Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones
Kajian ini dimulakan dengan sintesis dan pencirian dua siri utama bahan pemula: pengalkilan naftaldehid (2-8) dan pengasetilan kumarin tertukar ganti (9-11). Bahan pemula yang diperoleh dikenalpasti melalui kaedah spektroskopi seperti inframerah transformasi Fourier (FTIR), resonans magnet nukleus (...
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| Format: | Thesis |
| Language: | English |
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2016
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| Online Access: | http://eprints.usm.my/31375/ http://eprints.usm.my/31375/1/SUMITHDA_LIM_YEONG_HUI_24.pdf |
| _version_ | 1848876554067640320 |
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| author | Lim , Sumithda Yeong Hui |
| author_facet | Lim , Sumithda Yeong Hui |
| author_sort | Lim , Sumithda Yeong Hui |
| building | USM Institutional Repository |
| collection | Online Access |
| description | Kajian ini dimulakan dengan sintesis dan pencirian dua siri utama bahan pemula: pengalkilan naftaldehid (2-8) dan pengasetilan kumarin tertukar ganti (9-11). Bahan pemula yang diperoleh dikenalpasti melalui kaedah spektroskopi seperti inframerah transformasi Fourier (FTIR), resonans magnet nukleus (NMR) dan mikroanalisis CHN. Analisa pembelauan sinar-X hablur tunggal (XRD) juga dijalankan dengan hablur bagi sebatian 3, 34, dan 41 menghablur dalam sistem kristal triklinik. Lima siri kalkon kemudiannya disintesis melalui kaedah kondensasi Claisen-Schmidt dengan tiga siri diterbitkan daripada kumarin asetil tertukar ganti (12-33) dan dua siri yang lain diterbitkan daripada asetofenon tertukar ganti (34-46). Semua kalkon yang disintesis telah dicirikan dengan analisa unsur (CHN), spektroskopi FTIR , 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC dan 1H-13C HMBC. Kalkon 23, 28, 34, dan 41 telah dipilih untuk analisis kristolografi.
This study was started by the synthesis and characterization of two main series of starting materials: alkylation of naphthaldehydes (2-8) and acetylation of substituted coumarins (9-11). The starting materials thus obtained were elucidated by the spectroscopic methods such as fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and CHN microanalyses. Single crystal X-ray diffraction (XRD) analyses have also been carried out wherein the crystals of compound 3, 34 and 41 crystallized in a triclinic crystal system. Five novel series of chalcones were subsequently synthesized by means of Claisen-Schmidt condensation wherein three series were derived from substituted acetyl coumarins (12-33) and the remaining two series was derived from substituted acetophenones (34-46). All the synthesized chalcones were characterized by elemental analysis (CHN), FTIR, 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC and 1H-13C HMBC spectroscopy. Selected chalcones, 23, 28, 34, and 41 were selected for crystallography analysis. |
| first_indexed | 2025-11-15T17:01:23Z |
| format | Thesis |
| id | usm-31375 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T17:01:23Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-313752019-04-12T05:25:23Z http://eprints.usm.my/31375/ Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones Lim , Sumithda Yeong Hui QC1 Physics (General) Kajian ini dimulakan dengan sintesis dan pencirian dua siri utama bahan pemula: pengalkilan naftaldehid (2-8) dan pengasetilan kumarin tertukar ganti (9-11). Bahan pemula yang diperoleh dikenalpasti melalui kaedah spektroskopi seperti inframerah transformasi Fourier (FTIR), resonans magnet nukleus (NMR) dan mikroanalisis CHN. Analisa pembelauan sinar-X hablur tunggal (XRD) juga dijalankan dengan hablur bagi sebatian 3, 34, dan 41 menghablur dalam sistem kristal triklinik. Lima siri kalkon kemudiannya disintesis melalui kaedah kondensasi Claisen-Schmidt dengan tiga siri diterbitkan daripada kumarin asetil tertukar ganti (12-33) dan dua siri yang lain diterbitkan daripada asetofenon tertukar ganti (34-46). Semua kalkon yang disintesis telah dicirikan dengan analisa unsur (CHN), spektroskopi FTIR , 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC dan 1H-13C HMBC. Kalkon 23, 28, 34, dan 41 telah dipilih untuk analisis kristolografi. This study was started by the synthesis and characterization of two main series of starting materials: alkylation of naphthaldehydes (2-8) and acetylation of substituted coumarins (9-11). The starting materials thus obtained were elucidated by the spectroscopic methods such as fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) and CHN microanalyses. Single crystal X-ray diffraction (XRD) analyses have also been carried out wherein the crystals of compound 3, 34 and 41 crystallized in a triclinic crystal system. Five novel series of chalcones were subsequently synthesized by means of Claisen-Schmidt condensation wherein three series were derived from substituted acetyl coumarins (12-33) and the remaining two series was derived from substituted acetophenones (34-46). All the synthesized chalcones were characterized by elemental analysis (CHN), FTIR, 1H-NMR, 13C-NMR, DEPT 135, 1H-1H COSY, 1H-13C HMQC and 1H-13C HMBC spectroscopy. Selected chalcones, 23, 28, 34, and 41 were selected for crystallography analysis. 2016-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/31375/1/SUMITHDA_LIM_YEONG_HUI_24.pdf Lim , Sumithda Yeong Hui (2016) Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | QC1 Physics (General) Lim , Sumithda Yeong Hui Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones |
| title | Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones |
| title_full | Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones |
| title_fullStr | Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones |
| title_full_unstemmed | Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones |
| title_short | Synthesis, Characterization And Biological Evaluation Of Naphthalene - And Coumarin-Based Chalcones |
| title_sort | synthesis, characterization and biological evaluation of naphthalene - and coumarin-based chalcones |
| topic | QC1 Physics (General) |
| url | http://eprints.usm.my/31375/ http://eprints.usm.my/31375/1/SUMITHDA_LIM_YEONG_HUI_24.pdf |