats in OGTT after 3H of oral administration of the extract. The changes of BGL were not significant compared to normal rats. It shows that the extract is diabetic-friendly since the blood glucose levels were stable throughout the study period. These trends of BGL reduction show that Bh aqueous extract is diabetic friendly. School of Health Sciences, Universiti Sains Malaysia, 2016 Article PeerReviewed application/pdf en cc_by_nc_sa http://eprints.usm.my/31523/1/BH_Fatariah_Jun_2016.pdf Zakaria, Fatariah and Wan Rosli, W. I. and Ng, Sze Han and Zain , Mohd Shazwan and Wan Ahmad, Wan Amir Nizam (2016) Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats. Health and the Environment Journal, 7 (1). pp. 1-12. ISSN 2180-1126 http://www.hej.kk.usm.my |
| spellingShingle | RA0421 Public health. Hygiene. Preventive Medicine TX341-641 Nutrition. Foods and food supply Zakaria, Fatariah Wan Rosli, W. I. Ng, Sze Han Zain , Mohd Shazwan Wan Ahmad, Wan Amir Nizam Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats |
| title | Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats |
| title_full | Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats |
| title_fullStr | Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats |
| title_full_unstemmed | Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats |
| title_short | Assessment of Glycaemic Effect of Benincasa hispida Aqueous Extract in Streptozotocin Diabetic Rats |
| title_sort | assessment of glycaemic effect of benincasa hispida aqueous extract in streptozotocin diabetic rats |
| topic | RA0421 Public health. Hygiene. Preventive Medicine TX341-641 Nutrition. Foods and food supply |
| url | http://eprints.usm.my/31523/ http://eprints.usm.my/31523/ http://eprints.usm.my/31523/1/BH_Fatariah_Jun_2016.pdf |